Altered cerebral insulin response in transgenic mice expressing the epsilon-4 allele of the human apolipoprotein E gene

[1]  F. Calon,et al.  Can insulin signaling pathways be targeted to transport Aβ out of the brain? , 2015, Front. Aging Neurosci..

[2]  F. Calon,et al.  Human Apolipoprotein E ε4 Expression Impairs Cerebral Vascularization and Blood—Brain Barrier Function in Mice , 2015, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[3]  M. Rosenbloom,et al.  A Single-Dose Pilot Trial of Intranasal Rapid-Acting Insulin in Apolipoprotein E4 Carriers with Mild–Moderate Alzheimer’s Disease , 2014, CNS Drugs.

[4]  A. Marette,et al.  INSULIN REVERSES THE HIGH FAT DIET-INDUCED INCREASE IN BRAIN Aβ AND IMPROVES MEMORY IN AN ANIMAL MODEL OF ALZHEIMER'S DISEASE , 2014, Alzheimer's & Dementia.

[5]  A. Marette,et al.  Protectin DX alleviates insulin resistance by activating a myokine-liver glucoregulatory axis , 2014, Nature Medicine.

[6]  F. Calon,et al.  Reduction in DHA transport to the brain of mice expressing human APOE4 compared to APOE2 , 2014, Journal of neurochemistry.

[7]  F. Calon,et al.  IVIg protects the 3xTg-AD mouse model of Alzheimer’s disease from memory deficit and Aβ pathology , 2014, Journal of Neuroinflammation.

[8]  G. Cole,et al.  Reduced phosphorylation of brain insulin receptor substrate and Akt proteins in apolipoprotein-E4 targeted replacement mice , 2014, Scientific Reports.

[9]  F. Calon,et al.  Brain uptake of a fluorescent vector targeting the transferrin receptor: a novel application of in situ brain perfusion. , 2014, Molecular pharmaceutics.

[10]  C. Hölscher,et al.  Intranasal Insulin as a Treatment for Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence , 2013, CNS Drugs.

[11]  D. Michaelson,et al.  ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice , 2013, Molecular Neurodegeneration.

[12]  F. D. Felice.  Alzheimer’s disease and insulin resistance: translating basic science into clinical applications , 2013 .

[13]  M. Birnbaum,et al.  The Combined Deletion of S6K1 and Akt2 Deteriorates Glycemic Control in a High-Fat Diet , 2012, Molecular and Cellular Biology.

[14]  Berislav V. Zlokovic,et al.  Apolipoprotein E controls cerebrovascular integrity via cyclophilin A , 2012, Nature.

[15]  T. Montine,et al.  Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment A Pilot Clinical Trial , 2011 .

[16]  Samantha J. Brooks,et al.  Brain Insulin Signaling and Alzheimer's Disease: Current Evidence and Future Directions , 2011, Molecular Neurobiology.

[17]  D. Bennett,et al.  Accumulation of Transactive Response DNA Binding Protein 43 in Mild Cognitive Impairment and Alzheimer Disease , 2011, Journal of neuropathology and experimental neurology.

[18]  David M Holtzman,et al.  Human Apoe Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance Nih Public Access , 2022 .

[19]  K. Bales,et al.  Reduced levels of human apoE4 protein in an animal model of cognitive impairment , 2011, Neurobiology of Aging.

[20]  S. Lovestone,et al.  The ε3 and ε4 Alleles of Human APOE Differentially Affect Tau Phosphorylation in Hyperinsulinemic and Pioglitazone Treated Mice , 2011, PloS one.

[21]  Helgi B. Schiöth,et al.  Intranasal insulin as a therapeutic option in the treatment of cognitive impairments , 2011, Experimental Gerontology.

[22]  J. DeFelipe,et al.  Pericellular Innervation of Neurons Expressing Abnormally Hyperphosphorylated Tau in the Hippocampal Formation of Alzheimer's Disease Patients , 2010, Front. Neuroanat..

[23]  W. Frey,et al.  Intranasal delivery to the central nervous system: mechanisms and experimental considerations. , 2010, Journal of pharmaceutical sciences.

[24]  G. Alexander,et al.  Longitudinal modeling of age-related memory decline and the APOE epsilon4 effect. , 2009, The New England journal of medicine.

