The expression of TNF‐α converting enzyme at the site of ruptured plaques in patients with acute myocardial infarction

Background  Tumour necrosis factor‐α (TNF‐α) converting enzyme (TACE) plays an essential role in the TNF‐α shedding process, which could affect the outcome of acute myocardial infarction (AMI). However, it remains unclear whether it originates from the ruptured plaque or represents a systemic process. This study analysed TACE‐mediated TNF‐α shedding at the site of ruptured plaques in AMI patients and compared them with a systemic mechanism.

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