Evidence of Health Impacts of Sulfate-and Nitrate-Containing Particles in Ambient Air

Ambient particulate matter (PM) is a complex mixture of inorganic and organic compounds. The U.S. Environmental Protection Agency (EPA) regulates PM as a criteria pollutant and promulgates National Ambient Air Quality Standards for it. The PM indicator is based on mass concentration, unspecified as to chemical composition, for specific size fractions. The numerical standards are based on epidemiologic evidence of associations between the various size-related particle mass concentrations as indicators and excess mortality and cardiorespiratory health effects as endpoints. The U.S. National Research Council has stated that more research is needed to differentiate the apparent health effects associated with different particle chemical constituents. Sulfate and nitrate constitute a significant portion of the particle mass in the atmosphere, but are accompanied by similar amounts of carbonaceous material, along with low concentrations of various species, including bioactive organic compounds and redox cycling metals. Extensive animal and human toxicology data show no significant effects for particles consisting only of sulfate and nitrate compounds at levels in excess of ambient air concentrations. A few epidemiologic studies, including both short-term time-series studies and long-term cohort studies, have included the sulfate content of PM as a specific variable in health effect analyses. There are much less data for nitrate. The results from the epidemiologic studies with PM sulfate are inconsistent. A detailed analysis of the time-series epidemiological studies shows that PM sulfate has a weaker “risk factor” than PM2.5 for health effects. Since sulfate is correlated with PM2.5, this result is inconsistent with sulfate having a strong health influence. However, there are many limitations with these types of studies that warrant caution for any comparison between a chemical component and mass concentration. In total, the epidemiologic and toxicologic evidence provide little or no support for a causal association of PM sulfate and health risk at ambient concentrations. For nitrate-containing PM, virtually no epidemiological data exist. Limited toxicological evidence does not support a causal association between particulate nitrate compounds and excess health risks. There are some possible indirect processes through which sulfate and nitrate in PM may affect health-related endpoints, including interactions with certain metal species and a linkage with production of secondary organic matter. There is insufficient evidence to include or exclude these processes as being potentially important to PM-associated health risk.

[1]  Xianglin Shi,et al.  The role of oxygen free radicals in occupational and environmental lung diseases. , 1997, Environmental health perspectives.

[2]  Richard L. Smith.  Invited commentary: Timescale-dependent mortality effects of air pollution. , 2003, American journal of epidemiology.

[3]  S. Friedlander,et al.  The Submicron Atmospheric Aerosol as a Carrier of Reactive Chemical Species: Case of Peroxides , 1998 .

[4]  Juan Zhang,et al.  Infant Mortality and Air Pollution: A Comprehensive Analysis of U.S. Data for 1990 , 2000, Journal of the Air & Waste Management Association.

[5]  Joel Schwartz,et al.  The Effects of Air Pollution on Hospitalizations for Cardiovascular Disease in Elderly People in Australian and New Zealand Cities , 2006, Environmental health perspectives.

[6]  D. Bates,et al.  Particulate air pollution. , 1996, Thorax.

[7]  J. Miller,et al.  PM2.5 Constituents and Related Air Quality Variables As Predictors of Survival in a Cohort of U.S. Military Veterans , 2006, Inhalation toxicology.

[8]  Flemming Cassee,et al.  Atmospheric Secondary Inorganic Particulate Matter: The Toxicological Perspective as a Basis for Health Effects Risk Assessment , 2003, Inhalation toxicology.

[9]  Suresh H. Moolgavkar,et al.  Air Pollution and Daily Mortality in Philadelphia , 1995, Epidemiology.

[10]  S L Zeger,et al.  The National Morbidity, Mortality, and Air Pollution Study. Part I: Methods and methodologic issues. , 2000, Research report.

[11]  D Krewski,et al.  The role of particulate size and chemistry in the association between summertime ambient air pollution and hospitalization for cardiorespiratory diseases. , 1997, Environmental health perspectives.

