Localization of HIV-1 Vpr to the nuclear envelope: Impact on Vpr functions and virus replication in macrophages

[1]  F. Margottin-Goguet,et al.  HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase. , 2009, Cell cycle.

[2]  Xiao-Fang Yu,et al.  DDB1 and Cul4A Are Required for Human Immunodeficiency Virus Type 1 Vpr-Induced G2 Arrest , 2007, Journal of Virology.

[3]  M. Washburn,et al.  Lentiviral Vpr usurps Cul4–DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle , 2007, Proceedings of the National Academy of Sciences.

[4]  A. Finzi,et al.  HIV-1 Vpr-Mediated G2 Arrest Involves the DDB1-CUL4AVPRBP E3 Ubiquitin Ligase , 2007, PLoS pathogens.

[5]  E. Zimmerman,et al.  HIV-1 Vpr activates the G2 checkpoint through manipulation of the ubiquitin proteasome system , 2007, Virology Journal.

[6]  Jean-Christophe Rain,et al.  HIV1 Vpr Arrests the Cell Cycle by Recruiting DCAF1/VprBP, a Receptor of the Cul4-DDB1 Ubiquitin Ligase , 2007, Cell cycle.

[7]  S. Benichou,et al.  HIV-1 Vpr-Induced Apoptosis Is Cell Cycle Dependent and Requires Bax but Not ANT , 2006, PLoS pathogens.

[8]  Ariberto Fassati,et al.  HIV infection of non-dividing cells: a divisive problem , 2006, Retrovirology.

[9]  R. Myers,et al.  tRNAs Promote Nuclear Import of HIV-1 Intracellular Reverse Transcription Complexes , 2006, PLoS biology.

[10]  Elizabeth J. Tran,et al.  Dynamic Nuclear Pore Complexes: Life on the Edge , 2006, Cell.

[11]  Michael Emerman,et al.  Retroviral infection of non-dividing cells: old and new perspectives. , 2006, Virology.

[12]  M. Emerman,et al.  The Cell Cycle Independence of HIV Infections Is Not Determined by Known Karyophilic Viral Elements , 2005, PLoS pathogens.

[13]  E. Zimmerman,et al.  ATR and GADD45α mediate HIV-1 Vpr-induced apoptosis , 2005, Cell Death and Differentiation.

[14]  Xiang-Jiao Yang,et al.  Multisite protein modification and intramolecular signaling , 2005, Oncogene.

[15]  S. Benichou,et al.  The Vpr protein from HIV-1: distinct roles along the viral life cycle , 2005, Retrovirology.

[16]  Simon C Watkins,et al.  Corrigendum to “Structure-functional analysis of human immunodeficiency virus type 1 (HIV-1) Vpr: role of leucine residues in Vpr-mediated transactivation and virus replication” [Virology 328 (2004) 89–100] , 2005 .

[17]  E. Zimmerman,et al.  ATR and GADD45alpha mediate HIV-1 Vpr-induced apoptosis. , 2005, Cell death and differentiation.

[18]  Simon C Watkins,et al.  Structure-functional analysis of human immunodeficiency virus type 1 (HIV-1) Vpr: role of leucine residues on Vpr-mediated transactivation and virus replication. , 2004, Virology.

[19]  M. Kamata,et al.  Increased Levels of Wee-1 Kinase in G2 Are Necessary for Vpr- and Gamma Irradiation-Induced G2 Arrest , 2004, Journal of Virology.

[20]  S. Benichou,et al.  Vpr-mediated Incorporation of UNG2 into HIV-1 Particles Is Required to Modulate the Virus Mutation Rate and for Replication in Macrophages* , 2004, Journal of Biological Chemistry.

[21]  P. Petit,et al.  Siva-1 and an Alternative Splice Form Lacking the Death Domain, Siva-2, Similarly Induce Apoptosis in T Lymphocytes via a Caspase-Dependent Mitochondrial Pathway1 , 2004, The Journal of Immunology.

