The error-related negativity is related to risk taking and empathy in young men.

We related self-report measures of risk taking and empathy to the error-related negativity (ERN) elicited during a flanker task in boys in late adolescence. We found that risk propensity (risk taking, sensation seeking, and sensitivity to reward) and empathy related to ERN amplitude (negatively and positively, respectively) but not to each other or to behavioral measures of response time, accuracy, and post-error slowing. They accounted for separate sources of variance in the ERN amplitude, suggesting that there are multiple routes to activation of its generator in the anterior cingulate. Impulsivity and sensitivity to punishment were unrelated to the ERN. The present study provides support that risk-taking traits and empathy affect anterior cingulate responsiveness to errors, and the ERN reflects the influence of the extent of individuals' concern with the outcome of events.

[1]  M. Spinella,et al.  Prefrontal substrates of empathy: Psychometric evidence in a community sample , 2005, Biological Psychology.

[2]  C. R. Cloninger,et al.  A psychobiological model of temperament and character. , 1993, Archives of general psychiatry.

[3]  R. Handa,et al.  Androgen inhibits neurotransmitter turnover in the medial prefrontal cortex of the rat following exposure to a novel environment , 1997, Brain Research.

[4]  G. Harris,et al.  ERN varies with degree of psychopathy in an emotion discrimination task , 2007, Biological Psychology.

[5]  A. Dale,et al.  Dorsal anterior cingulate cortex: A role in reward-based decision making , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[6]  J. Newman,et al.  Reaction to punishment in extraverts and psychopaths: Implications for the impulsive behavior of disinhibited individuals , 1987 .

[7]  Clay B. Holroyd,et al.  Sensitivity of electrophysiological activity from medial frontal cortex to utilitarian and performance feedback. , 2004, Cerebral cortex.

[8]  H. Soderstrom,et al.  Psychopathy as a disorder of empathy , 2003, European Child & Adolescent Psychiatry.

[9]  Francis X. Archambault,et al.  Cognitive flexibility and empathy after frontal lobe lesion. , 1994 .

[10]  S. Segalowitz,et al.  ERP correlates of error monitoring in 10-year olds are related to socialization , 2005, Biological Psychology.

[11]  William D. Schafer,et al.  Gender differences in risk taking: A meta-analysis. , 1999 .

[12]  F Brambilla,et al.  Neuroendocrine correlates of temperamental traits in humans , 2000, Psychoneuroendocrinology.

[13]  B. Vogt,et al.  Contributions of anterior cingulate cortex to behaviour. , 1995, Brain : a journal of neurology.

[14]  J. Allen,et al.  Error monitoring during reward and avoidance learning in high- and low-socialized individuals. , 2000, Psychophysiology.

[15]  D. Schalling,et al.  On the Validity of the California Psychological Inventory Socialization Scale: A Multivariate Approach. , 1974 .

[16]  Reduced electrodermal response to conflict, failure to inhibit dominant behaviors, and delinquency proneness. , 1982, Journal of personality and social psychology.

[17]  H. Meltzer,et al.  The effects of clozapine, risperidone, and olanzapine on cognitive function in schizophrenia. , 1999, Schizophrenia bulletin.

[18]  J. Hohnsbein,et al.  Effects of crossmodal divided attention on late ERP components. II. Error processing in choice reaction tasks. , 1991, Electroencephalography and clinical neurophysiology.

[19]  H. Gough.  Theory, Development, and Interpretation of the CPI Socialization Scale , 1994, Psychological reports.

[20]  M. Posner,et al.  Localization of a Neural System for Error Detection and Compensation , 1994 .

[21]  A. Abu-Akel,et al.  The neurochemical hypothesis of 'theory of mind'. , 2003, Medical hypotheses.

[22]  R. Crum,et al.  Sensation seeking needs among 8th and 11th graders: characteristics associated with cigarette and marijuana use. , 2001, Drug and alcohol dependence.

[23]  J. O'Doherty,et al.  Empathy for Pain Involves the Affective but not Sensory Components of Pain , 2004, Science.

[24]  R. Depue,et al.  Neurobiology of the structure of personality: Dopamine, facilitation of incentive motivation, and extraversion , 1999, Behavioral and Brain Sciences.

[25]  R. Blair,et al.  The psychopathic individual: a lack of responsiveness to distress cues? , 1997, Psychophysiology.

[26]  P. Eslinger,et al.  Empathy and social‐emotional factors in recovery from stroke , 2002, Current opinion in neurology.

[27]  W. Gehring,et al.  Action-Monitoring Dysfunction in Obsessive-Compulsive Disorder , 2000, Psychological science.

[28]  R. Simons,et al.  Error-related brain activity in obsessive–compulsive undergraduates , 2002, Psychiatry Research.

[29]  Michael T. Bardo,et al.  Conditioned increase in place preference by access to novel objects: antagonism by MK-801 , 1999, Behavioural Brain Research.

