More frequent partner hugs and higher oxytocin levels are linked to lower blood pressure and heart rate in premenopausal women

In animals, ventral stroking for >5 days increases oxytocin (OT) activity and decreases blood pressure (BP), but related human studies are few. Thus, relationships between self-reported frequency of partner hugs, plasma OT and BP levels were examined in 59 premenopausal women before and after warm contact with their husbands/partners ending with hugs. Higher baseline OT before partner contact was associated with lower BP and heart rate, and met criteria to be a partial mediator of the lower resting BP shown by women reporting more frequent hugs (P<0.05). OT levels during post-contact stress were unrelated to hugs or BP. Menstrual cycle phase did not influence any OT measure. Thus, frequent hugs between spouses/partners are associated with lower BP and higher OT levels in premenopausal women; OT-mediated reduction in central adrenergic activity and peripheral effects of OT on the heart and vasculature are pathways to examine in future research.

[1]  M. Altemus,et al.  Increased vasopressin and adrenocorticotropin responses to stress in the midluteal phase of the menstrual cycle. , 2001, The Journal of clinical endocrinology and metabolism.

[2]  M. Altemus,et al.  Chapter 17 Neuroendocrine and emotional changes in the post-partum period , 2001 .

[3]  L. Diamond.  Passionate Friendships Among Adolescent Sexual-Minority Women , 2000 .

[4]  D. Pfaff,et al.  An estrogen-dependent four-gene micronet regulating social recognition: a study with oxytocin and estrogen receptor-alpha and -beta knockout mice. , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[5]  A. Sherwood,et al.  Blood Pressure Reactivity and Marital Distress in Employed Women , 1998, Psychosomatic medicine.

[6]  M. Boccia,et al.  Deficits in plasma oxytocin responses and increased negative affect, stress, and blood pressure in mothers with cocaine exposure during pregnancy. , 2004, Addictive behaviors.

[7]  Christopher A. Moyer,et al.  A meta-analysis of massage therapy research. , 2004, Psychological bulletin.

[8]  J. Szalai,et al.  Marital support, spousal contact and the course of mild hypertension. , 2003, Journal of psychosomatic research.

[9]  K. Light,et al.  Warm Partner Contact Is Related to Lower Cardiovascular Reactivity , 2003, Behavioral medicine.

[10]  High blood pressure and marital discord: not being nasty matters more than being nice. , 1991, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[11]  K. Light,et al.  Hostility, conflict and cardiovascular responses in married couples: a focus on the dyad , 2005, International journal of behavioral medicine.

[12]  C. Carter,et al.  Oxytocin and sexual behavior , 1992, Neuroscience & Biobehavioral Reviews.

[13]  K. Uvnäs‐Moberg,et al.  OXYTOCIN MAY MEDIATE THE BENEFITS OF POSITIVE SOCIAL INTERACTION AND EMOTIONS 1 The purpose of this paper is to describe the neuroendocrine mechanisms of positive social interactions. 1 , 1998, Psychoneuroendocrinology.

[14]  J. Odendaal,et al.  Neurophysiological correlates of affiliative behaviour between humans and dogs. , 2003, Veterinary journal.

[15]  H. Kraemer,et al.  High blood pressure and marital discord: not being nasty matters more than being nice. , 1991, Health Psychology.

[16]  K. Uvnäs‐Moberg,et al.  Postnatal oxytocin treatment and postnatal stroking of rats reduce blood pressure in adulthood , 2002, Autonomic Neuroscience.

[17]  T. Lundeberg,et al.  Oxytocin Causes a Long-Term Decrease of Blood Pressure in Female and Male Rats , 1996, Physiology & Behavior.

[18]  D. M. Lyons,et al.  Effects of Emotion on Oxytocin, Prolactin, and ACTH in Women , 2002, Stress.

[19]  J. Amico,et al.  An oxytocin precursor intermediate circulates in the plasma of humans and rhesus monkeys administered estrogen. , 1990, Neuroendocrinology.

[20]  R. Cardinal,et al.  Negative Inotropic and Chronotropic Effects of Oxytocin , 2001, Hypertension.

[21]  L. Nolan,et al.  Biological psychology , 2019, An Introduction to the Psychology of Humor.

[22]  C. Notarius,et al.  Marital research in the 20th century and a research agenda for the 21st century. , 2002, Family process.

