Diagnosis of transient electrokinetic flow in microfluidic channels

Measuring the electro-osmotic velocity distributions in microchannels is usually performed for steady-state electrokinetic flows. Characterizing time-dependent electrokinetic flows is of importance to the development of microfluidic devices such as rapid capillary electrophoretic separation system, ac pumps, novel micromixers, etc. In this paper, we use a micron-resolution particle image velocimetry (micro-PIV) based phase locking technique with an ordinary PIV charge coupled device (CCD) camera to carry out an experimental study of the transient electrokinetic flow in microchannels by synchronizing different trigger signals for the laser, CCD camera, and in-house designed high-voltage switch. With the transient micro-PIV technique, we further propose a method to decouple the particle electrophoretic velocity from the micro-PIV measured velocity and to determine the zeta potential of the channel wall. The time evolution of the full-field, electro-osmotic velocity distributions in both open- and closed-end...

[1]  D. Telionis.  Unsteady Viscous Flows , 1981 .

[2]  R. Zare,et al.  Current-monitoring method for measuring the electroosmotic flow rate in capillary zone electrophoresis , 1988 .

[3]  D. J. Harrison,et al.  Micromachining a Miniaturized Capillary Electrophoresis-Based Chemical Analysis System on a Chip , 1993, Science.

[4]  D. J. Harrison,et al.  Micromachining of capillary electrophoresis injectors and separators on glass chips and evaluation of flow at capillary intersections , 1994 .

[5]  S. Jacobson,et al.  High-Speed Separations on a Microchip , 1994 .

[6]  A. Woolley,et al.  Ultra-high-speed DNA sequencing using capillary electrophoresis chips. , 1995, Analytical chemistry.

[7]  A. Manz,et al.  Micellar electrokinetic chromatography separations and analyses of biological samples on a cyclic planar microstructure. , 1996, Analytical chemistry.

[8]  J. Lyklema,et al.  Dynamic Aspects of Electrophoresis and Electroosmosis: A New Fast Method for Measuring Particle Mobilities , 1997 .

[9]  Yang,et al.  Electrokinetic Effects on Pressure-Driven Liquid Flows in Rectangular Microchannels , 1997, Journal of colloid and interface science.

[10]  P. Paul,et al.  Imaging of Pressure- and Electrokinetically Driven Flows through Open Capillaries. , 1998, Analytical chemistry.

[11]  D. Beebe,et al.  A particle image velocimetry system for microfluidics , 1998 .

[12]  Howard H. Hu,et al.  Numerical simulation of electroosmotic flow. , 1998, Analytical chemistry.

[13]  S. Jacobson,et al.  Computer simulations of electrokinetic transport in microfabricated channel structures. , 1998, Analytical chemistry.

[14]  C. Culbertson,et al.  Microchip Structures for Submillisecond Electrophoresis , 1998 .

[15]  S. Jacobson,et al.  Microfluidic devices for electrokinetically driven parallel and serial mixing , 1999 .

[16]  S. K. Griffiths,et al.  Conditions for similitude between the fluid velocity and electric field in electroosmotic flow , 1999, Analytical chemistry.

[17]  C. Culbertson,et al.  Electroosmotically induced hydraulic pumping on microchips: differential ion transport , 2000, Analytical chemistry.

[18]  D. Erickson,et al.  An Improved Method of Determining the ζ-Potential and Surface Conductance , 2000 .

[19]  C. Culbertson,et al.  Microchip devices for high-efficiency separations. , 2000, Analytical chemistry.

[20]  M. Tarlov,et al.  Control of flow direction in microfluidic devices with polyelectrolyte multilayers. , 2000, Analytical chemistry.

[21]  S. Jacobson,et al.  Computer simulations of electrokinetic injection techniques in microfluidic devices , 2000, Analytical chemistry.

[22]  D. Ehrlich,et al.  Optimization of high-performance DNA sequencing on short microfabricated electrophoretic devices. , 2000, Analytical chemistry.

[23]  S. Wereley,et al.  A PIV Algorithm for Estimating Time-Averaged Velocity Fields , 2000 .

[24]  C. Meinhart,et al.  The flow structure inside a microfabricated inkjet printhead , 2000, Journal of Microelectromechanical Systems.

