Schemes of microwave hyperthermia by using flat left‐handed material lenses

Effective microwave hyperthermia of cancer is proposed by using slightly lossy flat left-handed material lenses. High-resolution focusing of microwave without any auxiliary foci can be achieved in tissue by jointly adjusting the sources behind the flat lenses. Two-dimensional numerical simulations demonstrate that, for tumor of diameter of 0.6 cm immersed in lossy breast tissue, microwave power can be effectively localized in tumor volume and temperature in tumor may be raised to ∼43.5°C, while keeps below 42°C in the surrounding normal tissue as required in hyperthermia treatment. The proposed Γ-shaped two-lens system is proved to an efficient scheme for microwave hyperthermia. © 2009 Wiley Periodicals, Inc. Microwave Opt Technol Lett 51: 1738–1743, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24449

[1]  Nicholas X. Fang,et al.  Imaging properties of a metamaterial superlens , 2003 .

[2]  X S Rao,et al.  Subwavelength imaging by a left-handed material superlens. , 2003, Physical review. E, Statistical, nonlinear, and soft matter physics.

[3]  Paolo Bernardi,et al.  Specific absorption rate and temperature elevation in a subject exposed in the far-field of radio-frequency sources operating in the 10-900-MHz range , 2003, IEEE Transactions on Biomedical Engineering.

[4]  T. Cui,et al.  Enhancement of specific absorption rate in lossy dielectric objects using a slab of left-handed material. , 2005, Physical review. E, Statistical, nonlinear, and soft matter physics.

[5]  D Machin,et al.  Radiotherapy with or without hyperthermia in the treatment of superficial localized breast cancer: results from five randomized controlled trials. International Collaborative Hyperthermia Group. , 1996, International journal of radiation oncology, biology, physics.

[6]  O. S. Nielsen,et al.  A future for hyperthermia in cancer treatment? , 2001, European journal of cancer.

[7]  Yuri S. Kivshar,et al.  Sub-wavelength Imaging with a Left-handed Material Flat Lens , 2005 .

[8]  Steven A. Cummer,et al.  Simulated causal subwavelength focusing by a negative refractive index slab , 2003 .

[9]  A. Taflove,et al.  Two-dimensional FDTD analysis of a pulsed microwave confocal system for breast cancer detection: fixed-focus and antenna-array sensors , 1998, IEEE Transactions on Biomedical Engineering.

[10]  K. Aydin,et al.  Focusing of electromagnetic waves by a left-handed metamaterial flat lens. , 2005, Optics express.

[11]  L. Barratt,et al.  Experimental validation of a combined electromagnetic and thermal FDTD model of a microwave heating process , 1995 .

[12]  Srinivas Sridhar,et al.  Photonic crystals: Imaging by flat lens using negative refraction , 2003, Nature.

[13]  J. Pendry,et al.  Negative refraction makes a perfect lens , 2000, Physical review letters.

[14]  B.D. Van Veen,et al.  Ultrawide-band microwave space-time beamforming for hyperthermia treatment of breast cancer: a computational feasibility study , 2004, IEEE Transactions on Microwave Theory and Techniques.

[15]  Gang Wang,et al.  Resolution of Near-Field Microwave Target Detection and Imaging by Using Flat LHM Lens , 2007, IEEE Transactions on Antennas and Propagation.

[16]  P. Wust,et al.  Hyperthermia in combined treatment of cancer. , 2002, The Lancet Oncology.

[17]  D. Kapp,et al.  Efficacy of adjuvant hyperthermia in the treatment of superficial recurrent breast cancer: confirmation and future directions. , 1996, International journal of radiation oncology, biology, physics.

[18]  A. Lagarkov,et al.  Near-perfect imaging in a focusing system based on a left-handed-material plate. , 2004, Physical review letters.

[19]  Jung-Tsung Shen,et al.  Near field imaging with negative dielectric constant lenses , 2002 .

[20]  A. Grbic,et al.  Overcoming the diffraction limit with a planar left-handed transmission-line lens. , 2004, Physical review letters.