[12]  S. Moolgavkar.  Fine Particles and Mortality , 2006, Inhalation toxicology.

[13]  R. Kamens,et al.  Heterogeneous Atmospheric Aerosol Production by Acid-Catalyzed Particle-Phase Reactions , 2002, Science.

[14]  J. Schwartz,et al.  Is Daily Mortality Associated Specifically with Fine Particles? , 1996, Journal of the Air & Waste Management Association.

[15]  Richard L. Verrier,et al.  Association of Air Pollution with Increased Incidence of Ventricular Tachyarrhythmias Recorded by Implanted Cardioverter Defibrillators , 2005, Environmental health perspectives.

[16]  A. Wexler,et al.  Particles do not increase vapor deposition in human airways , 1998 .

[17]  J C Bailar,et al.  The association between daily mortality and ambient air particle pollution in Montreal, Quebec. 2. Cause-specific mortality. , 2001, Environmental research.

[18]  G. Oberdörster,et al.  Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles , 2005, Environmental health perspectives.

[19]  R. Klemm,et al.  Daily Mortality and Air Pollution in Atlanta: Two Years of Data from ARIES , 2004, Inhalation toxicology.

[20]  P. Paatero,et al.  PM source apportionment and health effects: 1. Intercomparison of source apportionment results , 2006, Journal of Exposure Science and Environmental Epidemiology.

[21]  J. Caldwell,et al.  Review of the national ambient air quality standards for particulate matter: Policy assessment of scientific and technical information. OAQPS staff paper. Final report , 1996 .

[22]  J. Schwartz,et al.  The National Morbidity, Mortality, and Air Pollution Study. Part II: Morbidity and mortality from air pollution in the United States. , 2000, Research report.

[23]  J. Enstrom,et al.  Fine Particulate Air Pollution and Total Mortality Among Elderly Californians, 1973–2002 , 2005, Inhalation toxicology.

[24]  Richard Doll,et al.  Mortality in relation to smoking: 22 years' observations on female British doctors. , 1980, British medical journal.

[25]  Polina Maciejczyk,et al.  Effects of Subchronic Exposures to Concentrated Ambient Particles (CAPs) in Mice: VIII. Source-Related Daily Variations in In Vitro Responses to CAPs , 2005, Inhalation toxicology.

[26]  J. Hemby,et al.  National air quality and emissions trends report, 1994. Annual report , 1992 .

[27]  M. Apte,et al.  An Exploratory Analysis of the Relationship Between Mortality and the Chemical Composition of Airborne Particulate Matter , 2000, Inhalation Toxicology.

[28]  J. Schwartz,et al.  DIABETES ENHANCES VULNERABILITY TO PARTICULATE AIR POLLUTION-ASSOCIATED IMPAIRMENT IN VASCULAR REACTIVITY AND ENDOTHELIAL FUNCTION , 2004, Circulation.

[29]  山崎 甞録,et al.  Photochemical Reactions , 1942, Nature.

[30]  B. Holma.  Effects of inhaled acids on airway mucus and its consequences for health. , 1989, Environmental health perspectives.

[31]  Response to “A Critique of ‘Fine Particulate Air Pollution and Total Mortality Among Elderly Californians, 1973–2002” By Bert Brunekreef, PhD, and Gerard Hoek, PhD , 2006 .

[32]  W. Mcdonnell,et al.  Relationships of mortality with the fine and coarse fractions of long-term ambient PM10 concentrations in nonsmokers , 2000, Journal of Exposure Analysis and Environmental Epidemiology.

[33]  Francesca Dominici,et al.  Revised Analyses of the National Morbidity, Mortality, and Air Pollution Study: Mortality Among Residents Of 90 Cities , 2005, Journal of toxicology and environmental health. Part A.

[34]  P. Catalano,et al.  Inhaled concentrated ambient particles are associated with hematologic and bronchoalveolar lavage changes in canines. , 2000, Environmental health perspectives.

