Biological organisms as volatile compound detectors: a review.

The detection and identification of volatile compounds is essential to the successful undertaking of numerous forensic analyses. Biological olfactory systems possess the extraordinary ability to not only detect many thousands of distinct volatile compounds (odors) but also to discriminate between them. Whole-organism biological sensors, such as detection canines, have been employed in forensic science as volatile compound detectors for many years. A variety of insects including bees, wasps, and moths, which have also been shown to detect volatile compounds of forensic significance, have been investigated for their potential application in field-based detection systems. While the fundamental aim for many developers of portable instruments is to replicate the remarkable ability of biological olfactory systems, such analytical equipment is yet to possess the detection and discriminatory powers achieved by biological sensors. Recent literature reveals an increasing interest in olfactory receptors - the biological components that impart olfactory ability - for detecting volatile compounds associated with forensically significant substances such as explosives and illicit drugs. This paper reviews the literature regarding the current, and potential future, use of biological organisms as sensors for forensic science applications.

[1]  Julie B. Schweitzer,et al.  Handler beliefs affect scent detection dog outcomes , 2011, Animal Cognition.

[2]  C. R. Midkiff,et al.  UNCONFIRMED CANINE ACCELERANT DETECTION : A RELIABILITY ISSUE IN COURT , 1998 .

[4]  W. J. Lewis,et al.  Behavioral Monitoring of Trained Insects for Chemical Detection , 2006, Biotechnology progress.

[5]  U. Koch,et al.  Detection of volatiles released by diseased potato tubers using a biosensor on the basis of intact insect antennae , 1999 .

[6]  W. J. Lewis,et al.  The role of kairomones and other behavioral chemicals in host finding by parasitic insects. , 1976, Behavioral biology.

[7]  Coral G. Warr,et al.  Detection of Volatile Indicators of Illicit Substances by the Olfactory Receptors of Drosophila melanogaster , 2010, Chemical senses.

[8]  W. J. Lewis,et al.  Parasitic wasps learn and report diverse chemicals with unique conditionable behaviors. , 2003, Chemical senses.

[9]  Susan Fae Ann Bender,et al.  Tracking Honey Bees Using LIDAR (Light Detection and Ranging) Technology , 2003 .

[10]  Allison M. Curran,et al.  Characterization of the volatile organic compounds present in the headspace of decomposing human remains. , 2009, Forensic science international.

[11]  Glen C. Rains,et al.  LIMITS OF VOLATILE CHEMICAL DETECTION OF A PARASITOID WASP, Microplitis croceipes, AND AN ELECTRONIC NOSE: A COMPARATIVE STUDY , 2004 .

[12]  K Püschel,et al.  Cadaver dogs--a study on detection of contaminated carpet squares. , 2008, Forensic science international.

[13]  Cori Bargmann,et al.  Olfactory recognition and discrimination in Caenorhabditis elegans. , 1996, Cold Spring Harbor symposia on quantitative biology.

[14]  Yongsheng Li,et al.  Antennal olfactory responsiveness ofMicroplitis croceipes (Hymenoptera: Braconidae) to cotton plant volatiles , 1992, Journal of Chemical Ecology.

[15]  D. R. Reynolds,et al.  Tracking bees with harmonic radar , 1996, Nature.

[16]  J. Shaw,et al.  Can Honey Bees Assist in Area Reduction and Landmine Detection , 2003 .

[17]  K. Daly,et al.  The generalization of an olfactory-based conditioned response reveals unique but overlapping odour representations in the moth Manduca sexta. , 2001, The Journal of experimental biology.

[18]  Manuela M. Veloso,et al.  Automatically tracking and analyzing the behavior of live insect colonies , 2001, AGENTS '01.

[19]  R. Benton.  On the ORigin of smell: odorant receptors in insects , 2006, Cellular and Molecular Life Sciences CMLS.

[20]  W. J. Lewis,et al.  Host detection by chemically mediated associative learning in a parasitic wasp , 1988, Nature.

