Neuropsychological aspects of frontal lobe epilepsy

While most neuropsychological studies in focal epilepsies are concerned with temporal lobe epilepsy (TLE), only few investigations aim cognitive functioning in unresected patients with frontal lobe epilepsy (FLE). Following functional models arising from lesional studies, we evaluated patients with TLE (21 left, 17 right) and FLE (6 left, 17 right) with respect to attention and speed, motor coordination, verbal/nonverbal fluency, concept formation, response inhibition, anticipatory behavior and memory span. The following results were obtained. When compared to TLE, FLE was associated with significantly poorer results in almost all tests, fluency tests being the exception. No group differences were found with respect to the lateralization of the epileptic focus or the presence or absence of cerebral lesions. Factor analysis of the tests indicated that different subfunctions (speed, STM, motor coordination, response maintenance and inhibition) were assessed. A particular cognitive pattern of impaired motor coordination or response inhibition appeared to be characteristic for patients with FLE.

[1]  B. Milner,et al.  Performance of complex arm and facial movements after focal brain lesions , 1981, Neuropsychologia.

[2]  Brenda Milner,et al.  Design fluency: The invention of nonsense drawings after focal cortical lesions , 1977, Neuropsychologia.

[3]  B. Milner,et al.  Effects of frontal or temporal lobectomy on the use of advance information in a choice reaction time task , 1989, Neuropsychologia.

[4]  C. A. Marsan,et al.  Cerebral Seizures of Probable Orbitofrontal Origin , 1975, Epilepsia.

[5]  Jerome Engel,et al.  Surgical treatment of the epilepsies , 1993 .

[6]  Richard H. Mattson,et al.  Memory Function in Focal Epilepsy: A Comparison of Non-Surgical, Unilateral Temporal Lobe and Frontal Lobe Samples , 1980, Cortex.

[7]  J Bancaud,et al.  Clinical semiology of frontal lobe seizures. , 1992, Advances in neurology.

[8]  Tim Shallice,et al.  The Involvement of the Frontal Lobes in Cognitive Estimation , 1978, Cortex.

[9]  D. Stuss,et al.  The Frontal Lobes , 1986 .

[10]  Arthur L. Benton,et al.  Differential behavioral effects in frontal lobe disease , 1968 .

[11]  D. Spencer,et al.  Complex partial seizures of frontal lobe origin , 1985, Annals of neurology.

[12]  E. Perret.  The left frontal lobe of man and the suppression of habitual responses in verbal categorical behaviour. , 1974, Neuropsychologia.

[13]  A. Ramier,et al.  [Respective rôles of frontal lesions and lesion lateralization in "verbal fluency" deficiencies]. , 1970, Revue neurologique.

[14]  J. Fuster.  Prefrontal Cortex , 2018 .

[15]  Karl H. Pribram,et al.  Psychophysiology of the frontal lobes , 1973 .

[16]  Marianne Regard,et al.  Children's Production on Verbal and Non-Verbal Fluency Tasks , 1982, Perceptual and motor skills.

[17]  B. Milner,et al.  Observations on spontaneous facial expression after focal cerebral excisions and after intracarotid injection of sodium amytal , 1981, Neuropsychologia.

[18]  M. Petrides.  Deficits on conditional associative-learning tasks after frontal- and temporal-lobe lesions in man , 1985, Neuropsychologia.

[19]  Brenda Milner,et al.  Differential effects of frontal-lobe lesions on cognitive estimation and spatial memory , 1984, Neuropsychologia.

[20]  L. Fegersten,et al.  Frontal epileptogenic foci and their clinical correlations , 1961 .

[21]  T. Shallice.  From Neuropsychology to Mental Structure: Converging Operations: Specific Syndromes and Evidence from Normal Subjects , 1988 .

[22]  B. Milner,et al.  Deficits on subject-ordered tasks after frontal- and temporal-lobe lesions in man , 1982, Neuropsychologia.

[23]  T. Shallice.  Specific impairments of planning. , 1982, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[24]  B. Milner,et al.  Interhemispheric differences in the localization of psychological processes in man. , 1971, British medical bulletin.

[25]  A. Luria.  The Working Brain , 1973 .

[26]  A. Luria.  Higher Cortical Functions in Man , 1980, Springer US.

[27]  B. Milner.  Effects of Different Brain Lesions on Card Sorting: The Role of the Frontal Lobes , 1963 .

[28]  K. Pribram.  THE PRIMATE FRONTAL CORTEX - EXECUTIVE OF THE BRAIN , 1973 .

[29]  M. Brazier,et al.  Epilepsy: its phenomena in man , 1973 .

[30]  W. Nauta.  The problem of the frontal lobe: a reinterpretation. , 1971, Journal of psychiatric research.

[31]  A. Wyler,et al.  Wisconsin Card Sorting Test performance in patients with complex partial seizures of temporal-lobe origin. , 1988, Journal of clinical and experimental neuropsychology.

[32]  T. Pedley,et al.  Clinical and electroencephalographic characteristics of midline parasagittal foci , 1981, Annals of neurology.