[35]  B Rachet,et al.  A flexible modeling approach to estimating the component effects of smoking behavior on lung cancer. , 2004, Journal of clinical epidemiology.

[36]  K. T. Whitby.  THE PHYSICAL CHARACTERISTICS OF SULFUR AEROSOLS , 1978 .

[37]  M. Brauer,et al.  Exposure of Chronic Obstructive Pulmonary Disease Patients to Particulate Matter: Relationships between Personal and Ambient Air Concentrations , 2000, Journal of the Air & Waste Management Association.

[38]  Sabit Cakmak,et al.  Associations between Short-Term Changes in Nitrogen Dioxide and Mortality in Canadian Cities , 2004, Archives of environmental health.

[39]  B. Coull,et al.  Concentrated ambient air particles induce vasoconstriction of small pulmonary arteries in rats. , 2002, Environmental health perspectives.

[40]  William F. Christensen,et al.  Workgroup Report: Workshop on Source Apportionment of Particulate Matter Health Effects—Intercomparison of Results and Implications , 2005, Environmental health perspectives.

[41]  S. Grambow,et al.  The Role of Soluble Components in Ambient Fine Particles-Induced Changes in Human Lungs and Blood , 2003, Inhalation toxicology.

[42]  Walter John,et al.  Characteristics of the Berner Impactor for Sampling Inorganic Ions , 1988 .

[43]  Antonella Zanobetti,et al.  Diabetes Enhances Vulnerability to Particulate Air Pollution–Associated Impairment in Vascular Reactivity and Endothelial Function , 2004, Circulation.

[44]  T. Grahame,et al.  Evaluating the Health Risk from Secondary Sulfates in Eastern North American Regional Ambient Air Particulate Matter , 2005, Inhalation toxicology.

[45]  J C McDonald,et al.  Mortality in a cohort of vermiculite miners exposed to fibrous amphibole in Libby, Montana , 2004, Occupational and Environmental Medicine.

[46]  Gary Koop,et al.  Measuring the health effects of air pollution: to what extent can we really say that people are dying from bad air? , 2004 .

[47]  D. Dockery,et al.  Particulate air pollution as a predictor of mortality in a prospective study of U.S. adults. , 1995, American journal of respiratory and critical care medicine.

[48]  R. Burnett,et al.  Spatial Analysis of the Air Pollution--Mortality Relationship in the Context of Ecologic Confounders , 2003, Journal of toxicology and environmental health. Part A.

[49]  L. C. Chen,et al.  Furnace-generated acid aerosols: speciation and pulmonary effects. , 1989, Environmental health perspectives.

[50]  J. Miller,et al.  THE WASHINGTON UNIVERSITY–EPRI VETERANS' COHORT MORTALITY STUDY: Preliminary Results , 2000, Inhalation toxicology.

[51]  S. Moolgavkar.  A review and critique of the EPA's rationale for a fine particle standard. , 2005, Regulatory toxicology and pharmacology : RTP.

[52]  C I Davidson,et al.  Semicontinuous measurements of organic carbon and acidity during the Pittsburgh Air Quality Study: implications for acid-catalyzed organic aerosol formation. , 2006, Environmental science & technology.

[53]  Bert Brunekreef,et al.  Daily Mortality and Air Pollution in the Netherlands , 2000, Journal of the Air & Waste Management Association.

[54]  A. Ledbetter,et al.  Variable pulmonary responses from exposure to concentrated ambient air particles in a rat model of bronchitis. , 2000, Toxicological sciences : an official journal of the Society of Toxicology.

[55]  G. Gee,et al.  Particle-size Analysis , 2018, SSSA Book Series.

[56]  T. Lumley,et al.  Time series analyses of air pollution and health: straining at gnats and swallowing camels? , 2003, Epidemiology.

[57]  B. Coull,et al.  Inhalation of concentrated ambient air particles exacerbates myocardial ischemia in conscious dogs. , 2002, Environmental health perspectives.

