Powerful Continuous‐Flow Hydrogenation by using Poly(dimethyl)silane‐Supported Palladium Catalysts

We developed poly(dimethyl)silane‐supported Pd catalysts that are readily prepared from Pd(OAc)2, poly(dimethyl)silane, and Al2O3. The immobilization was achieved for the first time with a support that does not contain benzene rings. The Pd catalyst thus prepared was found to have higher hydrogenation activity than Pd/C. Furthermore, the catalyst was used in continuous‐flow hydrogenation with various substrates, including simple liquid substrates (neat) and dissolved solid substrates. Vegetable oils, squalenes, and phosphatidylcholine were successfully hydrogenated on gram to kilogram scales.

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