Application of thermospray liquid chromatography/mass spectrometry for determination of organophosphorus pesticides and trialkyl and triaryl phosphates.

The characterization of several organophosphorus compounds was achieved by utilizing positive and negative ion 'filament-on' thermospray liquid chromatography/mass spectrometry. In the positive ion mode, the base peak was [M + NH4]+ for all the studied compounds, while in the negative ion mode the organophosphorus pesticides exhibited different fragmentation behaviour, such as electron capture, dissociative electron capture and anion attachment. The positive ion mode showed, for all the organophosphorus compounds, higher sensitivity than the negative ion mode. In the positive ion mode, detection limits at the low nanogram level were achieved for the trialkyl and triaryl phosphates, similar to gas chromatography/positive chemical ionization mass spectrometry with ammonia as reagent gas. The organophosphorus pesticides exhibited detection limits slightly lower than the phosphates, but with values similar to those previously observed in direct liquid introduction liquid chromatography/negative chemical ionization mass spectrometry. Applications of positive and negative ion analysis are reported for the determination of malathion in a fish sample.

[1]  G. J. Jong,et al.  Determination of Trialkyl and Triaryl Phosphates by Narrow-bore Liquid Chromatography with On-line Thermionic Detection , 1987 .

[2]  S. Lammert,et al.  Techniques for increased use of thermospray liquid chromatography—mass spectrometry , 1987 .

[3]  M. M. Bursey,et al.  Eluent pH and thermospray mass spectra: does the charge on the ion in solution influence the mass spectrum? , 1987 .

[4]  F. Röllgen,et al.  Studies with a dual-beam thermospray interface in high-performance liquid chromatography—mass spectrometry , 1987 .

[5]  D. Garteiz,et al.  Thermospray collisionally induced dissociation with single and multiple mass analyzers. , 1987, Journal of chromatography.

[6]  R. W. Frei,et al.  Comparison between positive, negative and chloride-enhanced negative chemical ionization of organophosphorus pesticides in on-line liquid chromatography-mass spectrometry. , 1987, Journal of chromatography.

[7]  S. Gaskell,et al.  Dependence of ion formation upon the ionic additive in thermospray liquid chromatography/negative ion mass spectrometry. , 1986, Analytical chemistry.

[8]  P. D'agostino,et al.  Capillary column ammonia chemical ionization mass spectrometry of organophosphorus chemical warfare agents and simulants , 1986 .

[9]  P. Kebarle,et al.  Thermospray mass spectrometry. Use of gas-phase ion/molecule reactions to explain features of thermospray mass spectra , 1986 .

[10]  G. J. Jong,et al.  Improved design and applications of an on-line thermionic detector for narrow-bore liquid chromatography , 1986 .

[11]  R. Snelling,et al.  Chromatographic identification of pesticides. , 1986, Journal of chromatography.

[12]  S. Gaskell,et al.  Gas-phase ionization of selected neutral analytes during thermospray liquid chromatography/mass spectrometry. , 1985, Analytical chemistry.

[13]  G. Clark,et al.  Comparison of ultraviolet and reductive amperometric detection for determination of ethyl and methyl parathion in green vegetables and surface water using high-performance liquid chromatography. , 1985, Analytical chemistry.

[14]  R. Voyksner,et al.  Optimization and application of thermospray high-performance liquid chromatography/mass spectrometry , 1985 .

[15]  J. Henion,et al.  Thermospray liquid chromatography/mass spectrometry determination of drugs and their metabolites in biological fluids. , 1985, Analytical chemistry.

[16]  A. Hill,et al.  Organophosphorus sulphides, sulphoxides and sulphones. Part 2. Characterisation by gas chromatography-mass spectrometry , 1985 .

[17]  S. Priebe,et al.  Post-column reaction detection system for the determination of organophosphorus compounds by liquid chromatography. , 1985, Journal of chromatography.

[18]  C. Fenselau,et al.  Comparison of thermospray and fast atom bombardment mass spectrometry as solution-dependent ionization techniques. , 1984, Analytical chemistry.

[19]  R. Agneessens,et al.  Analysis of Pesticide-residues By High-resolution Gas-chromatography .1. Comparison Between Packed and Capillary Columns in Pesticide-residue Determinations - Practical Considerations for Routine Use of Capillary Gas-chromatography , 1984 .

[20]  E. Pellizzari,et al.  Postcolumn addition of buffer for thermospray liquid chromatography/mass spectrometry identification of pesticides , 1984 .

[21]  R. H. Zienius,et al.  Column temperature effects on gas chromatography responses to organophosphorus pesticides , 1983 .

[22]  H. Stan,et al.  Negative chemical ionization mass spectrometry of organophosphorus pesticides , 1982 .

[23]  J. Hass,et al.  High-performance liquid chromatography-negative chemical ionization mass spectrometry of organophosphorus pesticides , 1982 .

[24]  P. Tittarelli,et al.  High-performance liquid chromatography with graphite furnace atomic absorption spectrometric detector for speciation of organophosphorus compounds , 1981 .

[25]  R. Dougherty,et al.  Positive and negative chemical ionization mass spectra of some aromatic chlorinated pesticides. , 1975, Analytical chemistry.