[25]  M Schwaiger,et al.  Effect of APOE genotype on amyloid plaque load and gray matter volume in Alzheimer disease , 2009, Neurology.

[26]  Avani A. Pendse,et al.  Apolipoprotein E knock-out and knock-in mice: atherosclerosis, metabolic syndrome, and beyond This work was supported by National Institutes of Health Grant HL-042630. Published, JLR Papers in Press, December 5, 2008. , 2009, Journal of Lipid Research.

[27]  D. Bennett,et al.  Apolipoprotein E e4 Allele is Associated With More Rapid Motor Decline in Older Persons , 2009, Alzheimer disease and associated disorders.

[28]  M. Pangalos,et al.  Impact of Apolipoprotein E (ApoE) Polymorphism on Brain ApoE Levels , 2008, The Journal of Neuroscience.

[29]  D. Yang,et al.  Effect of ApoE Genotype on Response to Donepezil in Patients with Alzheimer’s Disease , 2008, Dementia and Geriatric Cognitive Disorders.

[30]  Yu Li,et al.  Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance , 2007, Proceedings of the National Academy of Sciences.

[31]  B. Teter.  Life-span influences of apoE4 on CNS function , 2007, Neurobiology of Aging.

[32]  David A. Bennett,et al.  Postmortem Indices Linking Risk Factors to Cognition: Results From the Religious Order Study and the Memory and Aging Project , 2006, Alzheimer disease and associated disorders.

[33]  G. Schellenberg,et al.  Effects of intranasal insulin on cognition in memory-impaired older adults: Modulation by APOE genotype , 2006, Neurobiology of Aging.

[34]  L. Plum,et al.  Peripheral hyperinsulinemia promotes tau phosphorylation in vivo. , 2005, Diabetes.

[35]  Qian Sun,et al.  Pseudo-phosphorylation of tau at Ser202 and Thr205 affects tau filament formation. , 2005, Brain research. Molecular brain research.

[36]  M. Birnbaum,et al.  Protein Kinase C θ Inhibits Insulin Signaling by Phosphorylating IRS1 at Ser1101* , 2004, Journal of Biological Chemistry.

[37]  G. Pasinetti,et al.  Akt/PKB kinase phosphorylates separately Thr212 and Ser214 of tau protein in vitro. , 2003, Biochimica et biophysica acta.

[38]  Sanjay Asthana,et al.  Insulin Metabolism in Alzheimer’s Disease Differs According to Apolipoprotein E Genotype and Gender , 1999, Neuroendocrinology.

[39]  L. Mucke,et al.  Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[40]  J. Haines,et al.  Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. , 1997, JAMA.

[41]  J. Haines,et al.  Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease: A Meta-analysis , 1997 .

[42]  N. Maeda,et al.  Targeted Replacement of the Mouse Apolipoprotein E Gene with the Common Human APOE3 Allele Enhances Diet-induced Hypercholesterolemia and Atherosclerosis* , 1997, The Journal of Biological Chemistry.

[43]  H. Braak,et al.  Diagnostic Criteria for Neuropathologic Assessment of Alzheimer’s Disease , 1997, Neurobiology of Aging.

[44]  P. Cohen,et al.  Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B , 1995, Nature.

[45]  J. Haines,et al.  Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. , 1993, Science.

[46]  M. Pericak-Vance,et al.  Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[47]  Liqin Zhao,et al.  Human ApoE Isoforms Differentially Modulate Glucose and Amyloid Metabolic Pathways in Female Brain: Evidence of the Mechanism of Neuroprotection by ApoE2 and Implications for Alzheimer's Disease Prevention and Early Intervention. , 2015, Journal of Alzheimer's disease : JAD.

[48]  F. Calon,et al.  The benefit of docosahexaenoic acid for the adult brain in aging and dementia. , 2015, Prostaglandins, leukotrienes, and essential fatty acids.

[49]  Suzanne Craft,et al.  Sex and ApoE genotype differences in treatment response to two doses of intranasal insulin in adults with mild cognitive impairment or Alzheimer's disease. , 2013, Journal of Alzheimer's disease : JAD.

[50]  G. Schellenberg,et al.  Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-beta in memory-impaired older adults. , 2008, Journal of Alzheimer's disease : JAD.

[51]  D. Bennett,et al.  Biochemical Characterization of Aβ and Tau Pathologies in Mild Cognitive Impairment and Alzheimer's Disease , 2007 .