3-O-Substituted-3',4',5'-trimethoxyflavonols: Synthesis and cell-based evaluation as anti-prostate cancer agents.

[1]  Shenmin Zhang,et al.  Flavonoids with Therapeutic Potential in Prostate Cancer. , 2016, Anti-cancer agents in medicinal chemistry.

[2]  Shilong Zheng,et al.  A new class of flavonol-based anti-prostate cancer agents: Design, synthesis, and evaluation in cell models. , 2016, Bioorganic & medicinal chemistry letters.

[3]  L. Howells,et al.  Inhibition of prostate cancer cell growth by 3′,4′,5′-trimethoxyflavonol (TMFol) , 2015, Cancer Chemotherapy and Pharmacology.

[4]  J. Arunakaran,et al.  Quercetin, a natural dietary flavonoid, acts as a chemopreventive agent against prostate cancer in an in vivo model by inhibiting the EGFR signaling pathway. , 2014, Food & function.

[5]  F. Estévez,et al.  Synthesis and effects on cell viability of flavonols and 3-methyl ether derivatives on human leukemia cells. , 2014, European journal of medicinal chemistry.

[6]  M. F. Proença,et al.  Superior anticancer activity of halogenated chalcones and flavonols over the natural flavonol quercetin. , 2013, European journal of medicinal chemistry.

[7]  Xianglin Shi,et al.  Quercetin Inhibits Angiogenesis Mediated Human Prostate Tumor Growth by Targeting VEGFR- 2 Regulated AKT/mTOR/P70S6K Signaling Pathways , 2012, PloS one.

[8]  P. R. Jenkins,et al.  Synthesis and biological evaluation of novel flavonols as potential anti-prostate cancer agents. , 2012, European journal of medicinal chemistry.

[9]  Donald J L Jones,et al.  Tissue distribution and metabolism of the putative cancer chemopreventive agent 3',4',5'-trimethoxyflavonol (TMFol) in mice. , 2012, Biomedical chromatography : BMC.

[10]  T. Ozturk,et al.  Facile syntheses of 3-hydroxyflavones. , 2012, Organic letters.

[11]  Hong Yang,et al.  Vitexicarpin induces apoptosis in human prostate carcinoma PC-3 cells through G2/M phase arrest. , 2012, Asian Pacific journal of cancer prevention : APJCP.

[12]  J. Rhim,et al.  Novel human prostate epithelial cell culture models for the study of carcinogenesis and of normal stem cells and cancer stem cells. , 2011, Advances in experimental medicine and biology.

[13]  L. Klotz,et al.  Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells , 2010, Nutrition and cancer.

[14]  H. Mukhtar,et al.  A novel dietary flavonoid fisetin inhibits androgen receptor signaling and tumor growth in athymic nude mice. , 2008, Cancer research.

[15]  H. Mukhtar,et al.  Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cells. , 2008, Carcinogenesis.

[16]  P. Clarys,et al.  Estimation of daily human intake of food flavonoids , 2008, International journal of food sciences and nutrition.

[17]  L. Klotz,et al.  Novel antiproliferative flavonoids induce cell cycle arrest in human prostate cancer cell lines , 2006, Prostate Cancer and Prostatic Diseases.

[18]  J. Arunakaran,et al.  Quercetin-induced growth inhibition and cell death in prostatic carcinoma cells (PC-3) are associated with increase in p21 and hypophosphorylated retinoblastoma proteins expression , 2005, Journal of Cancer Research and Clinical Oncology.

[19]  ダニエル エル. フリン,et al.  Anti-cancer agents , 2003 .

[20]  F. M. Dean,et al.  737. The course of the Algar–Flynn–Oyamada (A.F.O.) reaction , 1965 .