Synovial fibroblasts: key players in rheumatoid arthritis.
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R. Gay | S. Gay | T. Pap | O. Distler | I. Tarner | S Gay | L. Huber | R E Gay | T Pap | L C Huber | O Distler | I Tarner
[1] R. Gay,et al. Cathepsin B in synovial cells at the site of joint destruction in rheumatoid arthritis. , 2010, Arthritis and rheumatism.
[2] G. Kroemer,et al. NF-κB constitutes a potential therapeutic target in high-risk myelodysplastic syndrome , 2005 .
[3] R. Gay,et al. RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via Toll-like receptor 3. , 2005, Arthritis and rheumatism.
[4] K. Hiromura,et al. Expression of interleukin-22 in rheumatoid arthritis: potential role as a proinflammatory cytokine. , 2005, Arthritis and rheumatism.
[5] D. Pisetsky,et al. The induction of matrix metalloproteinase and cytokine expression in synovial fibroblasts stimulated with immune cell microparticles. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[6] R. Gay,et al. The role of Toll-like receptor signalling in the pathogenesis of arthritis. , 2005, Cellular immunology.
[7] C. Der,et al. Enhanced cathepsin L expression is mediated by different Ras effector pathways in fibroblasts and epithelial cells , 2004, International journal of cancer.
[8] U. Müller-Ladner,et al. Gene targeting: Roadmap to future therapies , 2004, Current rheumatology reports.
[9] P. Petrow,et al. Cooperation of Ras- and c-Myc-dependent pathways in regulating the growth and invasiveness of synovial fibroblasts in rheumatoid arthritis. , 2004, Arthritis and rheumatism.
[10] Yoshiya Tanaka,et al. Induction of RANKL expression and osteoclast maturation by the binding of fibroblast growth factor 2 to heparan sulfate proteoglycan on rheumatoid synovial fibroblasts. , 2004, Arthritis and rheumatism.
[11] R. Gay,et al. Galectin-3 is induced in rheumatoid arthritis synovial fibroblasts after adhesion to cartilage oligomeric matrix protein , 2004, Annals of the rheumatic diseases.
[12] T. Nikawa,et al. Relationship between cathepsin B and thrombin in rheumatoid arthritis. , 2004, The Journal of rheumatology.
[13] U. Müller-Ladner,et al. Targeting cathepsin L (CL) by specific ribozymes decreases CL protein synthesis and cartilage destruction in rheumatoid arthritis , 2004, Gene Therapy.
[14] P. Emery,et al. Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. , 2004, The New England journal of medicine.
[15] C. Gondi,et al. Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis , 2004, Oncogene.
[16] D. Alexander,et al. Ribozymes that inhibit the production of matrix metalloproteinase 1 reduce the invasiveness of rheumatoid arthritis synovial fibroblasts. , 2004, Arthritis and rheumatism.
[17] F. Emmrich,et al. Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis. , 2004, Arthritis and rheumatism.
[18] M. Pierer,et al. Chemokine Secretion of Rheumatoid Arthritis Synovial Fibroblasts Stimulated by Toll-Like Receptor 2 Ligands , 2004, The Journal of Immunology.
[19] V. Rangnekar,et al. Suppression of PTEN Expression by NF-κB Prevents Apoptosis , 2004, Molecular and Cellular Biology.
[20] U. Müller-Ladner,et al. p53 in rheumatoid arthritis synovial fibroblasts at sites of invasion , 2003, Annals of the rheumatic diseases.
[21] M. Dougados,et al. Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig. , 2003, The New England journal of medicine.
[22] L. Mayo,et al. Cell Type-specific Expression of the IκB Kinases Determines the Significance of Phosphatidylinositol 3-Kinase/Akt Signaling to NF-κB Activation* , 2003, Journal of Biological Chemistry.
[23] D. Goberdhan,et al. PTEN: tumour suppressor, multifunctional growth regulator and more. , 2003, Human molecular genetics.
[24] U. Müller-Ladner,et al. Gene transfer as a future therapy for rheumatoid arthritis , 2003, Expert opinion on biological therapy.
[25] F. Blasi,et al. The urokinase plasminogen activator system in cancer: Recent advances and implication for prognosis and therapy , 2003, Cancer and Metastasis Reviews.
[26] P. Lipsky,et al. Targeted Therapies in Rheumatology , 2002 .
