FOUR score and Glasgow Coma Scale in predicting outcome of comatose patients: A pooled analysis

The Glasgow Coma Scale (GCS) has positioned itself as a major prognostic marker for outcome in comatose patients. The recent introduction of a more detailed scale—the Full Outline of Unresponsiveness (FOUR) score—has provided the opportunity to analyze its predictive value and compare it to GCS as the current standard. Several prospective studies have validated the FOUR score as a reliable tool in assessing stuporous and comatose patients (figure e-1 on the Neurology ® Web site at www.neurology.org). In this pooled analysis, we compare the value of low sumscores to predict outcome in the GCS and FOUR score. ### Methods. In this study, we analyzed the data of all previously performed prospective studies and used a summary receiver operating characteristic curve to predict outcome after presentation with an acute neurologic condition. Prior tabulated data from 4 prospective studies1,–,4 were reanalyzed. Poor outcome …