The current treatment of erectile dysfunction

Erectile dysfunction (ED) is the inability to achieve and maintain an erection sufficient for satisfactory sexual intercourse. It is the most frequent sexual dysfunction in elderly men and its prevalence increases with age. Ever since ED was recognized as a real health problem, several treatment options became available and some of them proved to be very efficient. PDE5 inhibitors are the mainstay treatment of ED. However, other treatment options such as intracorporal injections, surgery, vacuum devices and prosthesis are also available for patients who are unresponsive to PDE5 inhibitors. Since none of the treatment options available so far has proven ideal, research in the field of sexual medicine continues. The aim of this paper is to review the most advances in the treatment of ED.

[1]  Garima,et al.  Psychosexual disorders and dermatologists , 2016, Indian dermatology online journal.

[2]  T. Karadeniz,et al.  Outcome of penile prosthesis implantation: are malleable prostheses an appropriate treatment option in patients with erectile dysfunction caused by prior radical surgery? , 2016, Asian journal of andrology.

[3]  R. Shabsigh,et al.  REVITALISE: A Large Observational Study Assessing the Safety and Effectiveness of Vardenafil in Men With Erectile Dysfunction and Metabolic Syndrome , 2016, Sexual medicine.

[4]  Abhishek P. Patel,et al.  The devil is in the details: an analysis of the subtleties between phosphodiesterase inhibitors for erectile dysfunction , 2016, Translational andrology and urology.

[5]  M. Hehemann,et al.  Can lifestyle modification affect men’s erectile function? , 2016, Translational andrology and urology.

[6]  A. Natali,et al.  Patient's satisfaction after 2-piece inflatable penile prosthesis implantation: An Italian multicentric study. , 2016, Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica.

[7]  K. Chiles.  Hypogonadism and erectile dysfunction as harbingers of systemic disease , 2016, Translational andrology and urology.

[8]  C. Carson,et al.  Testosterone deficiency in the aging male , 2016, Therapeutic advances in urology.

[9]  W. Brant,et al.  The treatment of erectile dysfunction in patients with neurogenic disease , 2016, Translational andrology and urology.

[10]  T. Lue,et al.  Normal male sexual function: emphasis on orgasm and ejaculation. , 2015, Fertility and sterility.

[11]  L. Vignozzi,et al.  Hypogonadism as a possible link between metabolic diseases and erectile dysfunction in aging men , 2015, Hormones.

[12]  S. Hill,et al.  A comparison of the available phosphodiesterase-5 inhibitors in the treatment of erectile dysfunction: a focus on avanafil , 2015, Patient preference and adherence.

[13]  Y. Ko,et al.  Long-term survival and patient satisfaction with inflatable penile prosthesis for the treatment of erectile dysfunction , 2015, Korean journal of urology.

[14]  A. Kadıoğlu,et al.  Tadalafil therapy for erectile dysfunction following prostatectomy , 2015, Therapeutic advances in urology.

[15]  F. Montorsi,et al.  Penile rehabilitation after radical prostatectomy: does it work? , 2015, Translational andrology and urology.

[16]  T. Lue,et al.  Prospects of stem cell treatment in benign urological diseases , 2015, Korean journal of urology.

[17]  B. Cuzin,et al.  Clinical Efficacy and Safety of Vitaros©/Virirec© (Alprostadil Cream) for the Treatment of Erectile Dysfunction , 2015, Urologia.

[18]  R. Sorrentino,et al.  Gas what: NO is not the only answer to sexual function , 2015, British journal of pharmacology.

[19]  J. Kim,et al.  Current status of penile rehabilitation after radical prostatectomy , 2015, Korean journal of urology.

[20]  Edward D. Kim,et al.  Endovascular treatment of vasculogenic erectile dysfunction , 2014, Asian journal of andrology.

[21]  D. Papagiannopoulos,et al.  Evaluation of young men with organic erectile dysfunction , 2014, Asian journal of andrology.

[22]  M. Cho,et al.  Udenafil for the treatment of erectile dysfunction , 2014, Therapeutics and clinical risk management.

[23]  J. Lee,et al.  Mirodenafil for the Treatment of Erectile Dysfunction: A Systematic Review of the Literature , 2014, The world journal of men's health.

[24]  P. De Fazio,et al.  Erectile Dysfunction in the Elderly: An Old Widespread Issue with Novel Treatment Perspectives , 2014, International journal of endocrinology.

[25]  Nan Li,et al.  Avanafil for male erectile dysfunction: a systematic review and meta-analysis , 2014, Asian journal of andrology.

[26]  Run Wang,et al.  New advances in erectile technology , 2014, Therapeutic advances in urology.

[27]  C. A. Koch,et al.  Transdermal testosterone replacement therapy in men , 2014, Drug design, development and therapy.

[28]  E. Farhadi,et al.  Evaluating the efficacy of vacuum constrictive device and causes of its failure in impotent patients. , 2014, Urology journal.

[29]  Wesley Ludwig,et al.  Organic Causes of Erectile Dysfunction in Men Under 40 , 2013, Urologia Internationalis.

[30]  T. Lue,et al.  Stem-cell therapy for erectile dysfunction , 2013, Arab journal of urology.

[31]  T. Vogl,et al.  Endovascular embolisation therapy in men with erectile impotence due to veno-occlusive dysfunction. , 2013, European journal of radiology.

[32]  I. Goldstein,et al.  Zotarolimus-eluting peripheral stents for the treatment of erectile dysfunction in subjects with suboptimal response to phosphodiesterase-5 inhibitors. , 2012, Journal of the American College of Cardiology.

[33]  A. Conti,et al.  Erectile rehabilitation with intracavernous alprostadil after radical prostatectomy: refusal and dropout rates , 2012, BJU international.

[34]  Kwangsung Park,et al.  What do most erectile dysfunction guidelines have in common? No evidence-based discussion or recommendation of heart-healthy lifestyle changes and/or Panax ginseng. , 2012, Asian journal of andrology.

[35]  G. Lin,et al.  Stem cell therapy for erectile dysfunction: a critical review. , 2012, Stem cells and development.

[36]  K. Andersson.  Mechanisms of Penile Erection and Basis for Pharmacological Treatment of Erectile Dysfunction , 2011, Pharmacological Reviews.

[37]  M. Murad,et al.  The effect of lifestyle modification and cardiovascular risk factor reduction on erectile dysfunction: a systematic review and meta-analysis. , 2011, Archives of internal medicine.

[38]  Francesco Montorsi,et al.  Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation. , 2010, European urology.

[39]  J. Yeager,et al.  Long-term, multicenter study of the safety and efficacy of topical alprostadil cream in male patients with erectile dysfunction. , 2009, The journal of sexual medicine.

[40]  S. Resim,et al.  The etiology of erectile dysfunction and contributing factors in different age groups in Turkey , 2004, International journal of urology : official journal of the Japanese Urological Association.

[41]  B. Olivier,et al.  Selective serotonin reuptake inhibitor‐induced sexual dysfunction: clinical and research considerations , 1998, International clinical psychopharmacology.