[58]  Howard Frumkin,et al.  Ambient Air Pollution and Cardiovascular Emergency Department Visits , 2004, Epidemiology.

[59]  R. Devlin,et al.  Concentrated ambient air particles induce mild pulmonary inflammation in healthy human volunteers. , 2000, American journal of respiratory and critical care medicine.

[60]  Brent Coull,et al.  Rapid increases in the steady-state concentration of reactive oxygen species in the lungs and heart after particulate air pollution inhalation. , 2002, Environmental health perspectives.

[61]  D. Fairley.  Daily mortality and air pollution in Santa Clara County, California: 1989-1996. , 1999, Environmental Health Perspectives.

[62]  R. Burnett,et al.  Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. , 2002, JAMA.

[63]  G A Norris,et al.  Associations between air pollution and mortality in Phoenix, 1995-1997. , 2000, Environmental health perspectives.

[64]  J Schwartz,et al.  Traffic related pollution and heart rate variability in a panel of elderly subjects , 2005, Thorax.

[65]  S. J. Rothenberg,et al.  Surface Area, Adsorption, and Desorption Studies on Indoor Dust Samples , 1989 .

[66]  C. N. Hewitt,et al.  The atmospheric chemistry of sulphur and nitrogen in power station plumes , 2001 .

[67]  Frederick W. Lipfert,et al.  Traffic density as a surrogate measure of environmental exposures in studies of air pollution health effects: Long-term mortality in a cohort of US veterans , 2006 .

[68]  Jingxia Li,et al.  Role of bioavailable iron in coal dust-induced activation of activator protein-1 and nuclear factor of activated T cells: difference between Pennsylvania and Utah coal dusts. , 2002, American journal of respiratory cell and molecular biology.

[69]  M G Apte,et al.  Estimating separately personal exposure to ambient and nonambient particulate matter for epidemiology and risk assessment: why and how. , 2001, Journal of the Air and Waste Management Association.

[70]  J. Schwartz,et al.  Association of fine particulate matter from different sources with daily mortality in six U.S. cities. , 2000, Environmental health perspectives.

[71]  R. Burnett,et al.  The Relationship Among TSP, PM10, PM2.5, and Inorganic Constituents of Atmospheric Participate Matter at Multiple Canadian Locations , 1997 .

[72]  Richard T Burnett,et al.  Associations between ambient air pollution and daily mortality among persons with diabetes and cardiovascular disease. , 2006, Environmental research.

[73]  C I Davidson,et al.  The sizes of particulate sulfate and nitrate in the atmosphere--a review. , 1987, JAPCA.

[74]  Qi Zhang,et al.  Time- and size-resolved chemical composition of submicron particles in Pittsburgh: Implications for aerosol sources and processes , 2005 .

[75]  Philip K. Hopke,et al.  Identification of Sources of Phoenix Aerosol by Positive Matrix Factorization , 2000, Journal of the Air & Waste Management Association.

[76]  Kazuhiko Ito,et al.  Spatial variation of PM2.5 chemical species and source-apportioned mass concentrations in New York City , 2004 .

[77]  D. Tolsma,et al.  Associations and Lags between Air Pollution and Acute Respiratory Visits in an Ambulatory Care Setting: 25-Month Results from the Aerosol Research and Inhalation Epidemiological Study , 2004, Journal of the Air & Waste Management Association.

[78]  R. Burnett,et al.  Spatial Analysis of Air Pollution and Mortality in Los Angeles , 2005, Epidemiology.

[79]  J. Sarnat,et al.  Assessing the Relationship between Personal Particulate and Gaseous Exposures of Senior Citizens Living in Baltimore, MD , 2000, Journal of the Air & Waste Management Association.

[80]  J. Vandenberg,et al.  Research priorities: airborne particulate matter , 2001 .

