The protective role of ROS in autoimmune disease.

[1]  Wei-jian Zhang,et al.  Genetic deficiency of NADPH oxidase does not diminish, but rather enhances, LPS-induced acute inflammatory responses in vivo. , 2009, Free radical biology & medicine.

[2]  P. Gregersen,et al.  Rheumatoid arthritis: a view of the current genetic landscape , 2009, Genes and Immunity.

[3]  B. Röhrig,et al.  The protein tyrosine phosphatase non-receptor type 22 C1858T polymorphism is a joint susceptibility locus for immunthyroiditis and autoimmune diabetes. , 2009, Thyroid : official journal of the American Thyroid Association.

[4]  K. Berger,et al.  NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity , 2008, Malaria Journal.

[5]  M. Turner,et al.  Chronic granulomatous disease as a risk factor for autoimmune disease. , 2008, The Journal of allergy and clinical immunology.

[6]  Jing Chen,et al.  Role of Increased ROS Dissipation in Prevention of T1D , 2008, Annals of the New York Academy of Sciences.

[7]  S. Rosenzweig,et al.  NADPH oxidase controls phagosomal pH and antigen cross-presentation in human dendritic cells. , 2008, Blood.

[8]  K. Brown,et al.  Phagocyte-derived reactive oxygen species as suppressors of inflammatory disease. , 2008, Arthritis and rheumatism.

[9]  P. Ferguson,et al.  Neutrophil dysfunction in a family with a SAPHO syndrome-like phenotype. , 2008, Arthritis and rheumatism.

[10]  T. Merriman,et al.  Confirmation of association of IRGM and NCF4 with ileal Crohn's disease in a population-based cohort , 2008, Genes and Immunity.

[11]  Noel R Rose,et al.  Autoimmune thyroiditis and ROS. , 2008, Autoimmunity reviews.

[12]  M. Davies,et al.  Oxidative damage to extracellular matrix and its role in human pathologies. , 2008, Free radical biology & medicine.

[13]  R. Xavier,et al.  Redox signalling and the inflammatory response in rheumatoid arthritis , 2008, Clinical and experimental immunology.

[14]  K. Krause,et al.  NOX enzymes as novel targets for drug development , 2008, Seminars in Immunopathology.

[15]  K. Krause,et al.  Hyperinflammation in chronic granulomatous disease and anti-inflammatory role of the phagocyte NADPH oxidase , 2008, Seminars in Immunopathology.

[16]  I. Rahman,et al.  Cardiovascular , Pulmonary and Renal Pathology Genetic Ablation of NADPH Oxidase Enhances Susceptibility to Cigarette Smoke-Induced Lung Inflammation and Emphysema in Mice , 2010 .

[17]  E. Nygren,et al.  Th17 development and autoimmune arthritis in the absence of reactive oxygen species , 2008, European journal of immunology.

[18]  U. Grohmann,et al.  Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease , 2008, Nature.

[19]  C. Movitz,et al.  Oxygen radical production and severity of the Guillain–Barré syndrome , 2007, Journal of Neuroimmunology.

[20]  T. Sundqvist,et al.  Intracellular oxidative activation in synovial fluid neutrophils from patients with rheumatoid arthritis but not from other arthritis patients. , 2007, The Journal of rheumatology.

[21]  R. Holmdahl,et al.  Rheumatoid arthritis: the role of reactive oxygen species in disease development and therapeutic strategies. , 2007, Antioxidants & redox signaling.

[22]  E. Jury,et al.  Lipid rafts in T cell signalling and disease , 2007, Seminars in cell & developmental biology.

[23]  R. Holmdahl,et al.  Macrophages suppress T cell responses and arthritis development in mice by producing reactive oxygen species. , 2007, The Journal of clinical investigation.

[24]  L. Alfredsson,et al.  A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity , 2007, Arthritis research & therapy.

[25]  D. Corella,et al.  A novel CYBA variant, the –675A/T polymorphism, is associated with essential hypertension , 2007, Journal of hypertension.

[26]  R. Holmdahl,et al.  Lack of Reactive Oxygen Species Breaks T Cell Tolerance to Collagen Type II and Allows Development of Arthritis in Mice1 , 2007, The Journal of Immunology.

[27]  Judy H Cho,et al.  Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis , 2007, Nature Genetics.

[28]  Huey-Lan Huang,et al.  Reactive oxygen species promote raft formation in T lymphocytes. , 2007, Free radical biology & medicine.