[21]  Isao Shimoyama,et al.  A Pheromone-Guided Mobile Robot that Behaves like a Silkworm Moth with Living Antennae as Pheromone Sensors , 1998, Int. J. Robotics Res..

[22]  Maki K Habib,et al.  Controlled biological and biomimetic systems for landmine detection. , 2007, Biosensors & bioelectronics.

[23]  Alan Poling,et al.  Using Giant African Pouched Rats (Cricetomys Gambianus) to Detect Landmines , 2010 .

[24]  Peggy L. Schmidt.  Companion animals as sentinels for public health. , 2009, The Veterinary clinics of North America. Small animal practice.

[25]  John R. Carlson,et al.  The Molecular Basis of Odor Coding in the Drosophila Larva , 2005, Neuron.

[26]  G A Schoon.  A first assessment of the reliability of an improved scent identification line-up. , 1998, Journal of forensic sciences.

[27]  Nathan Seldomridge,et al.  Polarization lidar measurements of honey bees in flight for locating land mines. , 2005, Optics express.

[28]  W. J. Lewis,et al.  Influence of handling and conditioning protocol on learning and memory of Microplitis croceipes , 2004 .

[29]  J. R. Lockwood,et al.  Alternatives for landmine detection , 2003 .

[30]  L. Vosshall,et al.  Sensing odorants and pheromones with chemosensory receptors. , 2009, Annual review of physiology.

[31]  Jian Wang,et al.  Greatly enhanced detection of a volatile ligand at femtomolar levels using bioluminescence resonance energy transfer (BRET). , 2011, Biosensors & bioelectronics.

[32]  M. Bitterman,et al.  Classical conditioning of proboscis extension in honeybees (Apis mellifera). , 1983, Journal of comparative psychology.

[33]  R. Glatz,et al.  Mimicking nature's noses: From receptor deorphaning to olfactory biosensing , 2011, Progress in Neurobiology.

[34]  D. Vu.  SPME/GC-MS characterization of volatiles associated with methamphetamine: toward the development of a pseudomethamphetamine training material. , 2001, Journal of forensic sciences.

[35]  L. Buck,et al.  Combinatorial Receptor Codes for Odors , 1999, Cell.

[36]  M. Billard,et al.  Evaluation of canines for accelerant detection at fire scenes. , 1994, Journal of forensic sciences.

[37]  E. H. Ashton,et al.  Studies in olfactory acuity. 4. Relative detectability of n-aliphatic acids by the dog , 1960 .

[38]  W. J. Lewis,et al.  Conditioned Microplitis croceipes Cresson (Hymenoptera: Braconidae) detect and respond to 2,4-DNT: development of a biological sensor. , 2005, Journal of Forensic Sciences.

[39]  U. Kaupp.  Olfactory signalling in vertebrates and insects: differences and commonalities , 2010, Nature Reviews Neuroscience.

[40]  Reta Tindall,et al.  An Evaluation of 42 Accelerant Detection Canine Teams , 1995 .

[41]  G.A.A. Schoon,et al.  Scent identification lineups by dogs (Canis familiaris): experimental design and forensic application , 1996 .

[42]  Jose R. Almirall,et al.  Analysis and interpretation of fire scene evidence , 2004 .

[43]  Hugh M Robertson,et al.  G Protein-Coupled Receptors in Anopheles gambiae , 2002, Science.

[44]  G. Rains,et al.  Development of Microplitis croceipes as a biological sensor , 2008 .

[45]  W. Lewis,et al.  Exploitation of Herbivore-Induced Plant Odors by Host-Seeking Parasitic Wasps , 1990, Science.

[46]  P. Mombaerts.  Seven-transmembrane proteins as odorant and chemosensory receptors. , 1999, Science.

[47]  Yizhar Lavner,et al.  A simple system for the remote detection and analysis of sniffing in explosives detection dogs , 2003, Behavior research methods, instruments, & computers : a journal of the Psychonomic Society, Inc.

[48]  W. J. Lewis,et al.  Use of learned odours by a parasitic wasp in accordance with host and food needs , 1990, Nature.