[23]  K. Light,et al.  Relationship quality: effects on ambulatory blood pressure and negative affect in a biracial sample of men and women , 2005, Blood pressure monitoring.

[24]  S. Seif,et al.  Oxytocin in human plasma: correlation with neurophysin and stimulation with estrogen. , 1981, The Journal of clinical endocrinology and metabolism.

[25]  M. Altemus,et al.  Preliminary research on plasma oxytocin in normal cycling women: investigating emotion and interpersonal distress. , 1999, Psychiatry.

[26]  L. Berkman.  The role of social relations in health promotion. , 1995, Psychosomatic medicine.

[27]  J. Johns,et al.  Acute cocaine alters oxytocin levels in the medial preoptic area and amygdala in lactating rat dams: implications for cocaine-induced changes in maternal behavior and maternal aggression , 2001, Neuropeptides.

[28]  K. Light,et al.  Oxytocin responsivity in mothers of infants: a preliminary study of relationships with blood pressure during laboratory stress and normal ambulatory activity. , 2000, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[29]  M. Forsling,et al.  Osmotically‐induced release of vasopressin and oxytocin in non‐pregnant women ‐ influence of estrogen and progesterone , 1998, Acta obstetricia et gynecologica Scandinavica.

[30]  J. Cacioppo,et al.  The relationship between social support and physiological processes: a review with emphasis on underlying mechanisms and implications for health. , 1996, Psychological bulletin.

[31]  M. McCarthy,et al.  An ovarian steroid hormone regimen that increases hypothalamic oxytocin expression alters [ 3 H ] muscimol binding in the hypothalamic supraoptic nucleus of the female rat , 2000, Brain Research.

[32]  J. Kiecolt-Glaser,et al.  Marriage and health: his and hers. , 2001, Psychological bulletin.

[33]  S. Porges,et al.  Responses to Laboratory Psychosocial Stress in Postpartum Women , 2001, Psychosomatic medicine.

[34]  T. Insel,et al.  The neurobiology of attachment , 2001, Nature Reviews Neuroscience.

[35]  M. Petersson.  Cardiovascular effects of oxytocin. , 2002, Progress in brain research.

[36]  M. Åkerlund,et al.  Oxytocin mRNA content in the endometrium of non‐pregnant women , 2004, BJOG : an international journal of obstetrics and gynaecology.

[37]  K. Light,et al.  Family support and cardiovascular responses in married couples during conflict and other interactions , 1999, International journal of behavioral medicine.

[38]  Carol Carter Porges.  Neuroendocrine perspectives on social attachment and love , 1998 .

[39]  S. Mccann,et al.  Oxytocin is a cardiovascular hormone. , 2000, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

[40]  T. Insel,et al.  Oxytocin Administered Centrally Facilitates Formation of a Partner Preference in Female Prairie Voles (Microtus ochrogaster) , 1994, Journal of neuroendocrinology.

[41]  Oxytocin responsivity in mothers of infants: a preliminary study of relationships with blood pressure during laboratory stress and normal ambulatory activity. , 2000, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[42]  S. Lightman,et al.  Psychological stress of exposure to uncontrollable noise increases plasma oxytocin in high emotionality women , 1990, Psychoneuroendocrinology.

[43]  Z. Csaba,et al.  Cellular biology of somatostatin receptors , 2001, Neuropeptides.

[44]  M. Altemus,et al.  Neuroendocrine and emotional changes in the post-partum period. , 2000, Progress in brain research.

[45]  T. Kamarck,et al.  Partner Interactions Are Associated With Reduced Blood Pressure in the Natural Environment: Ambulatory Monitoring Evidence From a Healthy, Multiethnic Adult Sample , 2001, Psychosomatic medicine.

[46]  Thomas R. Insel,et al.  The Neuroendocrine Basis of Social Recognition , 2002, Frontiers in Neuroendocrinology.

[47]  J. Cacioppo,et al.  Age-related changes in cardiovascular response as a function of a chronic stressor and social support. , 1992, Journal of personality and social psychology.

[48]  T. Insel,et al.  Increased accumulation of oxytocin messenger ribonucleic acid in the hypothalamus of the female rat: induction by long term estradiol and progesterone administration and subsequent progesterone withdrawal. , 1995, Endocrinology.