[30]  Susan M. Moore,et al.  Predicting adolescent risk behavior using a personalized cost-benefit analysis , 1996 .

[31]  C. Batson.  The Altruism Question: Toward A Social-psychological Answer , 1991 .

[32]  C. Robert Cloninger.  A systematic method for clinical description and classification of personality variants. A proposal. , 1987, Archives of general psychiatry.

[33]  Hans J. Eysenck,et al.  Dimensions of personality: The biosocial approach to personality. , 1991 .

[34]  D. Kahneman,et al.  Functional Imaging of Neural Responses to Expectancy and Experience of Monetary Gains and Losses tasks with monetary payoffs , 2001 .

[35]  Adrian R. Willoughby,et al.  The Medial Frontal Cortex and the Rapid Processing of Monetary Gains and Losses , 2002, Science.

[36]  E. Megargee,et al.  The California psychological inventory handbook , 1972 .

[37]  D L Rubin,et al.  Targeting adolescent risk-taking behaviors: the contributions of egocentrism and sensation-seeking. , 2000, Journal of adolescence.

[38]  E. Barratt,et al.  Reduced punishment sensitivity in neural systems of behavior monitoring in impulsive individuals , 2006, Neuroscience Letters.

[39]  M. Botvinick,et al.  Anterior cingulate cortex, error detection, and the online monitoring of performance. , 1998, Science.

[40]  C. Eriksen,et al.  Effects of noise letters upon the identification of a target letter in a nonsearch task , 1974 .

[41]  Peter Dayan,et al.  A Neural Substrate of Prediction and Reward , 1997, Science.

[42]  G. Pison,et al.  Peripheral Markers of Serotonergic and Noradrenergic Function in Post-Pubertal, Caucasian Males with Autistic Disorder , 2000, Neuropsychopharmacology.

[43]  A. Bechara,et al.  Decision-making and addiction (part II): myopia for the future or hypersensitivity to reward? , 2002, Neuropsychologia.

[44]  R. Bevins.  Novelty Seeking and Reward: Implications for the Study of High-Risk Behaviors , 2001 .

[45]  Sidney J Segalowitz,et al.  The error-related negativity as a state and trait measure: motivation, personality, and ERPs in response to errors. , 2004, Psychophysiology.

[46]  H. Eysenck,et al.  Psychoticism as a dimension of personality , 1976 .

[47]  Rebecca Elliott,et al.  Neuronal correlates of theory of mind and empathy: A functional magnetic resonance imaging study in a nonverbal task , 2006, NeuroImage.

[48]  B. Gold,et al.  Functional Dissociation in Frontal and Striatal Areas for Processing of Positive and Negative Reward Information , 2007, The Journal of Neuroscience.

[49]  J. Gilmore,et al.  Clomipramine challenge responses covary with tridimensional personality questionnaire scores in healthy subjects , 1997, Biological Psychiatry.

[50]  D. Dietrich,et al.  Discrepant target detection and action monitoring in obsessive–compulsive disorder , 2001, Psychiatry Research: Neuroimaging.

[51]  Cloninger Cr.  A systematic method for clinical description and classification of personality variants: A proposal. , 1987 .

[52]  W. Revelle.  Personality Processes , 2002 .

[53]  Stephen D. Hart,et al.  The revised Psychopathy Checklist: Reliability and factor structure. , 1990 .

[54]  M. Coles,et al.  Where did I go wrong , 1995 .

[55]  Linda Mealey,et al.  The sociobiology of sociopathy: An integrated evolutionary model , 1995 .

[56]  J. Arnett,et al.  Still crazy after all these years: Reckless behavior among young adults aged 23–27 , 1991 .

[57]  P. Costa,et al.  Normal Personality Assessment in Clinical Practice: The NEO Personality Inventory. , 1992 .

[58]  C. Ávila,et al.  The Sensitivity to Punishment and Sensitivity to Reward Questionnaire (SPSRQ) as a measure of Gray's anxiety and impulsivity dimensions. , 2001 .

[59]  H. Cleckley.  The Mask of Sanity: An Attempt to Clarify Some Issues about the So-called Psychopathic Personality , 1976 .

[60]  G. Glover,et al.  Risk-taking and the adolescent brain: who is at risk? , 2007, Developmental science.

[61]  R. Edelmann,et al.  Further analysis of the social psychopathy scale , 1988 .

[62]  Fool me once, shame on me—fool me twice, blame the ACC , 2006, Nature Neuroscience.

[63]  M. Kritzer,et al.  Ovarian hormones differentially influence immunoreactivity for dopamine β‐ hydroxylase, choline acetyltransferase, and serotonin in the dorsolateral prefrontal cortex of adult rhesus monkeys , 1999, The Journal of comparative neurology.

[64]  J. Sobral,et al.  Personality and antisocial behaviour: study of temperamental dimensions , 2001 .

