Effect of a Guaiazulene-Containing Ointment on Nipple and Areola Area Health of Women

Guaiazulene-containing ointments are routinely used for breast care during breastfeeding. It has also been proposed that nipple and areola area of non-breastfeeding women might benefit from use of this azulene. In a study with 51 women, it was investigated whether the use of a guaiazulene-containing ointment (Garmastan?) would improve look, elasticity and sensitivity of nipple and areola area within 4 month daily application. About one third of study participants reported improvement in sensitivity, elasticity and look of the investigated area of the breast. Assessment of doctors revealed a clear improvement in elasticity and sensitivity of the nipple and areola area over study period. Nearly all women wished to continue the use of the ointment after end of the study. In conclusion, the use of Garmastan? ointment is able to improve sensitivity and elasticity of the nipple and areola area of the breasts of non-breastfeeding women.

[1]  H. Turkez,et al.  In vitro cytotoxic, genotoxic and antioxidant/oxidant effects of guaiazulene on human lymphocytes , 2015 .

[2]  S. Kurtoğlu,et al.  Guaiazulene: a new treatment option for recalcitrant diaper dermatitis in NICU patients , 2013, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.

[3]  J. Harvey,et al.  Nipple-areolar complex: normal anatomy and benign and malignant processes. , 2009, Radiographics : a review publication of the Radiological Society of North America, Inc.

[4]  C. Meston,et al.  Nipple/Breast stimulation and sexual arousal in young men and women. , 2006, The journal of sexual medicine.

[5]  M. Yayla,et al.  Prevention of Nipple Cracks With Guaiazulene Versus Breast Milk in Nursing Mother: A Randomized, Controlled, Double-Blind Trial , 2005 .

[6]  S. Berti,et al.  Atopic dermatitis exclusively localized on nipples and areolas. , 2005, Pediatric dermatology.

[7]  A. Rebora,et al.  The anti‐inflammatory activity of azulene , 2001, Journal of the European Academy of Dermatology and Venereology : JEADV.

[8]  A. Kourounakis,et al.  Antioxidant Activity of Guaiazulene and Protection Against Paracetamol Hepatotoxicity in Rats , 1997, The Journal of pharmacy and pharmacology.

[9]  H. Schnieden Pharmacology and toxicology. , 1978, The Medical annual.

[10]  W. Daniel,et al.  [EXPERIENCES WITH GARMASTAN OINTMENT AS MASTITIS PREVENTIVE AGENT]. , 1964, Wiener medizinische Wochenschrift.