To the Editor: Association of ZNF804A polymorphisms with schizophrenia and antipsychotic drug efficacy in a Chinese Han population

Schizophrenia (SZ) is a debilitating mental disorder afflicting approximately 1% of the world's population. Family, twin, and adoption studies have indicated a significant genetic contribution to the etiology of this disease, with many genes exerting weakto-moderate effects on predisposition. Indeed, association studies of single nucleotide polymorphisms (SNPs) have identified a number of promising susceptibility genes. A recent genome-wide association study reported a strong association between SNP rs1344706 in the zinc finger protein ZNF804A gene (2q32.1) and schizophrenia in the United Kingdom (O'Donovan et al., 2008). This association was subsequently replicated in the Irish population (Riley et al., 2010), suggesting that the rs1344706 variant of ZNF804A is a susceptibility gene for schizophrenia. We performed a case-control study to examine whether ZNF804A variants are associated with schizophrenia in the Chinese Han population. The patient group comprised 498 schizophrenia patients