[29]  D. Goldblatt,et al.  Cutaneous and other lupus‐like symptoms in carriers of X‐linked chronic granulomatous disease: incidence and autoimmune serology , 2007, Clinical and experimental immunology.

[30]  Lars Alfredsson,et al.  Smoking as a trigger for inflammatory rheumatic diseases , 2007, Current opinion in rheumatology.

[31]  K. Krause,et al.  The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. , 2007, Physiological reviews.

[32]  R. Holmdahl,et al.  Arthritis suppression by NADPH activation operates through an interferon-β pathway , 2007, BMC Biology.

[33]  G. Buettner,et al.  Ascorbate Reacts with Singlet Oxygen to Produce Hydrogen Peroxide , 2006, Photochemistry and photobiology.

[34]  R. Holmdahl,et al.  A New Arthritis Therapy with Oxidative Burst Inducers , 2006, PLoS medicine.

[35]  R. Holmdahl,et al.  T cell surface redox levels determine T cell reactivity and arthritis susceptibility , 2006, Proceedings of the National Academy of Sciences.

[36]  P. Hawkins,et al.  Neutrophils from p40phox−/− mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing , 2006, The Journal of experimental medicine.

[37]  G. Raposo,et al.  NOX2 Controls Phagosomal pH to Regulate Antigen Processing during Crosspresentation by Dendritic Cells , 2006, Cell.

[38]  T. Hussell,et al.  An absence of reactive oxygen species improves the resolution of lung influenza infection , 2006, European journal of immunology.

[39]  H. Koyama,et al.  Earlier onset of neutrophil-mediated inflammation in the ultraviolet-exposed skin of mice deficient in myeloperoxidase and NADPH oxidase , 2006, Inflammation Research.

[40]  Michael Platten,et al.  Treatment of Autoimmune Neuroinflammation with a Synthetic Tryptophan Metabolite , 2005, Science.

[41]  A. Levine,et al.  Redox Equilibrium in Mucosal T Cells Tunes the Intestinal TCR Signaling Threshold1 , 2005, The Journal of Immunology.

[42]  J. Keenan,et al.  NADPH oxidase involvement in the pathology of Helicobacter pylori infection. , 2005, Free radical biology & medicine.

[43]  P. Chiarugi ReviewPTPs versus PTKs: The redox side of the coin , 2005, Free radical research.

[44]  R. Holmdahl,et al.  Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[45]  Steven J. Schrodi,et al.  A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. , 2004, American journal of human genetics.

[46]  Daniel Offen,et al.  The role of oxidative stress in the pathogenesis of multiple sclerosis: The need for effective antioxidant therapy , 2004, Journal of Neurology.

[47]  O. Meyer,et al.  NADPH Oxidase Priming and p47phox Phosphorylation in Neutrophils from Synovial Fluid of Patients with Rheumatoid Arthritis and Spondylarthropathy , 2002, Inflammation.

[48]  H. C. Mehta,et al.  Antioxidant status in rheumatoid arthritis and role of antioxidant therapy. , 2003, Clinica chimica acta; international journal of clinical chemistry.

[49]  B. Aronow,et al.  Control of Bcl-2 expression by reactive oxygen species , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[50]  Y. Henrotin,et al.  The role of reactive oxygen species in homeostasis and degradation of cartilage. , 2003, Osteoarthritis and cartilage.

[51]  P. Heyworth,et al.  Chronic granulomatous disease. , 2003, Current opinion in immunology.

[52]  L. Joosten,et al.  Deficiency of NADPH oxidase components p47phox and gp91phox caused granulomatous synovitis and increased connective tissue destruction in experimental arthritis models. , 2003, The American journal of pathology.

[53]  L. Dekker,et al.  Lipid rafts determine efficiency of NADPH oxidase activation in neutrophils , 2003, FEBS letters.

[54]  R. Redline,et al.  Severe inflammation and reduced bacteria load in murine helicobacter infection caused by lack of phagocyte oxidase activity. , 2003, The Journal of infectious diseases.

[55]  Hidekazu Hiroaki,et al.  Phosphorylation of p47phox directs phox homology domain from SH3 domain toward phosphoinositides, leading to phagocyte NADPH oxidase activation , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[56]  Jens Holmberg,et al.  Positional identification of Ncf1 as a gene that regulates arthritis severity in rats , 2003, Nature Genetics.

[57]  A. Akhand,et al.  Redox-linked signal transduction pathways for protein tyrosine kinase activation. , 2002, Antioxidants & redox signaling.

