The E box motif CAGGTG enhances somatic hypermutation without enhancing transcription.
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U. Storb | Nayun Kim | S. Longerich | A. Longacre | H. Shen | N. Michael
[1] Hong Sun,et al. mSharp-1/DEC2, a Basic Helix-Loop-Helix Protein Functions as a Transcriptional Repressor of E Box Activity and Stra13 Expression* , 2003, Journal of Biological Chemistry.
[2] F. Papavasiliou,et al. AID Mediates Hypermutation by Deaminating Single Stranded DNA , 2003, The Journal of experimental medicine.
[3] U. Storb,et al. A novel cytidine deaminase AIDs in the delivery of error-prone polymerases to immunoglobulin genes. , 2003, DNA repair.
[4] M. Nussenzweig,et al. Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand , 2003, Nature Immunology.
[5] F. Alt,et al. Transcription-targeted DNA deamination by the AID antibody diversification enzyme , 2003, Nature.
[6] M. Goodman,et al. Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[7] R. Wall,et al. Somatic hypermutation of the B cell receptor genes B29 (Igβ, CD79b) and mb1 (Igα, CD79a) , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[8] J. Stavnezer,et al. Immunoglobulin Genes: Generating Diversity with AID and UNG , 2002, Current Biology.
[9] D. Barnes,et al. Immunoglobulin Isotype Switching Is Inhibited and Somatic Hypermutation Perturbed in UNG-Deficient Mice , 2002, Current Biology.
[10] T. Honjo,et al. AID Enzyme-Induced Hypermutation in an Actively Transcribed Gene in Fibroblasts , 2002, Science.
[11] Alberto Martin,et al. Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas , 2002, Nature.
[12] C. Murre. Helix-Loop-Helix Proteins , 2002 .
[13] V. Gray-Schopfer,et al. Increased Transcription Levels Induce Higher Mutation Rates in a Hypermutating Cell Line1 , 2001, The Journal of Immunology.
[14] U. Storb,et al. Somatic hypermutation of immunoglobulin and non-immunoglobulin genes. , 2001, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.
[15] U. Storb,et al. The TATA binding protein, c-Myc and survivin genes are not somatically hypermutated, while Ig and BCL6 genes are hypermutated in human memory B cells. , 2000, International immunology.
[16] A. Feeney,et al. E2A and EBF act in synergy with the V(D)J recombinase to generate a diverse immunoglobulin repertoire in nonlymphoid cells. , 2000, Molecular cell.
[17] C. Murre,et al. Helix-Loop-Helix Proteins: Regulators of Transcription in Eucaryotic Organisms , 2000, Molecular and Cellular Biology.
[18] C. Murre,et al. E2A activity is induced during B‐cell activation to promote immunoglobulin class switch recombination , 1999, The EMBO journal.
[19] L. Wysocki,et al. Predicting regional mutability in antibody V genes based solely on di- and trinucleotide sequence composition. , 1999, Journal of immunology.
[20] P. Isaacson,et al. Nonimmunoglobulin gene hypermutation in germinal center B cells. , 1999, Blood.
[21] P. Casali,et al. Induction of Ig somatic hypermutation and class switching in a human monoclonal IgM+ IgD+ B cell line in vitro: definition of the requirements and modalities of hypermutation. , 1999, Journal of immunology.
[22] L. Pasqualucci,et al. BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[23] U. Storb,et al. Somatic Hypermutation of an Artificial Test Substrate Within an Igκ Transgene , 1998, The Journal of Immunology.
[24] K. Rajewsky,et al. Somatic hypermutation in the heavy chain locus correlates with transcription. , 1998, Immunity.
[25] U. Storb,et al. Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes. , 1998, Science.
[26] J. Hackett,et al. Cis‐acting sequences that affect somatic hypermutation of Ig genes , 1998, Immunological reviews.
[27] D. Winter,et al. Dual enigma of somatic hypermutation of immunoglobulin variable genes: targeting and mechanism , 1998, Immunological reviews.
[28] A. Feeney,et al. Both E12 and E47 allow commitment to the B cell lineage. , 1997, Immunity.
[29] T. Kadesch,et al. Phosphorylation of E47 as a potential determinant of B-cell-specific activity , 1996, Molecular and cellular biology.
[30] J. Choi,et al. E47 activates the Ig‐heavy chain and TdT loci in non‐B cells. , 1996, The EMBO journal.
[31] T. Kadesch,et al. B-cell-specific DNA binding by an E47 homodimer , 1995, Molecular and cellular biology.
[32] C. Milstein,et al. Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region , 1994, Cell.
[33] R. Kingston,et al. Preferred sequences for DNA recognition by the TAL1 helix-loop-helix proteins , 1994, Molecular and cellular biology.
[34] U. Storb,et al. PU.1 is a component of a multiprotein complex which binds an essential site in the murine immunoglobulin lambda 2-4 enhancer , 1993, Molecular and cellular biology.
[35] Samuel Hellman,et al. Important advances in oncology , 1991 .
[36] B. Roizman,et al. Binding of the herpes simplex virus major regulatory protein to viral DNA. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[37] D. Nicolae,et al. Effects of sequence and structure on the hypermutability of immunoglobulin genes. , 2002, Immunity.
[38] L. Loeb,et al. Molecular aspects of somatic hypermutation of immunoglobulin genes. , 1999, Cold Spring Harbor symposia on quantitative biology.
[39] K. Offit,et al. BCL-6 in diffuse large-cell lymphomas. , 1996, Important advances in oncology.
[40] U. Storb,et al. Somatic hypermutation of immunoglobulin genes is linked to transcription initiation. , 1996, Immunity.