Case Report Pediatric Peritoneal Epithelial Malignant Mesothelioma Case Report

We present a 14-year-old boy with peritoneal epithelial malignant mesothelioma (PEMM). While pathology is required to make this diagnosis, radiology plays a crucial role throughout the clinical course of this disease. The key imaging characteristics of peritoneal mesothelioma have been previously well-described in the adult population, but there are rare reports in the pediatric population. This pediatric report highlights the multidimensional use of imaging in this disease, from the initial evaluation to therapeutic supplementation and subsequent follow-up.

[1]  I. Wistuba,et al.  Efficacy, Safety and Biomarker Analysis of Combined PD-L1 (Atezolizumab) and VEGF (Bevacizumab) Blockade in Advanced Malignant Peritoneal Mesothelioma. , 2021, Cancer discovery.

[2]  F. Galateau-Sallé,et al.  Mesothelioma in children and adolescents: the European Cooperative Study Group for Pediatric Rare Rumors (EXPeRT) contribution. , 2020, European journal of cancer.

[3]  F. Varlet,et al.  Multicystic and diffuse malignant peritoneal mesothelioma in children , 2020, Pediatric blood & cancer.

[4]  Ying-ying Gu,et al.  Role of p16 deletion and BAP1 loss in the diagnosis of malignant mesothelioma. , 2018, Journal of thoracic disease.

[5]  D. Labow,et al.  Malignant peritoneal mesothelioma: a review. , 2017, Annals of translational medicine.

[6]  K. Frazer,et al.  BAP1 mutation is a frequent somatic event in peritoneal malignant mesothelioma , 2015, Journal of Translational Medicine.

[7]  M. Hosoya,et al.  Malignant peritoneal mesothelioma in a child: chemotherapy with gemcitabine and platinum was effective for the disease unresponsive to other treatments. , 2014, Anti-cancer drugs.

[8]  N. Cox,et al.  Germline BAP1 mutations predispose to malignant mesothelioma , 2011, Nature Genetics.

[9]  Wengen Chen,et al.  The role of PET/CT in the management of peritoneal mesothelioma , 2011 .

[10]  R. Low,et al.  MR imaging of peritoneal disease: comparison of contrast-enhanced fast multiplanar spoiled gradient-recalled and spin-echo imaging. , 1994, AJR. American journal of roentgenology.

[11]  D. Brenner,et al.  CT of peritoneal mesothelioma: analysis of eight cases. , 1982, AJR. American journal of roentgenology.

[12]  H. Pass,et al.  Mesothelioma patients with germline BAP1 mutations have 7-fold improved long-term survival. , 2015, Carcinogenesis.

[13]  C. Paidas,et al.  Malignant peritoneal mesothelioma in a pediatric patient mimicking inflammatory bowel disease. , 2004, Digestive diseases and sciences.