The application of ITS is seen as very promising to address the negative consequences of road transport. However, the mechanisms which have an impact on the CO2 emissions are very complex, while not much about this is known from existing studies. Therefore, the EC commissioned this study, ‘Impact of Information and Communication Technologies on Energy Efficiency in Road Transport’, with the objective to perform an analysis on how ICT can contribute to reduction of emissions of CO2 and possible other greenhouse gases (from here on called “CO2 emissions”) through innovative technologies. The study is intended to support the policy making process, by providing an assessment of the most important systems and models able to resolve some of the challenges related to clean and efficient mobility. The result will help to define DG INFSO’s role in the ICT debate.