PAT-tools for process control in pharmaceutical film coating applications.

[1]  J P Kennedy,et al.  Preliminary assessment of an image analysis method for the evaluation of pharmaceutical coatings. , 1997, Pharmaceutical development and technology.

[2]  K. Wahlund,et al.  Monitoring of a film coating process for tablets using near infrared reflectance spectrometry. , 1999, Journal of pharmaceutical and biomedical analysis.

[3]  J. Gottfries,et al.  Quantitative analysis of film coating in a fluidized bed process by in-line NIR spectrometry and multivariate batch calibration. , 2000, Analytical chemistry.

[4]  Poul Bertelsen,et al.  Validation of an image analysis method for estimating coating thickness on pellets. , 2003, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[5]  B. Buchanan,et al.  Use of Near-Infrared Spectroscopy to Evaluate an Active in a Film Coated Tablet , 1996, Pharmaceutical Research.

[6]  Joseph B. Schwartz,et al.  Particle Size Distributions of Inert Spheres and Pelletized Pharmaceutical Products by Image Analysis , 2005, Pharmaceutical development and technology.

[7]  J. Drennen,et al.  Near-Infrared Spectroscopic Monitoring of the Film Coating Process , 1996, Pharmaceutical Research.

[8]  P. Taday,et al.  Nondestructive analysis of tablet coating thicknesses using terahertz pulsed imaging. , 2005, Journal of pharmaceutical sciences.

[9]  Edward R Grant,et al.  Raman spectroscopic measurement of tablet-to-tablet coating variability. , 2005, Journal of pharmaceutical and biomedical analysis.

[10]  Gabriele Reich,et al.  Near-infrared spectroscopy and imaging: basic principles and pharmaceutical applications. , 2005, Advanced drug delivery reviews.

[11]  K. Morris,et al.  Raman spectroscopy for tablet coating thickness quantification and coating characterization in the presence of strong fluorescent interference. , 2006, Journal of pharmaceutical and biomedical analysis.

[12]  Hoeil Chung,et al.  New reliable Raman collection system using the wide area illumination (WAI) scheme combined with the synchronous intensity correction standard for the analysis of pharmaceutical tablets. , 2006, Analytica chimica acta.

[13]  San Kiang,et al.  Raman spectroscopy for the determination of coating uniformity of tablets: assessment of product quality and coating pan mixing efficiency during scale-up , 2007, Journal of Pharmaceutical Innovation.

[14]  J. Kauffman,et al.  Raman spectroscopy of coated pharmaceutical tablets and physical models for multivariate calibration to tablet coating thickness. , 2007, Journal of pharmaceutical and biomedical analysis.

[15]  Yaochun Shen,et al.  Comparison of Terahertz Pulse Imaging and Near-Infrared Spectroscopy for Rapid, Non-Destructive Analysis of Tablet Coating Thickness and Uniformity , 2007, Journal of Pharmaceutical Innovation.

[16]  D. Massart,et al.  Near-infrared spectroscopy applications in pharmaceutical analysis. , 2007, Talanta.

[17]  J. Rantanen,et al.  Raman spectroscopy for quantitative analysis of pharmaceutical solids , 2007, The Journal of pharmacy and pharmacology.

[18]  Yaochun Shen,et al.  Analysis of coating structures and interfaces in solid oral dosage forms by three dimensional terahertz pulsed imaging. , 2007, Journal of pharmaceutical sciences.

[19]  M Pepper,et al.  Analysis of sustained-release tablet film coats using terahertz pulsed imaging. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[20]  Yaochun Shen,et al.  Delayed release tablet dissolution related to coating thickness by terahertz pulsed image mapping. , 2008, Journal of pharmaceutical sciences.

[21]  Niklas Sandler,et al.  Prediction of Tablet Film-coating Thickness Using a Rotating Plate Coating System and NIR Spectroscopy , 2008, AAPS PharmSciTech.

[22]  Kenneth R. Morris,et al.  Quantitative analysis of film coating in a pan coater based on in-line sensor measurements , 2005, AAPS PharmSciTech.

[23]  H. Frijlink,et al.  Quantitative Image Analysis for Evaluating the Coating Thickness and Pore Distribution in Coated Small Particles , 2009, Pharmaceutical Research.