[27] R. Price,et al. Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: a randomized, double-blind, placebo-controlled, dose-escalation trial. , 2002, Arthritis and rheumatism.
[28] E. Gravallese. Bone destruction in arthritis , 2002, Annals of the rheumatic diseases.
[29] F. Breedveld,et al. Cell-derived microparticles in synovial fluid from inflamed arthritic joints support coagulation exclusively via a factor VII-dependent mechanism. , 2002, Arthritis and rheumatism.
[30] A. Koch,et al. Angiogenesis and chemokines in rheumatoid arthritis and other systemic inflammatory rheumatic diseases , 2002, Journal of cellular and molecular medicine.
[31] R. Gay,et al. FLICE-inhibitory protein expression in synovial fibroblasts and at sites of cartilage and bone erosion in rheumatoid arthritis. , 2002, Arthritis and rheumatism.
[32] A. Silman,et al. Epidemiology and genetics of rheumatoid arthritis , 2002, Arthritis research.
[33] B. Kirkham,et al. Reduction of joint inflammation and bone erosion in rat adjuvant arthritis by treatment with interleukin-17 receptor IgG1 Fc fusion protein. , 2002, Arthritis and rheumatism.
[34] B. Cheson. CHOP plus rituximab--balancing facts and opinion. , 2002, The New England journal of medicine.
[35] L. Joosten,et al. Therapeutic effect of neutralizing endogenous IL-18 activity in the collagen-induced model of arthritis. , 2001, The Journal of clinical investigation.
[36] G. Haines,et al. Differential expression pattern of the antiapoptotic proteins, Bcl-2 and FLIP, in experimental arthritis. , 2001, Arthritis and rheumatism.
[37] R. Zinkernagel. Maternal antibodies, childhood infections, and autoimmune diseases. , 2001, The New England journal of medicine.
[38] C. Fathman,et al. Autoimmune diseases: genes, bugs and failed regulation , 2001, Nature Immunology.
[39] Philippa Marrack,et al. Autoimmune disease: why and where it occurs , 2001, Nature Medicine.
[40] P. Tak,et al. Inhibitor of nuclear factor κB kinase β is a key regulator of synovial inflammation , 2001 .
[41] M. Ikeda,et al. Suppression of arthritis by forced expression of cyclin-dependent kinase inhibitor p21(Cip1) gene into the joints. , 2001, International immunology.
[42] W. Li,et al. Oncostatin M-Induced Matrix Metalloproteinase and Tissue Inhibitor of Metalloproteinase-3 Genes Expression in Chondrocytes Requires Janus Kinase/STAT Signaling Pathway1 , 2001, The Journal of Immunology.
[43] A. Manning,et al. NF-κB Regulation by IκB Kinase-2 in Rheumatoid Arthritis Synoviocytes1 , 2001, The Journal of Immunology.
[44] R. Gay,et al. Retrotransposable L1 elements expressed in rheumatoid arthritis synovial tissue: association with genomic DNA hypomethylation and influence on gene expression. , 2000, Arthritis and rheumatism.
[45] Qingbo Xu,et al. Activation, differential localization, and regulation of the stress-activated protein kinases, extracellular signal-regulated kinase, c-JUN N-terminal kinase, and p38 mitogen-activated protein kinase, in synovial tissue and cells in rheumatoid arthritis. , 2000, Arthritis and rheumatism.
[46] M. Vincenti,et al. Integration of the NF-kappaB and mitogen-activated protein kinase/AP-1 pathways at the collagenase-1 promoter: divergence of IL-1 and TNF-dependent signal transduction in rabbit primary synovial fibroblasts. , 2000, Cytokine.
[47] H. Ronday,et al. Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of a cell surface-targeted plasmin inhibitor. , 2000, Arthritis and rheumatism.
[48] I. Tarner,et al. Gene therapy in autoimmune disease. , 2000, Current opinion in immunology.
[49] C. Brinckerhoff,et al. Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: differential regulation of collagenase 1 and collagenase 3. , 2000, Arthritis and rheumatism.
[50] M Nakajima,et al. [Matrix metalloproteinase inhibitors]. , 2000, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.
[51] U. Müller-Ladner,et al. Expression of sentrin, a novel antiapoptotic molecule, at sites of synovial invasion in rheumatoid arthritis. , 2000, Arthritis and rheumatism.
[52] Kozo Nakamura,et al. Involvement of receptor activator of nuclear factor kappaB ligand/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis. , 2000, Arthritis and rheumatism.
