Caspase cleavage of the amyloid precursor protein is prevented after overexpression of bcl-2 in a triple transgenic mouse model of Alzheimer's disease.
暂无分享,去创建一个
E. Head | V. Galvan | T. Rohn | D. Kumasaka
[1] E. Head,et al. Lack of Pathology in a Triple Transgenic Mouse Model of Alzheimer's Disease after Overexpression of the Anti-Apoptotic Protein Bcl-2 , 2008, The Journal of Neuroscience.
[2] Phillip B. Jones,et al. In Vivo Imaging Reveals Dissociation between Caspase Activation and Acute Neuronal Death in Tangle-Bearing Neurons , 2008, The Journal of Neuroscience.
[3] N. Danial,et al. BCL-2 Family Proteins: Critical Checkpoints of Apoptotic Cell Death , 2007, Clinical Cancer Research.
[4] R. Tanzi,et al. Depletion of GGA3 Stabilizes BACE and Enhances β-Secretase Activity , 2007, Neuron.
[5] Li-chun Wei,et al. Fluoro-Jade C can specifically stain the degenerative neurons in the substantia nigra of the 1-methy-4-phenyl-1,2,3,6-tetrahydro pyrindine-treated C57BL/6 mice , 2007, Brain Research.
[6] D. Dickson,et al. Filling the Gaps in the Aβ Cascade Hypothesis of Alzheimers Disease , 2006 .
[7] C. Borner. Faculty Opinions recommendation of Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664. , 2006 .
[8] D. Bredesen,et al. Aβ induces cell death by direct interaction with its cognate extracellular domain on APP (APP 597–624) , 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[9] Kwang-Ho Ha,et al. Caspase-mediated cleavage of glial fibrillary acidic protein within degenerating astrocytes of the Alzheimer's disease brain. , 2006, The American journal of pathology.
[10] Valérie Wilquet,et al. Amyloid-beta precursor protein processing in neurodegeneration , 2004, Current Opinion in Neurobiology.
[11] C. Cotman,et al. Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. , 2004, The Journal of clinical investigation.
[12] C. Cotman,et al. Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and in Alzheimer's disease , 2003, Neurobiology of Disease.
[13] D. Bredesen,et al. Caspase cleavage of the amyloid precursor protein modulates amyloid β‐protein toxicity , 2003, Journal of neurochemistry.
[14] M. Mattson,et al. Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles Intracellular Aβ and Synaptic Dysfunction , 2003, Neuron.
[15] R. Berry,et al. Caspase cleavage of tau: Linking amyloid and neurofibrillary tangles in Alzheimer's disease , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[16] C. Cotman,et al. Caspase-9 Activation and Caspase Cleavage of tau in the Alzheimer's Disease Brain , 2002, Neurobiology of Disease.
[17] D. Bredesen,et al. Caspase cleavage of members of the amyloid precursor family of proteins , 2002, Journal of neurochemistry.
[18] C. Cotman,et al. Caspase-cleaved amyloid precursor protein and activated caspase-3 are co-localized in the granules of granulovacuolar degeneration in Alzheimer's disease and Down's syndrome brain , 2002, Acta Neuropathologica.
[19] S. Chandra,et al. A second cytotoxic proteolytic peptide derived from amyloid β-protein precursor , 2000, Nature Medicine.
[20] David Smith,et al. Involvement of Caspases in Proteolytic Cleavage of Alzheimer’s Amyloid-β Precursor Protein and Amyloidogenic Aβ Peptide Formation , 1999, Cell.
[21] Jean-Claude Martinou,et al. Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia , 1994, Neuron.
[22] G. Johnson,et al. The role of tau phosphorylation and cleavage in neuronal cell death. , 2007, Frontiers in bioscience : a journal and virtual library.
[23] R. Tanzi,et al. Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity. , 2007, Neuron.
[24] D. Dickson,et al. Filling the gaps in the abeta cascade hypothesis of Alzheimer's disease. , 2006, Current Alzheimer research.
[25] F. LaFerla,et al. A dynamic relationship between intracellular and extracellular pools of Abeta. , 2006, The American journal of pathology.
[26] S. Chandra,et al. A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor. , 2000, Nature medicine.
[27] G. Robertson,et al. Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation. , 1999, Cell.
[28] F. LaFerla,et al. Copyright © American Society for Investigative Pathology DOI: 10.2353/ajpath.2006.050593 Molecular Pathogenesis of Genetic and Inherited Diseases A Dynamic Relationship between Intracellular and Extracellular Pools of A� , 2022 .