Lithium Ion-selective Electrodes Employing Tetrahydrofuran-based 16-Crown-4 Derivatives as Neutral Carriers

The potentiometric response characteristics of lithium ion-selective membrane electrodes employing three different THF-type 16-crown-4 derivatives as ionophores were investigated. Of the THF- based crown compounds tested, a cis-type isomer of the derivative with only methyl groups (H/CH3) at four bridged positions (cis-THF-I) was found to exhibit the best selectivity for Li+ over other cations. The composition of the cis-THF-I-based PVC-matrix membrane was optimized and its performance was compared with those based on lithium ionophores reported previously. The new cis-THF-I-based membrane exhibits remarkably enhanced selectivities for lithium over other cations: logKpotLi,Na = –2.8, logKpotLi,K = –4.6, logKpotLi,NH4 = –5.4, logKpotLi,Ca = –5.7 and logKpotLi,Mg = –5.4. Furthermore, it was found that serum components do not interfere significantly with the lithium measurements when the cis-THF-I-based electrode is used. The response of the electrode was found to be linear in the clinical range of interest.

[1]  George F. Wright,et al.  THE CONDENSATION OF METHYL KETONES WITH FURAN , 1955 .

[2]  M. Asada,et al.  Macrocyclic ligands composed of tetrahydrofuran for selective transport of monovalent cations through liquid membranes , 1976 .

[3]  D. Tosteson.  Lithium and mania. , 1981, Scientific American.

[4]  A. F. Zhukov,et al.  Lipophilic Diamides as Ionophores for Alkali and Alkaline Earth Metal Cations , 1982 .

[5]  G. Christian,et al.  Determination of selectivity coefficients of ion-selective electrodes by a matched-potential method , 1984 .

[6]  B. Kräutler,et al.  A Lipophilic Derivative of Vitamin B12 as Selective Carrier for Anions , 1984 .

[7]  R. Ng,et al.  The Technicon RA-1000 evaluated for measuring sodium, potassium, chloride, and carbon dioxide. , 1985, Clinical chemistry.

[8]  M. Egli,et al.  3,7-Dioxaazelaamides as Ionophores for Lithium Ion Selective Liquid Membrane Electrodes , 1986 .

[9]  W. Simon,et al.  Ion-selective membrane electrodes for clinical use. , 1986, Clinical chemistry.

[10]  W. Simon,et al.  Ion selective liquid membrane electrode for the assay of lithium in blood serum. , 1986, Analytical chemistry.

[11]  W. Simon,et al.  Lithium/sodium ion concentration ratio measurements in blood serum with lithium and sodium ion selective liquid membrane electrodes. , 1987, Analytical chemistry.

[12]  K. Kimura,et al.  Lithium ion selective electrodes based on crown ethers for serum lithium assay. , 1987, Analytical chemistry.

[13]  G. Christian,et al.  Comparative evaluation of neutral, and proton-ionizable crown ether compounds as lithium ionophores in ion-selective electrodes and in solvent extraction , 1988 .

[14]  W. Simon,et al.  Elimination of the asymmetry in neutral-carrier-based solvent polymeric membranes induced by proteins. , 1988, Analytical chemistry.

[15]  M. Meyerhoff.  New in vitro analytical approaches for clinical chemistry measurements in critical care. , 1990, Clinical chemistry.

[16]  K. Tohda,et al.  Design and synthesis of lithium ionophores for an ion-selective electrode by chemical modification of natural carboxylic polyether antibiotic monensin , 1990 .

[17]  W. E. Morf,et al.  Selectivity-modifying influence of anionic sites in neutral-carrier-based membrane electrodes , 1991 .

[18]  R. Kataky,et al.  Comparative performance of 14-crown-4 derivatives as lithium-selective electrodes. , 1991, The Analyst.

[19]  Yu Liu,et al.  Molecular design of crown ethers. 12. Complexation thermodynamics of 12- to 16-crown-4: thermodynamic origin of high lithium selectivity of 14-crown-4 , 1993 .

[20]  Koji Suzuki,et al.  Design and synthesis of highly selective ionophores for lithium ion based on 14-crown-4 derivatives for an ion-selective electrode , 1993 .

[21]  Lipophilic Crown-4 Derivatives as Lithium Ionophores for Lithium Ion Selective Liquid Membrane Electrodes , 1993 .

[22]  Takayuki Inoue,et al.  Amine-armed aza-12-crown-4 as a new Li+ ion-specific ionophore , 1993 .

[23]  R. Yatscoff,et al.  Evaluation of the i-STAT system: a portable chemistry analyzer for the measurement of sodium, potassium, chloride, urea, glucose, and hematocrit. , 1995, Clinical biochemistry.

[24]  Evaluation of the ion selective electrodes module in the DAX analyzers , 1995 .

[25]  Minimization of Asymmetry Potential in ETH 129-Based Calcium-Selective Membrane Electrodes , 1995 .

[26]  T. Okada,et al.  Role of plasticizers on the characteristics of poly(vinyl chloride)-membrane lithium-selective electrodes based on phenanthroline derivatives , 1995 .

[27]  Lithium Ion-Selective Electrode Based on THF-Based 16-Crown-4 Derivatives , 1995 .

[28]  Linearity and stability of the AVL and Nova magnesium and calcium ion-selective electrodes. , 1996, Clinical chemistry.