[58]  Giorgio Gabella,et al.  Killing activity of neutrophils is mediated through activation of proteases by K+ flux , 2002, Nature.

[59]  J. Pincemail,et al.  Vitamin E uncouples joint destruction and clinical inflammation in a transgenic mouse model of rheumatoid arthritis. , 2002, Arthritis and rheumatism.

[60]  E. Ostrakhovitch,et al.  Oxidative stress in rheumatoid arthritis leukocytes: suppression by rutin and other antioxidants and chelators. , 2001, Biochemical pharmacology.

[61]  A. Cantagrel,et al.  A potential role for protein tyrosine kinase p56(lck) in rheumatoid arthritis synovial fluid T lymphocyte hyporesponsiveness. , 2001, International immunology.

[62]  K. Schulze-Osthoff,et al.  Enhancement of T Cell Receptor Signaling by a Mild Oxidative Shift in the Intracellular Thiol Pool1 , 2000, The Journal of Immunology.

[63]  R. C. van der Veen,et al.  Superoxide Prevents Nitric Oxide-Mediated Suppression of Helper T Lymphocytes: Decreased Autoimmune Encephalomyelitis in Nicotinamide Adenine Dinucleotide Phosphate Oxidase Knockout Mice1 , 2000, The Journal of Immunology.

[64]  Richard B. Johnston,et al.  Chronic Granulomatous Disease: Report on a National Registry of 368 Patients , 2000, Medicine.

[65]  S. Holland,et al.  Genetic, biochemical, and clinical features of chronic granulomatous disease. , 2000, Medicine.

[66]  F. Breedveld,et al.  Displacement of Linker for Activation of T Cells from the Plasma Membrane Due to Redox Balance Alterations Results in Hyporesponsiveness of Synovial Fluid T Lymphocytes in Rheumatoid Arthritis , 2000, The Journal of Immunology.

[67]  L. Zhan,et al.  P47phox ‐deficient NADPH oxidase defect in neutrophils of diabetic mouse strains, C57BL/6J‐m db/db and db/+ , 2000, Journal of leukocyte biology.

[68]  E. Mazzon,et al.  Beneficial effects of tempol, a membrane-permeable radical scavenger, in a rodent model of collagen-induced arthritis. , 2000, Arthritis and rheumatism.

[69]  J. Venkatraman,et al.  Effects of Dietary ω-3 and ω-6 Lipids and Vitamin E on Serum Cytokines, Lipid Mediators and Anti-DNA Antibodies in a Mouse Model for Rheumatoid Arthritis , 1999 .

[70]  M. Tassabehji,et al.  A complete physical contig and partial transcript map of the Williams syndrome critical region. , 1999, Genomics.

[71]  B. Babior NADPH oxidase: an update. , 1999, Blood.

[72]  D. Williams,et al.  Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense. , 1999, Immunity.

[73]  E. Green,et al.  A p47-phox pseudogene carries the most common mutation causing p47-phox- deficient chronic granulomatous disease. , 1997, The Journal of clinical investigation.

[74]  Wilder Rl Adrenal and gonadal steroid hormone deficiency in the pathogenesis of rheumatoid arthritis. , 1996 .

[75]  F. Rossi,et al.  Mechanisms of NADPH oxidase activation: translocation of p40phox, Rac1 and Rac2 from the cytosol to the membranes in human neutrophils lacking p47phox or p67phox. , 1996, The Biochemical journal.

[76]  P. Eggleton,et al.  Differences in oxidative response of subpopulations of neutrophils from healthy subjects and patients with rheumatoid arthritis. , 1995, Annals of the rheumatic diseases.

[77]  S. Holland,et al.  The p47phox mouse knock-out model of chronic granulomatous disease , 1995, The Journal of experimental medicine.

[78]  David A. Williams,et al.  Mouse model of X–linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production , 1995, Nature Genetics.

[79]  H. Yap,et al.  Polyarthritis resembling juvenile rheumatoid arthritis in a girl with chronic granulomatous disease. , 1994, Arthritis and rheumatism.

[80]  D. Bentley,et al.  Characterization of the 47-kilodalton autosomal chronic granulomatous disease protein: tissue-specific expression and transcriptional control by retinoic acid , 1990, Molecular and cellular biology.

[81]  A. Carvalho,et al.  [Chronic granulomatous disease]. , 1973, AMB : revista da Associacao Medica Brasileira.

[82]  R. Good,et al.  The pattern of genetic transmission of the leukocyte defect in fatal granulomatous disease of childhood. , 1968, The Journal of clinical investigation.