[65]  K. Fromme,et al.  Outcome Expectancies and Risk-Taking Behavior , 2004, Cognitive Therapy and Research.

[66]  Stevens S. Smith,et al.  Evaluating the construct validity of psychopathy in black and white male inmates: three preliminary studies. , 1990, Journal of abnormal psychology.

[67]  B. Berger,et al.  Characterization of Empathy Deficits following Prefrontal Brain Damage: The Role of the Right Ventromedial Prefrontal Cortex , 2003, Journal of Cognitive Neuroscience.

[68]  J. Hollerman,et al.  Reward processing in primate orbitofrontal cortex and basal ganglia. , 2000, Cerebral cortex.

[69]  B. Sherwin.  Affective changes with estrogen and androgen replacement therapy in surgically menopausal women. , 1988, Journal of affective disorders.

[70]  Graham Leslie Bradley,et al.  Psychosocial Predictors of Emerging Adults' Risk and Reckless Behaviors , 2002 .

[71]  M. Delgado,et al.  Event-related functional magnetic resonance imaging of reward-related brain circuitry in children and adolescents , 2004, Biological Psychiatry.

[72]  S. Segalowitz,et al.  The error negativity in nonmedicated and medicated patients with Parkinson’s disease , 2007, Clinical Neurophysiology.

[73]  Timothy E. J. Behrens,et al.  Optimal decision making and the anterior cingulate cortex , 2006, Nature Neuroscience.

[74]  Simon Baron-Cohen,et al.  The Essential Difference , 2003 .

[75]  S. Baron-Cohen,et al.  Measuring empathy: reliability and validity of the Empathy Quotient , 2004, Psychological Medicine.

[76]  S. Moss,et al.  The Adolescent Risk-Taking Questionnaire , 2000 .

[77]  S. Baron-Cohen,et al.  The Empathy Quotient: An Investigation of Adults with Asperger Syndrome or High Functioning Autism, and Normal Sex Differences , 2004, Journal of autism and developmental disorders.

[78]  J. Aharon-Peretz,et al.  Impairment in Cognitive and Affective Empathy in Patients with Brain Lesions: Anatomical and Cognitive Correlates , 2004, Journal of clinical and experimental neuropsychology.

[79]  J. Patton,et al.  Factor structure of the Barratt impulsiveness scale. , 1995, Journal of clinical psychology.

[80]  M. Botvinick,et al.  Conflict monitoring and cognitive control. , 2001, Psychological review.

[81]  Johannes Hewig,et al.  Decision-making in Blackjack: an electrophysiological analysis. , 2007, Cerebral cortex.

[82]  M. Zuckerman,et al.  Personality and risk-taking: common biosocial factors. , 2000, Journal of personality.

[83]  Michael J. Frank,et al.  Error-Related Negativity Predicts Reinforcement Learning and Conflict Biases , 2005, Neuron.

[84]  M. Holzbauer.  Physiological aspects of steroids with anaesthetic properties. , 1976, Medical biology.

[85]  P. Frick,et al.  Callous-Unemotional Traits and Subtypes of Conduct Disorder , 1999, Clinical child and family psychology review.

[86]  N. Yeung,et al.  On the ERN and the significance of errors. , 2005, Psychophysiology.

[87]  M. Herrmann,et al.  Source localization (LORETA) of the error-related-negativity (ERN/Ne) and positivity (Pe). , 2004, Brain research. Cognitive brain research.

[88]  Clay B. Holroyd,et al.  The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity. , 2002, Psychological review.

[89]  P. Venables,et al.  Electrodermal nonresponding, antisocial behavior, and schizoid tendencies in adolescents. , 1984, Psychophysiology.

[90]  J. Arnett.  Sensation seeking, aggressiveness, and adolescent reckless behavior. , 1996 .

[91]  C. Carter,et al.  The Timing of Action-Monitoring Processes in the Anterior Cingulate Cortex , 2002, Journal of Cognitive Neuroscience.

[92]  D. Tucker,et al.  Mood, personality, and self-monitoring: negative affect and emotionality in relation to frontal lobe mechanisms of error monitoring. , 2000, Journal of experimental psychology. General.

[93]  S. Segalowitz,et al.  Charting the maturation of the frontal lobe: An electrophysiological strategy , 2004, Brain and Cognition.

[94]  M. Zuckerman.  Behavioral Expressions and Biosocial Bases of Sensation Seeking , 1994 .

[95]  N. Ramnani,et al.  Distinct portions of anterior cingulate cortex and medial prefrontal cortex are activated by reward processing in separable phases of decision-making cognition , 2004, Biological Psychiatry.

[96]  A. Sanfey,et al.  Independent Coding of Reward Magnitude and Valence in the Human Brain , 2004, The Journal of Neuroscience.

[97]  J. Reggers,et al.  Further evidence on the relationship between dopamine and novelty seeking: a neuroendocrine study , 2002 .