Histopathological study of endometrium in abnormal uterine bleeding

Background: Histopathological evaluation of endometrial samples is essential in the workup of abnormal uterine bleeding. This study was carried out to evaluate patterns of endometrial histological findings in women with abnormal uterine bleeding and to correlate histopathological findings with clinical features. Materials and Methods: One hundred and twenty two patients with diagnosis of abnormal uterine bleeding underwent endometrial sampling. The slides stained with Hematoxylin and Eosin stain were studied. Results: The predominant endometrial histopathological finding was proliferative endometrium 32 cases (26.23%) followed by simple hyperplasia without atypia 22 cases (18.03%). Malignant lesions were more common in patients more than 40 years of age and comprised of 7 cases (5.74%) of all cases. Atrophic endometrium was most common finding in postmenopausal bleeding 8 cases (28.6%) followed by endometrial carcinoma 5 cases (17.9%). Conclusion: Histopathological examination of endometrium should be done generously in women presenting with abnormal uterine bleeding especially after the age of 40 years to rule out malignant pathology. Journal of Pathology of Nepal (2012) Vol. 2, 297-300 DOI: http://dx.doi.org/10.3126/jpn.v2i4.6882

[1]  J. Merla.  Histomorphological Profile of Endometrium inPerimenopausal Bleeding. , 2013 .

[2]  Amit H Agravat,et al.  HISTOPATHOLOGICAL STUDY OF ENDOMETRIUM IN DYSFUNCTIONAL UTERINE BLEEDING , 2013 .

[3]  Y. Tyagi,et al.  Morphological Spectrum of Endometrium in Patients Presenting with Dysfunc- tional Uterine Bleeding , 2012 .

[4]  J. Donnez.  Menometrorrhagia during the premenopause: an overview , 2011, Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.

[5]  Thanka Johnson,et al.  Study of Endometrial Pathology in Abnormal Uterine Bleeding , 2011, Journal of obstetrics and gynaecology of India.

[6]  W. Iqbal,et al.  Menstrual irregularities with excessive blood loss: a clinico-pathological correlation. , 2005, JPMA. The Journal of the Pakistan Medical Association.

[7]  G. Dangal.  A study of endometrium of patients with abnormal uterine bleeding at Chitwan Valley. , 2003, Kathmandu University medical journal.

[8]  Lumsden,et al.  Menstruation and menstrual abnormality , 2003 .

[9]  L. Sargeant,et al.  Histopathological findings in women with postmenopausal bleeding in Jamaica. , 2002, The West Indian medical journal.

[10]  N. Todorović,et al.  Results of histopathological findings of endometrial changes , 2002 .

[11]  S. Silverberg.  Problems in the Differential Diagnosis of Endometrial Hyperplasia and Carcinoma , 2000, Modern Pathology.

[12]  L. Melton,et al.  Endometrial cancer in Olmsted County, MN: trends in incidence, risk factors and survival. , 2000, Annals of epidemiology.

[13]  B. Ottesen,et al.  Risk factors among young women with endometrial cancer: a Danish case-control study. , 2000, American journal of obstetrics and gynecology.

[14]  M. Munro.  Abnormal uterine bleeding in the reproductive years. Part I--pathogenesis and clinical investigation. , 1999, The Journal of the American Association of Gynecologic Laparoscopists.

[15]  C. Spencer,et al.  Endometrial assessment re‐visited , 1999, British journal of obstetrics and gynaecology.

[16]  S. Živković,et al.  [Analysis of pathohistological results from the uterine mucosa 1965-1998 at the gynecology department in Senta]. , 1999, Medicinski pregled.

[17]  T. Agorastos,et al.  Histopathological findings of the endometrium in patients with dysfunctional uterine bleeding. , 1996, Clinical and experimental obstetrics & gynecology.

[18]  L. Mattsson,et al.  Histopathological findings in women with postmenopausal bleeding , 1995, British journal of obstetrics and gynaecology.

[19]  S. Thakur,et al.  Epidemiological evaluation of excessive and/or irregular uterine bleeding. , 1993, Indian journal of public health.

[20]  M. Kafrissen,et al.  Endometrial morphology in asymptomatic postmenopausal women. , 1991, American journal of obstetrics and gynecology.

[21]  S. Tripathy,et al.  Place of aspiration cytology in dysfunctional uterine bleeding. , 1990, Journal of the Indian Medical Association.

[22]  M. P. David,et al.  Histopathological Findings in 226 Women with Post‐Menopausal Uterine Bleeding , 1986, Acta obstetricia et gynecologica Scandinavica.

[23]  C. Massafra,et al.  Critical review of dilatation and curettage in the diagnosis of malignant pathology of the endometrium. , 1986, European journal of gynaecological oncology.

[24]  A. Ferenczy,et al.  Endometrial hyperplasia and carcinoma. Are ultrastructural, biochemical and immunocytochemical studies useful in distinguishing between them? , 1982, Pathology, research and practice.