Application of two- and three-way chemometric methods in the study of acetylsalicylic acid and ascorbic acid mixtures using ultraviolet spectrophotometry

AbstractIn this work, mixtures of acetylsalicylic acid (ASA) and ascorbic acid (AA) were studied by ultraviolet spectrophotometry(210–300nm) using parallel factor analysis (PARAFAC) and partial least square (PLS). The study was carried out in thepH range from 1.0 to 5.5 and with a concentration range from 1.0 −10 5 to 1.0 10 −4 moll −1 of both analytes. PARAFACwas used for spectra deconvolution, pK a estimation for both acids and to check the presence of salicylic acid (SA), dueto the possible ASA decomposition. The estimated first p K a was equal to 3.41 and 4.10 for ASA and AA, respectively.Multivariate calibration models using PLS at different pH and N-way PLS were elaborated for simultaneous determination ofASA and AA in pharmaceutical samples. The best models for the system were obtained with N-way PLS2 and PLS2 at pH1.1. The results obtained for simultaneous determination of ASA and AA in samples were in agreement to the values specifiedby the manufacturers and the recovery was between 97.6 and 103.6%. Nevertheless, these models failed to predict ASAdecomposition to SA in simulated samples. Thus, a new PLS-pH1 model considering SA was built and applied successfullyin simulated samples. ©2000 Elsevier Science B.V. All rights reserved.

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