The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors.
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Mithat Gönen | Tatiana Nikolskaya | Yuri Nikolsky | William C Hahn | David E Root | Kornelia Polyak | X Shirley Liu | Andriy Marusyk | Serena J Silver | W. Hahn | X. Liu | T. Nikolskaya | Y. Nikolsky | D. Root | A. Richardson | Jessica J. Kim | M. Gönen | K. Polyak | S. Silver | M. Gonen | K. Anderson | M. Shipitsin | N. Bloushtain-Qimron | R. Maruyama | S. Kim | S. Huh | A. Marusyk | V. Almendro | M. Bessarabova | S. Y. Park | D. Frank | H. Lee | Z. Wu | Reo Maruyama | Karen S Anderson | Jessica J Kim | So Young Kim | Andrea L Richardson | Noga Bloushtain-Qimron | Michail Shipitsin | So Yeon Park | Sarah R Walker | Vanessa Almendro | Hee Eun Lee | Zhenhua Wu | David A Frank | Sung Jin Huh | S. Choudhury | Lauren L C Marotta | Janina Schemme | Sibgat A Choudhury | Laura A Mulvey | Marina O Bessarabova | Laura P. A. Mulvey | So Young Kim | Janina Schemme | William C. Hahn | S. Walker | So Young Kim | X. Liu | Sibgat A. Choudhury | X. Liu | Noga Bloushtain-Qimron
[1] N. Nishimoto,et al. Anti-interleukin-6 receptor antibody therapy in rheumatic diseases. , 2006, Endocrine, metabolic & immune disorders drug targets.
[2] Howard Y. Chang,et al. Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[3] M. Gönen,et al. Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype. , 2010, The Journal of clinical investigation.
[4] Andrew J. Bannister,et al. LIF independent JAK signalling to chromatin in embryonic stem cells uncovered from an adult stem cell disease , 2010, Nature Cell Biology.
[5] Timothy C Wang,et al. Inflammation and cancer: IL-6 and STAT3 complete the link. , 2009, Cancer cell.
[6] Jeannette Bigler,et al. Non-steroidal anti-inflammatory drugs for cancer prevention: promise, perils and pharmacogenetics , 2006, Nature Reviews Cancer.
[7] Y. Durocher,et al. Glioblastoma-secreted factors induce IGFBP7 and angiogenesis by modulating Smad-2-dependent TGF-β signaling , 2008, Oncogene.
[8] M. Karin,et al. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. , 2009, Cancer cell.
[9] Wen-Lin Kuo,et al. A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. , 2006, Cancer cell.
[10] J. Phillips,et al. CXCR2 antagonists for the treatment of pulmonary disease. , 2009, Pharmacology & therapeutics.
[11] T. Rosol,et al. Fibroblasts isolated from common sites of breast cancer metastasis enhance cancer cell growth rates and invasiveness in an interleukin-6-dependent manner. , 2008, Cancer research.
[12] J. Dick,et al. Targeting of CD44 eradicates human acute myeloid leukemic stem cells , 2006, Nature Medicine.
[13] M. Götte,et al. Heparanase, hyaluronan, and CD44 in cancers: a breast carcinoma perspective. , 2006, Cancer research.
[14] S. Imbeaud,et al. Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours , 2009, Nature.
[15] W. Gerald,et al. Stat3 is tyrosine-phosphorylated through the interleukin-6/glycoprotein 130/Janus kinase pathway in breast cancer , 2007, Breast Cancer Research.
[16] Suyun Huang,et al. STAT3 as a central regulator of tumor metastases. , 2009, Current molecular medicine.
[17] W. Vainchenker,et al. JAKs in pathology: role of Janus kinases in hematopoietic malignancies and immunodeficiencies. , 2008, Seminars in cell & developmental biology.
[18] Jun Yao,et al. Regulation of in situ to invasive breast carcinoma transition. , 2008, Cancer cell.
[19] C. Maxwell,et al. Hyaluronan and hyaluronan synthases: potential therapeutic targets in cancer. , 2005, Current drug targets. Cardiovascular & haematological disorders.
[20] Li Li,et al. Autocrine-mediated Activation of STAT3 Correlates with Cell Proliferation in Breast Carcinoma Lines* , 2002, The Journal of Biological Chemistry.
[21] Stuart Gillies,et al. Menadione-induced Reactive Oxygen Species Generation via Redox Cycling Promotes Apoptosis of Murine Pancreatic Acinar Cells* , 2006, Journal of Biological Chemistry.
[22] J. Ritz,et al. B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues. , 1997, The Journal of clinical investigation.
[23] M. Ringnér,et al. The CD44+/CD24- phenotype is enriched in basal-like breast tumors , 2008, Breast Cancer Research.
[24] Kevin Struhl,et al. An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell Transformation , 2009, Cell.
[25] S. Morrison,et al. Prospective identification of tumorigenic breast cancer cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[26] A. Deblasio,et al. JAK2V617F-mediated phosphorylation of PRMT5 downregulates its methyltransferase activity and promotes myeloproliferation. , 2011, Cancer cell.