[53] S. Yoshida,et al. The role of p38 mitogen‐activated protein kinase in IL‐6 and IL‐8 production from the TNF‐α‐ or IL‐1β‐stimulated rheumatoid synovial fibroblasts , 2000 .
[54] Thomas Pap,et al. Activation of synovial fibroblasts in rheumatoid arthritis: lack of expression of the tumour suppressor PTEN at sites of invasive growth and destruction , 1999, Arthritis research.
[55] P. Lipsky,et al. Infliximab (chimeric anti-tumour necrosis factor α monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial , 1999, The Lancet.
[56] M. Feldmann,et al. The role of cytokines in the pathogenesis of rheumatoid arthritis. , 1999, Rheumatology.
[57] P. Elliott,et al. Role of the proteasome and NF-kappaB in streptococcal cell wall-induced polyarthritis. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[58] A. Baldwin,et al. NF-kappaB activation provides the potential link between inflammation and hyperplasia in the arthritic joint. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[59] P. Petrow,et al. Cysteine proteinase cathepsin K mRNA is expressed in synovium of patients with rheumatoid arthritis and is detected at sites of synovial bone destruction. , 1998, The Journal of rheumatology.
[60] H. Allgayer,et al. Stimulation of urokinase-type plasminogen activator receptor expression by PMA requires JNK1-dependent and -independent signaling modules , 1998, Oncogene.
[61] T. Ochi,et al. Possible correction of abnormal rheumatoid arthritis synovial cell function by jun D transfection in vitro. , 1998, Arthritis and rheumatism.
[62] M. Schwartz. Integrins, Oncogenes, and Anchorage Independence , 1997, The Journal of cell biology.
[63] G. Huet,et al. Selective induction of the secretion of cathepsins B and L by cytokines in synovial fibroblast-like cells. , 1997, British journal of rheumatology.
[64] J. Hoidal,et al. Induction of urokinase-type plasminogen activator receptor by IL-1 beta. , 1997, American journal of respiratory cell and molecular biology.
[65] T. Sumida,et al. Direct evidence of high DNA binding activity of transcription factor AP-1 in rheumatoid arthritis synovium. , 1997, Arthritis and rheumatism.
[66] C. Brinckerhoff,et al. The AP-1 site and MMP gene regulation: what is all the fuss about? , 1997, Matrix biology : journal of the International Society for Matrix Biology.
[67] E. Korzus,et al. The Mitogen-activated Protein Kinase and JAK-STAT Signaling Pathways Are Required for an Oncostatin M-responsive Element-mediated Activation of Matrix Metalloproteinase 1 Gene Expression* , 1997, The Journal of Biological Chemistry.
[68] M. Lukoschek,et al. Increased expression of integrins on fibroblast-like synoviocytes from rheumatoid arthritis in vitro correlates with enhanced binding to extracellular matrix proteins , 1997, Annals of the rheumatic diseases.
[69] J. Kriegsmann,et al. Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice. , 1996, The American journal of pathology.
[70] M. Rn,et al. The Role of Cytokines in Rheumatoid Arthritis , 1996, Journal of the Royal College of Physicians of London.
[71] S. Dooley,et al. Constitutive expression of c-fos and c-jun, overexpression of ets-2, and reduced expression of metastasis suppressor gene nm23-H1 in rheumatoid arthritis. , 1996, Annals of the rheumatic diseases.
[72] P. Baeuerle,et al. Activation of the transcription factor nuclear factor-kappaB in human inflamed synovial tissue. , 1996, Arthritis and rheumatism.
[73] H. Ishikawa,et al. An immunohistochemical and immunoelectron microscopic study of adhesion molecules in synovial pannus formation in rheumatoid arthritis , 1996, Rheumatology International.
[74] J. Kriegsmann,et al. Comparative analysis of cathepsin L, cathepsin D, and collagenase messenger RNA expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis, by in situ hybridization. , 1995, Arthritis and rheumatism.
[75] J. Kriegsmann,et al. Demonstration of granzyme A and perforin messenger RNA in the synovium of patients with rheumatoid arthritis. , 1995, Arthritis and rheumatism.
[76] J. Kriegsmann,et al. Expression of vascular cell adhesion molecule-1 mRNA and protein in rheumatoid synovium demonstrated by in situ hybridization and immunohistochemistry. , 1995, Laboratory investigation; a journal of technical methods and pathology.