[25]  J. Santiago.  Electroosmotic flows in microchannels with finite inertial and pressure forces. , 2001, Analytical chemistry.

[26]  Electroosmotic flow in composite microchannels and implications in microcapillary electrophoresis systems. , 2001, Analytical chemistry.

[27]  T. Johnson,et al.  Imaging of electroosmotic flow in plastic microchannels. , 2001, Analytical chemistry.

[28]  Dongqing Li,et al.  Measurement of the Zeta Potential of Gas Bubbles in Aqueous Solutions by Microelectrophoresis Method , 2001 .

[29]  C. Mastrangelo,et al.  Microfluidics and Biomems , 2001 .

[30]  N. Penner,et al.  Nanoliter capillary electrochromatography columns based on collocated monolithic support structures molded in poly(dimethyl siloxane) , 2001, Electrophoresis.

[31]  Y. Inoue,et al.  The ultrasonic velocity profile measurement of flow structure in the near field of a square free jet , 2002 .

[32]  S. Wereley,et al.  Advanced Algorithms for Microscale Particle Image Velocimetry , 2002 .

[33]  V. Studer,et al.  Fabrication of microfluidic devices for AC electrokinetic fluid pumping , 2002 .

[34]  M. J. Kim,et al.  Electro-osmosis-driven micro-channel flows: A comparative study of microscopic particle image velocimetry measurements and numerical simulations , 2002 .

[35]  A. West,et al.  Electrokinetic flow control for composition modulation in a microchannel , 2002 .

[36]  K. Takehara,et al.  Particle tracking techniques for electrokinetic microchannel flows. , 2002, Analytical chemistry.

[37]  C. Meinhart,et al.  Measurement of AC Electrokinetic Flows , 2003 .

[38]  C. Henry,et al.  Experimental studies of electroosmotic flow dynamics in microfabricated devices during current monitoring experiments. , 2003, Analytical chemistry.

[39]  Chun Yang,et al.  Modeling of Electroosmotic Flow and Capillary Electrophoresis with the Joule Heating Effect: The Nernst−Planck Equation versus the Boltzmann Distribution , 2003 .

[40]  R. Allen,et al.  Prediction of electrokinetic and pressure flow in a microchannel T-junction , 2003 .

[41]  Dongqing Li,et al.  Electroosmotic velocity profiles in microchannels , 2003 .

[42]  D. Erickson,et al.  Integrated microfluidic devices , 2004 .

[43]  J. Santiago,et al.  Instability of electrokinetic microchannel flows with conductivity gradients , 2004 .

[44]  Marcos,et al.  Frequency-dependent laminar electroosmotic flow in a closed-end rectangular microchannel. , 2004, Journal of colloid and interface science.

[45]  J. Abate,et al.  Multi‐precision Laplace transform inversion , 2004 .

[46]  E. Biddiss,et al.  Heterogeneous Surface Charge Enhanced Micromixing for Electrokinetic Flows , 2004 .

[47]  David Sinton,et al.  Microscale flow visualization , 2004 .

[48]  J. Santiago,et al.  A method for determining electrophoretic and electroosmotic mobilities using AC and DC electric field particle displacements. , 2004, Journal of colloid and interface science.

[49]  J. Eijkel,et al.  An AC electroosmotic micropump for circular chromatographic applications. , 2004, Lab on a chip.

[50]  Howard A. Stone,et al.  ENGINEERING FLOWS IN SMALL DEVICES , 2004 .

[51]  A. Conlisk,et al.  An experimental study of electro-osmotic flow in rectangular microchannels , 2004, Journal of Fluid Mechanics.

[52]  N. Aubry,et al.  Electroosmotic mixing in microchannels. , 2004, Lab on a chip.

[53]  S. Bhattacharyya,et al.  Electro-osmotic flow in two-dimensional charged micro- and nanochannels , 2005, Journal of Fluid Mechanics.

[54]  H. N. Unni,et al.  Brownian dynamics simulation and experimental study of colloidal particle deposition in a microchannel flow. , 2005, Journal of colloid and interface science.

[55]  M. Zolfigol,et al.  Biomimetic aromatization of Hantzsch 1,4-dihydropyridines with sodium periodate catalyzed by a new polystyrene-bound manganese porphyrin , 2006 .