Left-Handed Metamaterial-Inspired Unit Cell for S-Band Glucose Sensing Application

This paper presents an oval-shaped sensor design for the measurement of glucose concentration in aqueous solution. This unit cell sensing device is inspired by metamaterial properties and is analytically described for better parametric study. The mechanism of the sensor is a sensing layer with varying permittivity placed between two nozzle-shaped microstrip lines. Glucose aqueous solutions were characterized considering the water dielectric constant, from 55 to 87, and were identified with a transmission coefficient at 3.914 GHz optimal frequency with double negative (DNG) metamaterial properties. Consequently, the sensitivity of the sensor was estimated at 0.037 GHz/(30 mg/dL) glucose solution. The design and analysis of this sensor was performed using the finite integration technique (FIT)-based Computer Simulation Technology (CST) microwave studio simulation software. Additionally, parametric analysis of the sensing characteristics was conducted using experimental verification for the justification. The performance of the proposed sensor demonstrates the potential application scope for glucose level identification in aqueous solutions regarding qualitative analysis.

[1]  Kiejin Lee,et al.  Microwave dielectric resonator biosensor for aqueous glucose solution. , 2008, The Review of scientific instruments.

[2]  Nigel A. Surridge,et al.  The Technology Behind Glucose Meters: Test Strips , 2008 .

[3]  B. Kapilevich,et al.  Microwave sensor for accurate measurements of water solution concentrations , 2007, 2007 Asia-Pacific Microwave Conference.

[4]  Eun-Soo Kim,et al.  Rapid, Sensitive, and Reusable Detection of Glucose by a Robust Radiofrequency Integrated Passive Device Biosensor Chip , 2015, Scientific Reports.

[5]  P. Patel,et al.  An ENG resonator-based microwave sensor for the characterization of aqueous glucose , 2018 .

[6]  David Vrba,et al.  A Microwave Metamaterial Inspired Sensor for Non-Invasive Blood Glucose Monitoring , 2015 .

[7]  R. Weigel,et al.  A highly sensitive glucose biosensor based on a microstrip ring resonator , 2013, 2013 IEEE MTT-S International Microwave Workshop Series on RF and Wireless Technologies for Biomedical and Healthcare Applications (IMWS-BIO).

[8]  Shekhar Bhansali,et al.  Recent advances in metamaterial split-ring-resonator circuits as biosensors and therapeutic agents. , 2016, Biosensors & bioelectronics.

[9]  David Dubuc,et al.  Microwave-Based Microfluidic Sensor for Non-Destructive and Quantitative Glucose Monitoring in Aqueous Solution , 2016, Sensors.

[10]  D. Uttamchandani,et al.  A Microwave Dielectric Biosensor Based on Suspended Distributed MEMS Transmission Lines , 2009, IEEE Sensors Journal.

[11]  Alexander A. Barannik,et al.  High sensitivity microwave characterization of organic molecule solutions of nanoliter volume , 2009 .

[12]  S. Evans,et al.  Dielectric measurements with an open-ended coaxial probe , 1987 .

[13]  C. Navau,et al.  Enhancing the sensitivity of magnetic sensors by 3D metamaterial shells , 2017, Scientific Reports.

[14]  Mojgan Daneshmand,et al.  Highly sensitive microwave split ring resonator sensor using gap extension for glucose sensing , 2017, 2017 IEEE MTT-S International Microwave Workshop Series on Advanced Materials and Processes for RF and THz Applications (IMWS-AMP).

[15]  David Dubuc,et al.  Optimized electromagnetic interaction microwave resonator/microfluidic channel for enhanced liquid bio-sensor , 2013, 2013 European Microwave Conference.

[16]  A. Babajanyan,et al.  DETERMINATION OF GLUCOSE CONCENTRATION IN AQUEOUS SOLUTION BY USING MODIFIED HILBERT SHAPED MICROWAVE METAMATERIAL SENSOR , 2018, Proceedings of the YSU A: Physical and Mathematical Sciences.

[17]  F. E. Terman,et al.  Radio Engineers Handbook , 1943 .

[18]  I. Bahl.  Lumped Elements for RF and Microwave Circuits , 2003 .

[19]  S. Genuth,et al.  The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. , 1993, The New England journal of medicine.

[20]  Ming Huang,et al.  Double Negative Metamaterial Sensor Based on Microring Resonator , 2011, IEEE Sensors Journal.

[21]  M. P. Jayakrishnan,et al.  Microwave Based Biosensor for Blood Glucose Monitoring , 2015, 2015 Fifth International Conference on Advances in Computing and Communications (ICACC).

[22]  R. Weigel,et al.  Determination of sugar concentration in aqueous solutions using ultra-wideband microwave impedance spectroscopy , 2013, 2013 IEEE MTT-S International Microwave Symposium Digest (MTT).

[23]  R. N. Clarke,et al.  A guide to the characterisation of dielectric materials at RF and microwave frequencies. , 2003 .

[24]  G. Palai,et al.  Realization of accurate blood glucose sensor using photonics based metamaterial , 2018, Optik.

[25]  Nam-Young Kim,et al.  Complex permittivity characterization of serum with an air-bridge enhanced capacitor for quantifiable detection of glucose , 2015 .

[26]  Mohammad Tariqul Islam,et al.  A New Direct Retrieval Method of Refractive Index for the Metamaterial , 2015 .

[27]  Yuanjin Zheng,et al.  Noninvasive Glucose Measurement by Microwave Biosensor with Accuracy Enhancement , 2018, 2018 IEEE International Symposium on Circuits and Systems (ISCAS).

[28]  F. Soldovieri,et al.  A Microwave Resonant Sensor for Concentration Measurements of Liquid Solutions , 2013, IEEE Sensors Journal.