Continuous growth of mean tumor diameter in a subset of grade II gliomas

Serial magnetic resonance images of 27 patients with untreated World Health Organization grade II oligodendrogliomas or mixed gliomas were reviewed retrospectively to study the kinetics of tumor growth before anaplastic transformation. Analysis of the mean tumor diameters over time showed constant growth. Linear regression, using a mixed model, found an average slope of 4.1mm per year (95% confidence interval, 3.8–4.4mm/year). Untreated low‐grade oligodendrogliomas or mixed gliomas grow continuously during their premalignant phase, and their pattern of growth can be predicted within a relatively narrow range. These findings could be of interest to optimize patients management and follow‐up. Ann Neurol 2003;53:524–528

[1]  R. Sattin.  Falls among older persons: a public health perspective. , 1992, Annual review of public health.

[2]  J. Murray,et al.  A mathematical model of glioma growth: the effect of extent of surgical resection , 1996, Cell proliferation.

[3]  M. Berger,et al.  The effect of extent of resection on recurrence in patients with low grade cerebral hemisphere gliomas , 1994, Cancer.

[4]  R. Makuch,et al.  Variations in the natural history and survival of patients with supratentorial low-grade astrocytomas. , 1996, Neurosurgery.

[5]  N. Teasdale,et al.  Attentional demands for postural control: the effects of aging and sensory reintegration. , 2001, Gait & posture.

[6]  J. Murray,et al.  A quantitative model for differential motility of gliomas in grey and white matter , 2000, Cell proliferation.

[7]  L. Deangelis,et al.  Long-term outcome of low-grade oligodendroglioma and mixed glioma , 2000, Neurology.

[8]  David R Grosshans,et al.  Aging and Surface Expression of Hippocampal NMDA Receptors* , 2002, The Journal of Biological Chemistry.

[9]  D. Madden,et al.  Functional neuroimaging of memory: Implications for cognitive aging , 2000, Microscopy research and technique.

[10]  P. Dutar,et al.  Alteration of NMDA receptor‐mediated synaptic responses in CA1 area of the aged rat hippocampus: Contribution of GABAergic and cholinergic deficits , 1998, Hippocampus.

[11]  G. Small,et al.  Predictors of cognitive change in middle-aged and older adults with memory loss. , 1995, The American journal of psychiatry.

[12]  R. Shadmehr,et al.  Mechanisms influencing acquisition and recall of motor memories. , 2002, Journal of neurophysiology.

[13]  P M Matthews,et al.  Evidence for adaptive functional changes in the cerebral cortex with axonal injury from multiple sclerosis. , 2000, Brain : a journal of neurology.

[14]  M. Hallett,et al.  Rapid plasticity of human cortical movement representation induced by practice. , 1998, Journal of neurophysiology.

[15]  M. Scerrati,et al.  Prognostic factors in low grade (WHO grade II) gliomas of the cerebral hemispheres: the role of surgery. , 1996, Journal of neurology, neurosurgery, and psychiatry.

[16]  L. Recht,et al.  Suspected low‐grade glioma: Is deferring treatment safe? , 1992, Annals of neurology.

[17]  R. Nudo,et al.  Role of adaptive plasticity in recovery of function after damage to motor cortex , 2001, Muscle & nerve.

[18]  C. Gerloff,et al.  The influence of normal aging on the cortical processing of a simple motor task , 2000, Neurology.

[19]  K. Fuxe,et al.  Cellular and synaptic alterations in the aging brain , 1990, Aging.

[20]  J. Murray,et al.  Virtual brain tumours (gliomas) enhance the reality of medical imaging and highlight inadequacies of current therapy , 2002, British Journal of Cancer.

[21]  M. D’Esposito,et al.  Isolating the neural mechanisms of age-related changes in human working memory , 2000, Nature Neuroscience.

[22]  E. Taub,et al.  Constraint-Induced Movement Therapy: a new family of techniques with broad application to physical rehabilitation--a clinical review. , 1999, Journal of rehabilitation research and development.

[23]  L. Cohen,et al.  Cholinergic influences on use-dependent plasticity. , 2002, Journal of neurophysiology.

[24]  M. Berger,et al.  Low-grade hemispheric gliomas in adults: a critical review of extent of resection as a factor influencing outcome. , 2001, Journal of neurosurgery.

[25]  Yon E.udolpii.  On Tumours , 1864, The British and Foreign Medico-Chirurgical Review.

[26]  J. Liepert,et al.  Motor cortex plasticity during constraint-induced movement therapy in stroke patients , 1998, Neuroscience Letters.

[27]  A. Fortuna,et al.  Cerebral oligodendroglioma: prognostic factors and life history. , 1994, Neurosurgery.