[81]  D. Dockery,et al.  Health Effects of Fine Particulate Air Pollution: Lines that Connect , 2006, Journal of the Air & Waste Management Association.

[82]  P. Bhave,et al.  The chemical composition of atmospheric ultrafine particles , 2000, Philosophical Transactions of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences.

[83]  R. Burnett,et al.  Fine particulate air pollution and all-cause mortality within the Harvard Six-Cities Study: variations in risk by period of exposure. , 2002, Annals of epidemiology.

[84]  A. Peters,et al.  Can We Identify Sources of Fine Particles Responsible for Exercise-Induced Ischemia on Days with Elevated Air Pollution? The ULTRA Study , 2006, Environmental health perspectives.

[85]  Bree L van,et al.  Toxicity of Ambient Particulate Matter II. Acutetoxicity study in asthmatic mice following 3-day exposure to fine ammonium ferrosulfate, a model compound for secondaryaerosol of PM10 , 1998 .

[86]  M. Corn,et al.  THE IRRITANT POTENCY OF ZINC AMMONIUM SULFATE OF DIFFERENT PARTICLE SIZES. , 1963, American Industrial Hygiene Association journal.

[87]  Michael J Daniels,et al.  The National Morbidity, Mortality, and Air Pollution Study. Part III: PM10 concentration-response curves and thresholds for the 20 largest US cities. , 2004, Research report.

[88]  H. Frumkin,et al.  Ambient Air Pollution and Respiratory Emergency Department Visits , 2005, Epidemiology.

[89]  A. Wexler,et al.  Growth and neutralization of sulfate aerosols in human airways. , 1996, Journal of applied physiology.

[90]  D. Dockery,et al.  An association between air pollution and mortality in six U.S. cities. , 1993, The New England journal of medicine.

[91]  J C Bailar,et al.  The association between daily mortality and ambient air particle pollution in Montreal, Quebec. 1. Nonaccidental mortality. , 2001, Environmental research.

[92]  R. Brook,et al.  Acute Blood Pressure Responses in Healthy Adults During Controlled Air Pollution Exposures , 2005, Environmental health perspectives.

[93]  R. Burnett,et al.  Association of particulate matter components with daily mortality and morbidity in urban populations. , 2000, Research report.

[94]  B. Turpin,et al.  Tissue injury following inhalation of fine particulate matter and hydrogen peroxide is associated with altered production of inflammatory mediators and antioxidants by alveolar macrophages. , 2001, Toxicology and applied pharmacology.

[95]  Daniel Krewski,et al.  Rejoinder: Reanalysis of the Harvard Six Cities Study and American Cancer Society Study of Particulate Air Pollution and Mortality , 2003 .

[96]  A. Ghio,et al.  Sulfate content correlates with iron concentrations in ambient air pollution particles. , 1999, Inhalation toxicology.

[97]  Valter Maurino,et al.  Photochemical reactions in the tropospheric aqueous phase and on particulate matter. , 2006, Chemical Society reviews.

[98]  Morton Lippmann,et al.  PM Source Apportionment for Short-Term Cardiac Function Changes in ApoE−/− Mice , 2005, Environmental health perspectives.

[99]  Michael O. Finkelstein.  Combining the Evidence , 2009 .

[100]  Daniel Krewski,et al.  Reanalysis of the Harvard Six Cities Study and the American Cancer Society Study of Particulate Air , 2000 .

[101]  S. Walters,et al.  Particulate matter and daily mortality and hospital admissions in the west midlands conurbation of the United Kingdom: associations with fine and coarse particles, black smoke and sulphate , 2001, Occupational and environmental medicine.

[102]  Joel Schwartz,et al.  Diabetes, Obesity, and Hypertension May Enhance Associations between Air Pollution and Markers of Systemic Inflammation , 2006, Environmental health perspectives.

[103]  J. Schwartz,et al.  Reduction in fine particulate air pollution and mortality: Extended follow-up of the Harvard Six Cities study. , 2006, American journal of respiratory and critical care medicine.