[49]  Hugh M Robertson,et al.  The chemoreceptor superfamily in the honey bee, Apis mellifera: expansion of the odorant, but not gustatory, receptor family. , 2006, Genome research.

[50]  J. Yinon,et al.  Modern Methods and Applications in Analysis of Explosives , 1996 .

[51]  James M. Johnston,et al.  Training and maintaining the performance of dogs (Canis familiaris) on an increasing number of odor discriminations in a controlled setting , 2002 .

[52]  W. J. Lewis,et al.  Comparison of detection ability of learned odors between males and females in the larval parasitoid Microplitis croceipes , 2007 .

[53]  J. Sparks,et al.  Effect of background interference on accelerant detection by canines. , 1996, Journal of forensic sciences.

[54]  Alastair D Pert,et al.  Review of Analytical Techniques for Arson Residues , 2006, Journal of forensic sciences.

[55]  T Sitalaximi,et al.  Autosomal microsatellite profile of three socially diverse ethnic Tamil populations of India. , 2003, Journal of forensic sciences.

[56]  Tom J. Griffin,et al.  A Multidisciplinary Approach to the Detection of Clandestine Graves , 1992 .

[57]  M. Laska,et al.  'Microsmatic' primates revisited: olfactory sensitivity in the squirrel monkey. , 2000, Chemical senses.

[58]  Kenneth G Furton,et al.  Detection of piperonal emitted from polymer controlled odor mimic permeation systems utilizing Canis familiaris and solid phase microextraction-ion mobility spectrometry. , 2010, Forensic science international.

[59]  K. Daly,et al.  Associative olfactory learning in the moth Manduca sexta. , 2000, The Journal of experimental biology.

[60]  M. Giurfa,et al.  Odour aversion after olfactory conditioning of the sting extension reflex in honeybees , 2009, Journal of Experimental Biology.

[61]  Stephen Trowell,et al.  Behavioural and Genetic Evidence for C. elegans' Ability to Detect Volatile Chemicals Associated with Explosives , 2010, PloS one.

[62]  T. Tomaszewski,et al.  Scent identification evidence in jurisdiction (drawing on the example of judicial practice in Poland). , 2006, Forensic science international.

[63]  Peter Kordos,et al.  A BIOFET ON THE BASIS OF INTACT INSECT ANTENNAE , 1998 .

[64]  Glen C. Rains,et al.  Behavioral monitoring of Microplitis croceipes, a parasitoid wasp, for detecting target odorants using a computer vision system , 2007 .

[65]  L. A. Carrell,et al.  Detection versus perception: physiological and behavioral analysis of olfactory sensitivity in the moth (Manduca sexta). , 2007, Behavioral neuroscience.

[66]  D. G. Moulton,et al.  The performance of dogs in detecting α-ionone in the vapor phase , 2004, Journal of comparative physiology.

[67]  L. Paul Waggoner,et al.  Canine detection odor signatures for explosives , 1998, Other Conferences.

[68]  Alanna E Lasseter,et al.  Cadaver dog and handler team capabilities in the recovery of buried human remains in the southeastern United States. , 2003, Journal of forensic sciences.

[69]  Ji Hee Ha,et al.  Chemical sensing of DNT by engineered olfactory yeast strain. , 2007, Nature chemical biology.

[70]  Junwei Zhu,et al.  Odor discrimination using insect electroantennogram responses from an insect antennal array. , 2002, Chemical senses.

[71]  Joseph Terkel,et al.  Domination of olfaction over vision in explosives detection by dogs , 2003 .

[72]  Aidan Kiely,et al.  Drosophila odorant receptors are novel seven transmembrane domain proteins that can signal independently of heterotrimeric G proteins. , 2008, Insect biochemistry and molecular biology.

[73]  J. H. Tumlinson,et al.  Herbivore-infested plants selectively attract parasitoids , 1998, Nature.

[74]  B. Slotnick,et al.  Odor detection thresholds in the rat for the vapors of three related perfluorocarbons and ethylene glycol dinitrate , 1981 .