[22]  W. Muller,et al.  The contribution of monocyte infection and trafficking to viral persistence, and maintenance of the viral reservoir in HIV infection , 2003, Journal of leukocyte biology.

[23]  A. Greenway,et al.  Studies with GFP-Vpr fusion proteins: induction of apoptosis but ablation of cell-cycle arrest despite nuclear membrane or nuclear localization. , 2003, Virology.

[24]  Manuel C. Peitsch,et al.  SWISS-MODEL: an automated protein homology-modeling server , 2003, Nucleic Acids Res..

[25]  A. Badley,et al.  Vpr R77Q is associated with long-term nonprogressive HIV infection and impaired induction of apoptosis. , 2003, The Journal of clinical investigation.

[26]  F. Barré-Sinoussi,et al.  Fcγ Receptor-Mediated Suppression of Human Immunodeficiency Virus Type 1 Replication in Primary Human Macrophages , 2003, Journal of Virology.

[27]  B. Roques,et al.  NMR structure of the HIV-1 regulatory protein VPR. , 2003, Journal of molecular biology.

[28]  I. Chen,et al.  Depletion of Wee-1 Kinase Is Necessary for both Human Immunodeficiency Virus Type 1 Vpr- and Gamma Irradiation-Induced Apoptosis , 2003, Journal of Virology.

[29]  Einar Hallberg,et al.  Docking of HIV-1 Vpr to the Nuclear Envelope Is Mediated by the Interaction with the Nucleoporin hCG1* , 2002, The Journal of Biological Chemistry.

[30]  D. Green,et al.  HIV-1 Vpr Induces Apoptosis through Caspase 9 in T Cells and Peripheral Blood Mononuclear Cells* , 2002, The Journal of Biological Chemistry.

[31]  M. Emerman,et al.  Evidence for a cytopathogenicity determinant in HIV-1 Vpr , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[32]  M. L. Penn,et al.  HIV-1 Vpr Enhances Viral Burden by Facilitating Infection of Tissue Macrophages but Not Nondividing CD4+ T Cells , 2001, The Journal of experimental medicine.

[33]  W. Greene,et al.  Dynamic Disruptions in Nuclear Envelope Architecture and Integrity Induced by HIV-1 Vpr , 2001, Science.

[34]  C. Depienne,et al.  Interaction of human immunodeficiency virus type 1 Vpr with the HHR23A DNA repair protein does not correlate with multiple biological functions of Vpr. , 2001, Virology.

[35]  C. Depienne,et al.  Cellular distribution and karyophilic properties of matrix, integrase, and Vpr proteins from the human and simian immunodeficiency viruses. , 2000, Experimental cell research.

[36]  U. Schubert,et al.  Human Immunodeficiency Virus Type 1 Vpr Protein Is Incorporated into the Virion in Significantly Smaller Amounts than Gag and Is Phosphorylated in Infected Cells , 2000, Journal of Virology.

[37]  M. Kamata,et al.  Induction of apoptosis by the Vpr protein of human immunodeficiency virus type 1 occurs independently of G(2) arrest of the cell cycle. , 2000, Virology.

[38]  L. M. Mansky,et al.  The Interaction of Vpr with Uracil DNA Glycosylase Modulates the Human Immunodeficiency Virus Type 1 In Vivo Mutation Rate , 2000, Journal of Virology.

[39]  M. Kamata,et al.  Two Putative α-Helical Domains of Human Immunodeficiency Virus Type 1 Vpr Mediate Nuclear Localization by at Least Two Mechanisms , 2000, Journal of Virology.

[40]  I. Chen,et al.  Human Immunodeficiency Virus Type 1 Vpr Induces Apoptosis through Caspase Activation , 2000, Journal of Virology.

[41]  L. Selig,et al.  Mutational Analysis of Vpr-Induced G2Arrest, Nuclear Localization, and Cell Death in Fission Yeast , 1999, Journal of Virology.