[104]  G. M. Hidy,et al.  The Health Relevance of Ambient Particulate Matter Characteristics: Coherence of Toxicological and Epidemiological Inferences , 2006, Inhalation toxicology.

[105]  T STATEMEN,et al.  Revised Analyses of Time-Series Studies of Air Pollution and Health , 2003 .

[106]  R. Brook,et al.  Relative Contributions of PM2.5 Chemical Constituents to Acute Arterial Vasoconstriction in Humans , 2004, Inhalation toxicology.

[107]  W. Mcdonnell,et al.  Long-term inhalable particles and other air pollutants related to mortality in nonsmokers. , 1999, American journal of respiratory and critical care medicine.

[108]  D. Costa,et al.  Bioavailable transition metals in particulate matter mediate cardiopulmonary injury in healthy and compromised animal models. , 1997, Environmental health perspectives.

[109]  Michigan.,et al.  Toxicological profile for dichloropropenes , 2008 .

[110]  R. Burnett,et al.  The Association between Sulfate Air Pollution and Mortality at the County Scale: An Exploration of the Impact of Scale on a Long-Term Exposure Study , 2003, Journal of toxicology and environmental health. Part A.

[111]  G. Hidy,et al.  Using Factor Analysis to Attribute Health Impacts to Particulate Pollution Sources , 2004, Inhalation toxicology.

[112]  E. Bedrick,et al.  Lung Toxicity of Ambient Particulate Matter from Southeastern U.S. Sites with Different Contributing Sources: Relationships between Composition and Effects , 2006, Environmental health perspectives.

[113]  R. Wyzga,et al.  Daily Mortality in the Philadelphia Metropolitan Area and Size-Classified Particulate Matter , 2000, Journal of the Air & Waste Management Association.

[114]  Merlise A. Clyde,et al.  Model uncertainty and health effect studies for particulate matter , 2000 .

[115]  Robert P Hodyss,et al.  Particle phase acidity and oligomer formation in secondary organic aerosol. , 2004, Environmental science & technology.

[116]  Ronald W. Williams,et al.  Personal exposures to PM2.5 mass and trace elements in Baltimore, MD, USA , 2001 .

[117]  Paxticulate Xir Polll.  The Association between Daily Morta ’ lity and Ambient Air Particle Pollution in Montreal , Quebec , 2002 .

[118]  R. Burnett,et al.  A time-series study of air pollution, socioeconomic status, and mortality in Vancouver, Canada , 2003, Journal of Exposure Analysis and Environmental Epidemiology.

[119]  B. Coull,et al.  Lung inflammation induced by concentrated ambient air particles is related to particle composition. , 2002, American journal of respiratory and critical care medicine.

[120]  Lung-Chi Chen,et al.  Speciation and pulmonary effects of acidic SOx formed on the surface of ultrafine zinc oxide aerosols , 1988 .

[121]  B. Finlayson‐Pitts,et al.  Chemistry of the Upper and Lower Atmosphere , 2000 .

[122]  J. Seinfeld,et al.  Atmospheric equilibrium model of sulfate and nitrate aerosols—II. Particle size analysis , 1984 .

[123]  P. Saxena,et al.  Water-soluble organics in atmospheric particles: A critical review of the literature and application of thermodynamics to identify candidate compounds , 1996 .

[124]  F. Dominici,et al.  Combining evidence on air pollution and daily mortality from the 20 largest US cities: a hierarchical modelling strategy , 2000 .

[125]  K. Dreher,et al.  Particulate Matter Physicochemistry and Toxicology: In Search of Causality—A Critical Perspective , 2000, Inhalation toxicology.

[126]  U. Kodavanti,et al.  ALTERED GENE EXPRESSION PROFILES OF RAT LUNG IN RESPONSE TO AN EMISSION PARTICULATE AND ITS METAL CONSTITUENTS , 2002, Journal of toxicology and environmental health. Part A.