Inhibition of lysophosphatidic acid increase by prestorage whole blood leukoreduction in autologous CPDA‐1 whole blood

Lysophosphatidylcholine (LPC) has been implicated in the onset of transfusion‐related acute lung injury (TRALI). In plasma, LPC is converted to lysophosphatidic acid (LPA) by autotaxin (ATX). The effect of leukoreduction in the accumulation of these bioactive lipids and ATX in human autologous blood has not been fully investigated.

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