[24]  Stephen W Hoag,et al.  Quality by design, part II: application of NIR spectroscopy to monitor the coating process for a pharmaceutical sustained release product. , 2008, Journal of pharmaceutical sciences.

[25]  Henderik W Frijlink,et al.  Application of process analytical technology in tablet process development using NIR spectroscopy: blend uniformity, content uniformity and coating thickness measurements. , 2008, International journal of pharmaceutics.

[26]  Yaochun Shen,et al.  Effects of film coating thickness and drug layer uniformity on in vitro drug release from sustained-release coated pellets: a case study using terahertz pulsed imaging. , 2009, International journal of pharmaceutics.

[27]  Hans Leuenberger,et al.  Terahertz pulsed imaging and near infrared imaging to monitor the coating process of pharmaceutical tablets. , 2009, International journal of pharmaceutics.

[28]  Young-Sang Cho,et al.  Dynamic calibration for the in-line NIR monitoring of film thickness of pharmaceutical tablets processed in a fluid-bed coater. , 2010, Journal of pharmaceutical sciences.

[29]  Peter Kleinebudde,et al.  Validation of Raman spectroscopic procedures in agreement with ICH guideline Q2 with considering the transfer to real time monitoring of an active coating process. , 2010, Journal of pharmaceutical and biomedical analysis.

[30]  Peter Kleinebudde,et al.  Feasibility of Raman spectroscopy as PAT tool in active coating , 2009, Drug development and industrial pharmacy.

[31]  Bostjan Likar,et al.  Digital imaging as a process analytical technology tool for fluid-bed pellet coating process. , 2010, European Journal of Pharmaceutical Sciences.

[32]  Kim H. Esbensen,et al.  Monitoring of pellet coating process with image analysis—a feasibility study , 2010 .

[33]  Robert Gurny,et al.  Terahertz pulsed imaging, a novel process analytical tool to investigate the coating characteristics of push-pull osmotic systems. , 2010, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[34]  L. Chan,et al.  Comparative study of non-destructive methods to quantify thickness of tablet coatings. , 2010, International journal of pharmaceutics.

[35]  M. Melichar,et al.  In‐line analysis of a fluid bed pellet coating process using a combination of near infrared and Raman spectroscopy , 2010 .

[36]  Klára Pintye-Hódi,et al.  From Mini to Micro Scale—Feasibility of Raman Spectroscopy as a Process Analytical Tool (PAT) , 2011, Pharmaceutics.

[37]  Min-Jeong Lee,et al.  In line NIR quantification of film thickness on pharmaceutical pellets during a fluid bed coating process. , 2011, International journal of pharmaceutics.

[38]  Shuncong Zhong,et al.  Terahertz in-line sensor for direct coating thickness measurement of individual tablets during film coating in real-time. , 2011, Journal of pharmaceutical sciences.

[39]  Pierre Chaminade,et al.  Real-time predictions of drug release and end point detection of a coating operation by in-line near infrared measurements. , 2011, International journal of pharmaceutics.

[40]  C Vervaet,et al.  Near infrared and Raman spectroscopy for the in-process monitoring of pharmaceutical production processes. , 2011, International journal of pharmaceutics.

[41]  Michel Baron,et al.  Development of a Process Analytical Technology (PAT) for in-line monitoring of film thickness and mass of coating materials during a pan coating operation. , 2011, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[42]  Peter Kleinebudde,et al.  Validation of Terahertz coating thickness measurements using X-ray microtomography. , 2012, Molecular pharmaceutics.

[43]  P Kleinebudde,et al.  A comparison of quality control methods for active coating processes. , 2012, International journal of pharmaceutics.

[44]  Peter Kleinebudde,et al.  Prediction of dissolution time and coating thickness of sustained release formulations using Raman spectroscopy and terahertz pulsed imaging. , 2012, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[45]  T Puchert,et al.  A novel in-line NIR spectroscopy application for the monitoring of tablet film coating in an industrial scale process. , 2012, Talanta.

[46]  P Kleinebudde,et al.  Development and in-line validation of a Process Analytical Technology to facilitate the scale up of coating processes. , 2013, Journal of pharmaceutical and biomedical analysis.