[42]  L. Selig,et al.  Interaction with the p6 Domain of the Gag Precursor Mediates Incorporation into Virions of Vpr and Vpx Proteins from Primate Lentiviruses , 1999, Journal of Virology.

[43]  M. Malim,et al.  Interaction of the Human Immunodeficiency Virus Type 1 Vpr Protein with the Nuclear Pore Complex , 1998, Journal of Virology.

[44]  G. Blobel,et al.  Viral Protein R Regulates Docking of the HIV-1 Preintegration Complex to the Nuclear Pore Complex* , 1998, The Journal of Biological Chemistry.

[45]  É. Cohen,et al.  Human immunodeficiency virus type 1 Vpr localization: nuclear transport of a viral protein modulated by a putative amphipathic helical structure and its relevance to biological activity. , 1998, Journal of molecular biology.

[46]  P. Silver,et al.  HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection. , 1998, Genes & development.

[47]  M. Nowak,et al.  HIV-1 Vpr increases viral expression by manipulation of the cell cycle: A mechanism for selection of Vpr in vivo , 1998, Nature Medicine.

[48]  F. Hanaoka,et al.  Human immunodeficiency virus type 1 Vpr interacts with HHR23A, a cellular protein implicated in nucleotide excision DNA repair , 1997, Journal of virology.

[49]  D. Weiner,et al.  Nuclear import, virion incorporation, and cell cycle arrest/differentiation are mediated by distinct functional domains of human immunodeficiency virus type 1 Vpr , 1997, Journal of virology.

[50]  Luigi Naldini,et al.  Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo , 1997, Nature Biotechnology.

[51]  M. A. Vodicka,et al.  Uracil DNA glycosylase specifically interacts with Vpr of both human immunodeficiency virus type 1 and simian immunodeficiency virus of sooty mangabeys, but binding does not correlate with cell cycle arrest , 1997, Journal of virology.

[52]  N. Guex,et al.  SWISS‐MODEL and the Swiss‐Pdb Viewer: An environment for comparative protein modeling , 1997, Electrophoresis.

[53]  R. Knoblauch,et al.  Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr , 1995, Journal of virology.

[54]  F. Boisvert,et al.  Mutagenic analysis of human immunodeficiency virus type 1 Vpr: role of a predicted N-terminal alpha-helical structure in Vpr nuclear localization and virion incorporation , 1995, Journal of virology.

[55]  E. Freed,et al.  Role of the basic domain of human immunodeficiency virus type 1 matrix in macrophage infection , 1995, Journal of virology.

[56]  R. Connor,et al.  Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes. , 1995, Virology.

[57]  M C Peitsch,et al.  The Swiss-3DImage collection and PDB-Browser on the World-Wide Web. , 1995, Trends in biochemical sciences.

[58]  M. Emerman,et al.  The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[59]  D. Kolson,et al.  Distinct effects in primary macrophages and lymphocytes of the human immunodeficiency virus type 1 accessory genes vpr, vpu, and nef: mutational analysis of a primary HIV-1 isolate. , 1994, Virology.

[60]  W. Paxton,et al.  Incorporation of Vpr into human immunodeficiency virus type 1 virions: requirement for the p6 region of gag and mutational analysis , 1993, Journal of virology.

[61]  G. F. Joyce,et al.  Randomization of genes by PCR mutagenesis. , 1992, PCR methods and applications.

[62]  M. Matsuda,et al.  Human immunodeficiency virus vpr gene encodes a virion-associated protein. , 1990, AIDS research and human retroviruses.

[63]  M. Matsuda,et al.  Open reading frame vpr of simian immunodeficiency virus encodes a virion-associated protein , 1990, Journal of virology.

[64]  S. Adam,et al.  Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors , 1990, The Journal of cell biology.

[65]  J. Sodroski,et al.  Human immunodeficiency virus vpr product is a virion-associated regulatory protein , 1990, Journal of virology.