[49]  S. Kasl,et al.  Types of Marital Closeness and Mortality Risk in Older Couples , 2002, Psychosomatic medicine.

[50]  K. Fuxe,et al.  Systemic oxytocin treatment modulates α2-adrenoceptors in telencephalic and diencephalic regions of the rat , 2000, Brain Research.

[51]  I. Weaver,et al.  Natural variations in maternal care are associated with estrogen receptor alpha expression and estrogen sensitivity in the medial preoptic area. , 2003, Endocrinology.

[52]  T. Lundeberg,et al.  Short-term increase and long-term decrease of blood pressure in response to oxytocin-potentiating effect of female steroid hormones. , 1999, Journal of cardiovascular pharmacology.

[53]  T. Insel,et al.  Infant Vocalization, Adult Aggression, and Fear Behavior of an Oxytocin Null Mutant Mouse , 2000, Hormones and Behavior.

[54]  C. Pedersen,et al.  Oxytocin Control of Maternal Behavior Regulation by Sex Steroids and Offspring Stimuli a , 1997, Annals of the New York Academy of Sciences.

[55]  M. Forsling,et al.  Circulating oxytocin and vasopressin is influenced by ovarian steroid replacement in women , 1995, Acta obstetricia et gynecologica Scandinavica.

[56]  C. Nordin,et al.  TACTILE STIMULUS AND NEUROHORMONAL RESPONSE: A PILOT STUDY , 2003, The International journal of neuroscience.

[57]  Jim Blascovich,et al.  Cardiovascular Reactivity and the Presence of Pets, Friends, and Spouses: The Truth About Cats and Dogs , 2002, Psychosomatic medicine.

[58]  K. Light,et al.  Effects of Partner Support on Resting Oxytocin, Cortisol, Norepinephrine, and Blood Pressure Before and After Warm Partner Contact , 2005, Psychosomatic medicine.

[59]  C. Carter,et al.  Developmental exposure to oxytocin facilitates partner preferences in male prairie voles (Microtus ochrogaster). , 2003, Behavioral neuroscience.

[60]  E. Tribollet,et al.  Vasopressin and oxytocin receptors in the central nervous system. , 1996, Critical reviews in neurobiology.

[61]  D. Pfaff,et al.  An estrogen-dependent four-gene micronet regulating social recognition: A study with oxytocin and estrogen receptor-α and -β knockout mice , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[62]  K. Light,et al.  Oxytocinergic activity is linked to lower blood pressure and vascular resistance during stress in postmenopausal women on estrogen replacement , 2005, Hormones and Behavior.

[63]  R. Vollmer,et al.  Female oxytocin-deficient mice display enhanced anxiety-related behavior. , 2003, Endocrinology.

[64]  B. Burleson,et al.  Cardiovascular Reactivity and Initiate/Avoid Patterns of Marital Communication: A Test of Gottman's Psychophysiologic Model of Marital Interaction , 2001, Journal of Behavioral Medicine.

[65]  Magnus Lekman,et al.  THIS ARTICLE HAS BEEN RETRACTED 
Repeated massage‐like stimulation induces long‐term effects on nociception – contribution of oxytocinergic mechanisms , 2005, The European journal of neuroscience.

[66]  S. Knox,et al.  SOCIAL ISOLATION AND CARDIOVASCULAR DISEASE: AN ATHEROSCLEROTIC PATHWAY? , 1998, Psychoneuroendocrinology.

[67]  L. Cubeddu,et al.  Evaluation of a new ambulatory blood pressure monitor (Accutracker 102): laboratory comparisons with direct arterial pressure, stethoscopic auscultatory pressure, and readings from a similar monitor (Spacelabs Model 5200). , 1988, Psychophysiology.

[68]  S. Mccann,et al.  Oxytocin and its receptors are synthesized in the rat vasculature. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[69]  M. Boccia,et al.  Oxytocin Links Mothering Received, Mothering Bestowed and Adult Stress Responses , 2002, Stress.

[70]  Timothy W. Smith,et al.  Social relationships and ambulatory blood pressure: structural and qualitative predictors of cardiovascular function during everyday social interactions. , 2003, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[71]  D. A. Kenny,et al.  The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. , 1986, Journal of personality and social psychology.