[27] Jeffrey M. Rosen,et al. Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features , 2009, Proceedings of the National Academy of Sciences.
[28] M. Frank,et al. The therapeutic promise of the cancer stem cell concept. , 2010, The Journal of clinical investigation.
[29] R. Beroukhim,et al. Molecular definition of breast tumor heterogeneity. , 2007, Cancer cell.
[30] Van,et al. A gene-expression signature as a predictor of survival in breast cancer. , 2002, The New England journal of medicine.
[31] Heike Knüpfer,et al. Significance of interleukin-6 (IL-6) in breast cancer (review) , 2007, Breast Cancer Research and Treatment.
[32] Angel Porgador,et al. Cell type-specific DNA methylation patterns in the human breast , 2008, Proceedings of the National Academy of Sciences.
[33] Y. Wong,et al. Prostacyclin receptor induces STAT1 and STAT3 phosphorylations in human erythroleukemia cells: a mechanism requiring PTX-insensitive G proteins, ERK and JNK. , 2006, Cellular signalling.
[34] V. Laporte,et al. Novel role of CXCR2 in regulation of gamma-secretase activity. , 2008, ACS chemical biology.
[35] D. Erdmann,et al. Potent and Selective Inhibition of Polycythemia by the Quinoxaline JAK2 Inhibitor NVP-BSK805 , 2010, Molecular Cancer Therapeutics.
[36] Kornelia Polyak,et al. Heterogeneity for Stem Cell–Related Markers According to Tumor Subtype and Histologic Stage in Breast Cancer , 2010, Clinical Cancer Research.
[37] Tatiana Nikolskaya,et al. Functional analysis of OMICs data and small molecule compounds in an integrated "knowledge-based" platform. , 2009, Methods in molecular biology.
[38] D. Santini,et al. IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland. , 2007, The Journal of clinical investigation.
[39] D. Birnbaum,et al. CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts. , 2010, The Journal of clinical investigation.
[40] M. Katsuki,et al. STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells , 1999, The EMBO journal.
[41] L. Bourguignon,et al. Hyaluronan-CD44 Interaction Activates Stem Cell Marker Nanog, Stat-3-mediated MDR1 Gene Expression, and Ankyrin-regulated Multidrug Efflux in Breast and Ovarian Tumor Cells* , 2008, Journal of Biological Chemistry.
[42] S. Vacher,et al. CXC chemokines located in the 4q21 region are up-regulated in breast cancer. , 2007, Endocrine-related cancer.
[43] J. Foekens,et al. Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer , 2005, The Lancet.
[44] P. Kuo,et al. Osteopontin: regulation in tumor metastasis , 2008, Cancer and Metastasis Reviews.
[45] Donna Spiegelman,et al. Aspirin intake and survival after breast cancer. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[46] K. Polyak,et al. Tumor heterogeneity: causes and consequences. , 2010, Biochimica et biophysica acta.
[47] F. Greten,et al. IKK/NF‐κB and STAT3 pathways: central signalling hubs in inflammation‐mediated tumour promotion and metastasis , 2009, EMBO reports.
[48] C. Maley,et al. Cancer is a disease of clonal evolution within the body1–3. This has profound clinical implications for neoplastic progression, cancer prevention and cancer therapy. Although the idea of cancer as an evolutionary problem , 2006 .
[49] Ozge Canli,et al. gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. , 2009, Cancer cell.
[50] N. Hacohen,et al. Highly parallel identification of essential genes in cancer cells , 2008, Proceedings of the National Academy of Sciences.
[51] Nir Hacohen,et al. Genome-scale loss-of-function screening with a lentiviral RNAi library , 2006, Nature Methods.
[52] M. Wicha. Targeting breast cancer stem cells. , 2009, Breast.
[53] A. Richardson,et al. Reciprocal Effects of STAT5 and STAT3 in Breast Cancer , 2009, Molecular Cancer Research.
[54] V. Ullrich,et al. Purification and characterization of recombinant human prostacyclin synthase. , 2004, Journal of biochemistry.
[55] Charles M. Perou,et al. Triple-Negative Breast Cancer: Risk Factors to Potential Targets , 2008, Clinical Cancer Research.
[56] John O Trent,et al. Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth , 2008, Molecular Cancer Therapeutics.
[57] Joshua F. McMichael,et al. Genome Remodeling in a Basal-like Breast Cancer Metastasis and Xenograft , 2010, Nature.
[58] Hua Yu,et al. The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors. , 2009, Cancer cell.
[59] Jeffrey M. Rosen,et al. The Increasing Complexity of the Cancer Stem Cell Paradigm , 2009, Science.
[60] Peter A Fasching,et al. The ubiquitin-like molecule interferon-stimulated gene 15 (ISG15) is a potential prognostic marker in human breast cancer , 2008, Breast Cancer Research.
[61] L. Zon,et al. Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis , 2007, Nature.
[62] Susan G Hilsenbeck,et al. Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy. , 2008, Journal of the National Cancer Institute.
[63] A. Pardanani. JAK2 inhibitor therapy in myeloproliferative disorders: rationale, preclinical studies and ongoing clinical trials , 2008, Leukemia.