L-proline catalyzed an efficient multicomponent one -pot synthesis of poly substituted pyridines

A series of poly substituted pyridines (3,11-disu bstituted-7-aryl-5,6,8,9-tetrahydro- dibenzo( c,h )acridines) were synthesized by the multicomponent condensation of 6-substituted-1-tetralone, aromatic aldehydes and ammonium acetate in ethanol using L-proline as an efficient organocatalyst. Thi s methodology is mild, efficient, high yielding and t he catalyst is inexpensive, easily recovered from t he reaction mixture and reused for five times without losing it s activity.

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