[75]  John R. Carlson,et al.  Coding of Odors by a Receptor Repertoire , 2006, Cell.

[76]  L. Pott,et al.  Functional expression of odorant receptors of the zebrafish Danio rerio and of the nematode C. elegans in HEK293 cells. , 1997, Chemical senses.

[77]  E. H. Ashton,et al.  Olfactory Acuity in the Dog , 1957, Nature.

[78]  Michael Brown,et al.  Training rats to search and alert on contraband odors , 2002 .

[79]  W. J. Lewis,et al.  The effect of molecular structure on olfactory discrimination by the parasitoid Microplitis croceipes. , 2002, Chemical senses.

[80]  Ross J. Harper,et al.  Identification of dominant odor chemicals emanating from explosives for use in developing optimal training aid combinations and mimics for canine detection. , 2005, Talanta.

[81]  M. Hammer,et al.  Learning and memory in the honeybee , 1995 .

[82]  G A A Schoon,et al.  The effect of the ageing of crime scene objects on the results of scent identification line-ups using trained dogs. , 2005, Forensic science international.

[83]  D Komar,et al.  The use of cadaver dogs in locating scattered, scavenged human remains: preliminary field test results. , 1999, Journal of forensic sciences.

[84]  Susan Fae Ann Bender,et al.  Training and deployment of honeybees to detect explosives and other agents of harm , 2002, SPIE Defense + Commercial Sensing.

[85]  J. R. Riley,et al.  Design considerations for an harmonic radar to investigate the flight of insects at low altitude , 2002 .

[86]  W. J. Lewis,et al.  The role of learning in adult food location by the larval parasitoid,Microplitis croceipes (Hymenoptera: Braconidae) , 2005, Journal of Insect Behavior.

[87]  Arpad A Vass,et al.  Odor Analysis of Decomposing Buried Human Remains * , 2008, Journal of forensic sciences.

[88]  B. P. Halpern,et al.  Olfactory sensitivity to the pheromone, androstenone, is sexually dimorphic in the pig , 1995, Physiology & Behavior.

[89]  Lisa M Harvey,et al.  Reliability of bloodhounds in criminal investigations. , 2003, Journal of forensic sciences.

[90]  K. Takeda.  Classical conditioned response in the honey bee , 1961 .

[91]  R. Davis,et al.  Biochemistry of insect learning: lessons from bees and flies. , 1996, Insect biochemistry and molecular biology.

[92]  Humanitarian Demining,et al.  Mine Detection Dogs: Training, Operations and Odour Detection , 2003 .

[93]  L. J. Myers,et al.  The scientific foundation and efficacy of the use of canines as chemical detectors for explosives. , 2001, Talanta.

[94]  H. Robertson,et al.  The Gr family of candidate gustatory and olfactory receptors in the yellow-fever mosquito Aedes aegypti. , 2008, Chemical senses.

[95]  Brian H. Smith,et al.  Explosives detection with hard-wired moths , 2004, IEEE Transactions on Instrumentation and Measurement.

[96]  W. J. Lewis,et al.  Conditioning of appetitive behavior in the Hymenopteran parasitoid Microplitis croceipes , 2002 .

[97]  Beckers Rf,et al.  Studies on oltactory discrimination in dogs. II. Discriminatory behavior in a free environment. , 1962 .

[98]  K. Daly,et al.  Olfactory-based discrimination learning in the moth, Manduca sexta. , 2001, Journal of insect physiology.

[99]  Kenneth G. Furton,et al.  Laboratory and field experiments used to identify Canis lupus var. familiaris active odor signature chemicals from drugs, explosives, and humans , 2003, Analytical and bioanalytical chemistry.

[100]  G. Rains,et al.  Using insect sniffing devices for detection. , 2008, Trends in biotechnology.

[101]  L. Foster,et al.  A honey bee (Apis mellifera L.) PeptideAtlas crossing castes and tissues , 2011, BMC Genomics.