[77] J. Kriegsmann,et al. A new model for rheumatoid arthritis generated by engraftment of rheumatoid synovial tissue and normal human cartilage into SCID mice. , 1994, Arthritis and rheumatism.
[78] M. Kohli,et al. Local proliferation of fibroblast-like synoviocytes contributes to synovial hyperplasia. Results of proliferating cell nuclear antigen/cyclin, c-myc, and nucleolar organizer region staining. , 1994, Arthritis and rheumatism.
[79] H. Kobayashi,et al. Effects of membrane-associated cathepsin B on the activation of receptor-bound prourokinase and subsequent invasion of reconstituted basement membranes. , 1993, Biochimica et biophysica acta.
[80] G. Huet,et al. Stimulation of the secretion of latent cysteine proteinase activity by tumor necrosis factor alpha and interleukin-1. , 1993, Arthritis and rheumatism.
[81] R. Gay,et al. Molecular and cellular mechanisms of joint destruction in rheumatoid arthritis: two cellular mechanisms explain joint destruction? , 1993, Annals of the rheumatic diseases.
[82] M. Sugimura,et al. Inhibition of in vitro ovarian cancer cell invasion by modulation of urokinase-type plasminogen activator and cathepsin B. , 1992, Cancer research.
[83] D. Kioussis,et al. Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. , 1991, The EMBO journal.
[84] J. Mcghee,et al. Expression of the collagenolytic and Ras-induced cysteine proteinase cathepsin L and proliferation-associated oncogenes in synovial cells of MRL/I mice and patients with rheumatoid arthritis. , 1990, Matrix.
[85] M. Sporn,et al. Anchorage-independent growth of synoviocytes from arthritic and normal joints. Stimulation by exogenous platelet-derived growth factor and inhibition by transforming growth factor-beta and retinoids. , 1989, The Journal of clinical investigation.
[86] S. Farmer,et al. Cell adhesion induces expression of growth-associated genes in suspension-arrested fibroblasts. , 1988, Proceedings of the National Academy of Sciences of the United States of America.
[87] H. Fassbender,et al. Histomorphological basis of articular cartilage destruction in rheumatoid arthritis. , 1983, Collagen and related research.
[88] L. Mayo,et al. Cell type-specific expression of the IkappaB kinases determines the significance of phosphatidylinositol 3-kinase/Akt signaling to NF-kappa B activation. , 2004, The Journal of biological chemistry.
[89] V. Rangnekar,et al. Suppression of PTEN expression by NF-kappa B prevents apoptosis. , 2004, Molecular and cellular biology.
[90] V. Sukhatme,et al. Spontaneous expression of immediately-early response genes c-fos and egr-1 in collagenase-producing rheumatoid synovial fibroblasts , 2004, Rheumatology International.
[91] H. Bergmeister,et al. Single and combined inhibition of tumor necrosis factor, interleukin-1, and RANKL pathways in tumor necrosis factor-induced arthritis: effects on synovial inflammation, bone erosion, and cartilage destruction. , 2004, Arthritis and rheumatism.
[92] F. Breedveld,et al. Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of TIMP-1 and TIMP-3 , 2003, Gene Therapy.
[93] J. Smith,et al. Rheumatoid arthritis--a molecular understanding. , 2002, Annals of internal medicine.
[94] P. Tak,et al. Inhibitor of nuclear factor kappaB kinase beta is a key regulator of synovial inflammation. , 2001, Arthritis and rheumatism.
[95] A. Manning,et al. NF-kappa B regulation by I kappa B kinase-2 in rheumatoid arthritis synoviocytes. , 2001, Journal of immunology.
[96] H. Eibel,et al. Measurement of transcription factor c-fos and EGR-1 mRNA transcription levels in synovial tissue by quantitative RT-PCR , 1997, Rheumatology International.
[97] E. Kontny,et al. Modified expression of c-Fos and c-Jun proteins and production of interleukin-1 beta in patients with rheumatoid arthritis. , 1995, Clinical and experimental rheumatology.
[98] M. Pagano,et al. "In vitro" study of basement membrane degradation by the cysteine proteinases, cathepsins B, B-like and L. Digestion of collagen IV, laminin, fibronectin, and release of gelatinase activities from basement membrane fibronectin. , 1993, Biological chemistry Hoppe-Seyler.