A PILOT STUDY OF NORMATIVE DATA FOR MACULAR THICKNESS AND VOLUME MEASUREMENTS USING CIRRUS HIGH-DEFINITION OPTICAL COHERENCE TOMOGRAPHY

Purpose: To establish preliminary normative data for macular thickness (MT) and macular volume (MV) by Cirrus high-definition optical coherence tomography (Carl Zeiss Meditec, Dublin, CA). Methods: Retrospective case series of 192 eyes of 192 subjects (age, 20–90 years) without retinal disease or surgery with best-corrected visual acuity ≥20/25, intraocular pressure <21 mmHg, and cup-to-disc ratio ≤0.5 were enrolled. Retinal thicknesses in nine Early Treatment Diabetic Retinopathy Study subfields (including central subfield thickness [CST]), MT, and MV were measured with Cirrus high-definition optical coherence tomography. Effects of age, gender, lens status, and diabetic status on these measurements were analyzed. Results: The mean ±SD CST, MT, and MV were 262.4 ± 22.8 μm, 281.3 ± 14.5 μm, and 10.1 ± 0.6 mm3, respectively. Although CST and age were not associated (P = 0.45), both mean MT and mean MV declined with age (P < 0.0001). Central subfield thickness (P = 0.002), mean MT (P = 0.021), and MV (P = 0.041) were higher in men compared with women. Neither lens status nor diabetic status affected CST, MT, or MV. Conclusion: A pilot study showed that preliminary normative CST, MT, and MV values were obtained by Cirrus high-definition optical coherence tomography. The authors propose that CST ranges from 216.8 μm to 308 μm in normal eyes. Older age and female gender were associated with thinner MT.