IXDC 1 promotes tumor proliferation and cell adhesion mediated rug resistance ( CAM-DR ) via enhancing p-Akt in Non-Hodgkin ’ s ymphomas u

DIX domain containing 1 (DIXDC1), is a human homolog of Ccd1, a DIX domain containing protein in zebrafish. The present study was undertaken to determine the expression and biologic function of DIXDC1 in Non-Hodgkin’s lymphoma (NHL). Clinically, we detected that the expression of DIXDC1 was significantly lower in the indolent lymphomas compared with the progressive lymphomas by immunohistochemistry analysis. Functionally, we found that DIXDC1 could promote cell proliferation via modulating cell cycle progression and PI3K/AKT signaling pathway in NHLs. Moreover, we confirmed that DIXDC1 was involved in the process of lymphoma cell adhesion mediated drug resistance (CAM-

[1]  P. Wei,et al.  DIXDC 1 Activates the Wnt Signaling Pathway and Promotes Gastric Cancer Cell Invasion and Metastasis , 2016 .

[2]  Xiaohong Xu,et al.  Sam68 regulates cell proliferation and cell adhesion‐mediated drug resistance (CAM‐DR) via the AKT pathway in non‐Hodgkin's lymphoma , 2015, Cell proliferation.

[3]  Sheng Wei,et al.  c-Myc plays part in drug resistance mediated by bone marrow stromal cells in acute myeloid leukemia. , 2015, Leukemia research.

[4]  Yuankai Shi,et al.  CRM1 as a new therapeutic target for non-Hodgkin lymphoma. , 2015, Leukemia research.

[5]  E. Wang,et al.  DIXDC1 increases the invasion and migration ability of non‐small‐cell lung cancer cells via the PI3K‐AKT/AP‐1 pathway , 2014, Molecular carcinogenesis.

[6]  Dongbing Ding,et al.  Low expression of dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin in non-Hodgkin lymphoma and a significant correlation with β2-microglobulin , 2014, Medical Oncology.

[7]  M. Salih,et al.  Immunophenotyping of Non-Hodgkin's lymphomas in Sudan , 2014, The Pan African medical journal.

[8]  H. Nakayama,et al.  Overexpression of fibronectin confers cell adhesion-mediated drug resistance (CAM-DR) against 5-FU in oral squamous cell carcinoma cells. , 2014, International journal of oncology.

[9]  J. Bradner,et al.  A microenvironment-mediated c-Myc/miR-548m/HDAC6 amplification loop in non-Hodgkin B cell lymphomas. , 2013, The Journal of clinical investigation.

[10]  S. Maxwell,et al.  Non-Hodgkin’s B-cell lymphoma: Advances in molecular strategies targeting drug resistance , 2013, Experimental biology and medicine.

[11]  Nong Zhang,et al.  Nrf2 Pathway Regulates Multidrug-Resistance-Associated Protein 1 in Small Cell Lung Cancer , 2013, PloS one.

[12]  M. Fukayama,et al.  Expression of multidrug resistance 1 gene in B‐cell lymphomas: association with follicular dendritic cells , 2013, Histopathology.

[13]  A. K. Church,et al.  Bone marrow stromal cells protect lymphoma B‐cells from rituximab‐induced apoptosis and targeting integrin α‐4‐β‐1 (VLA‐4) with natalizumab can overcome this resistance , 2011, British Journal of Haematology.

[14]  A. Rosenwald,et al.  The microenvironment in mature B-cell malignancies: a target for new treatment strategies. , 2009, Blood.

[15]  J. Tao,et al.  Lymphoma cell adhesion-induced expression of B cell-activating factor of the TNF family in bone marrow stromal cells protects non-Hodgkin's B lymphoma cells from apoptosis , 2009, Leukemia.

[16]  S. Fulda,et al.  Identification of a novel switch in the dominant forms of cell adhesion-mediated drug resistance in glioblastoma cells , 2008, Oncogene.

[17]  W. Dalton,et al.  Cell adhesion induces p27Kip1-associated cell-cycle arrest through down-regulation of the SCFSkp2 ubiquitin ligase pathway in mantle-cell and other non-Hodgkin B-cell lymphomas. , 2006, Blood.

[18]  Xianshu Wang,et al.  DIXDC1 isoform, l-DIXDC1, is a novel filamentous actin-binding protein. , 2006, Biochemical and biophysical research communications.

[19]  B. Ducommun,et al.  Cell adhesion regulates CDC25A expression and proliferation in acute myeloid leukemia. , 2006, Cancer Research.

[20]  M. Masu,et al.  Identification and differential expression of multiple isoforms of mouse Coiled-coil-DIX1 (Ccd1), a positive regulator of Wnt signaling. , 2005, Brain research. Molecular brain research.

[21]  B. Hancock,et al.  Non-Hodgkin lymphoma , 2003, The Lancet.

[22]  M. Masu,et al.  Ccd1, a Novel Protein with a DIX Domain, Is a Positive Regulator in the Wnt Signaling during Zebrafish Neural Patterning , 2003, Current Biology.

[23]  I. Flinn.  Lymphoma therapy: the challenges ahead. , 2002, Current opinion in oncology.