Genetics of Hypertension and Cardiovascular Disease and Their Interconnected Pathways: Lessons from Large Studies

[1]  L. Schild.  The epithelial sodium channel and the control of sodium balance. , 2010, Biochimica et biophysica acta.

[2]  L. Citterio,et al.  Genetics of primary hypertension: the clinical impact of adducin polymorphisms. , 2010, Biochimica et biophysica acta.

[3]  Christian Gieger,et al.  Genome-wide association analysis identifies multiple loci related to resting heart rate. , 2010, Human molecular genetics.

[4]  T. Matsuo,et al.  Nitric oxide enhancement and blood pressure decrease in patients with metabolic syndrome using soy protein or fish oil. , 2010, Arquivos brasileiros de endocrinologia e metabologia.

[5]  E. Benjamin,et al.  Evaluation of non-synonymous NPPA single nucleotide polymorphisms in atrial fibrillation. , 2010, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

[6]  J. Wade,et al.  Multigene kinase network, kidney transport, and salt in essential hypertension. , 2010, Kidney international.

[7]  A. Hofman,et al.  Genomic Variation Associated With Mortality Among Adults of European and African Ancestry With Heart Failure: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium , 2010, Circulation. Cardiovascular genetics.

[8]  B. Egan,et al.  US trends in prevalence, awareness, treatment, and control of hypertension, 1988-2008. , 2010, JAMA.

[9]  S. Uchida.  Pathophysiological roles of WNK kinases in the kidney , 2010, Pflügers Archiv - European Journal of Physiology.

[10]  A. J. Williams,et al.  Ryanodine receptor mutations in arrhythmia: The continuing mystery of channel dysfunction , 2010, FEBS letters.

[11]  Chao-shu Tang,et al.  Increased plasma levels of endothelin-1 and urotensin-II in patients with coronary heart disease , 2010, Heart and Vessels.

[12]  Y. Tabara,et al.  Vasopressin V1a Receptor Polymorphism and Interval Walking Training Effects in Middle-Aged and Older People , 2010, Hypertension.

[13]  A. Stanton,et al.  Confirmation That the Renin Gene Distal Enhancer Polymorphism REN-5312C/T Is Associated With Increased Blood Pressure , 2010, Circulation. Cardiovascular genetics.

[14]  Kari Stefansson,et al.  Several common variants modulate heart rate, PR interval and QRS duration , 2010, Nature Genetics.

[15]  Mark N. Wass,et al.  Genetic variation in SCN10A influences cardiac conduction , 2010, Nature Genetics.

[16]  C. Ting,et al.  A genome-wide association study identifies new loci for ACE activity: potential implications for response to ACE inhibitor , 2010, The Pharmacogenomics Journal.

[17]  Christian Gieger,et al.  Genome-wide association study of PR interval , 2010, Nature Genetics.

[18]  L. Jorde,et al.  Genotype–phenotype analysis of angiotensinogen polymorphisms and essential hypertension: the importance of haplotypes , 2010, Journal of hypertension.

[19]  Susumu Goto,et al.  KEGG for representation and analysis of molecular networks involving diseases and drugs , 2009, Nucleic Acids Res..

[20]  A. Capasso,et al.  Migraine and coronary artery disease: an open study on the genetic polymorphism of the 5, 10 methylenetetrahydrofolate (MTHFR) and angiotensin I-converting enzyme (ACE) genes. , 2009, Central nervous system agents in medicinal chemistry.

[21]  Jessica L. Freeling,et al.  Specific subtypes of nicotinic cholinergic receptors involved in sympathetic and parasympathetic cardiovascular responses , 2009, Neuroscience Letters.

[22]  Barry Fine,et al.  Activation of the PI3K Pathway in Cancer Through Inhibition of PTEN by Exchange Factor P-REX2a , 2009, Science.

[23]  D. Arnett,et al.  Pharmacogenetics of antihypertensive treatment: detailing disciplinary dissonance. , 2009, Pharmacogenomics.

[24]  J. Witteman,et al.  A Genome-Wide Association Scan of RR and QT Interval Duration in 3 European Genetically Isolated Populations: The EUROSPAN Project , 2009, Circulation. Cardiovascular genetics.

[25]  Eric Boerwinkle,et al.  Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry , 2009, Nature Genetics.

[26]  G. Groothuis,et al.  Expression and regulation of the bile acid transporter, OSTα‐OSTβ in rat and human intestine and liver , 2009, Biopharmaceutics & drug disposition.

[27]  Charles Rotimi,et al.  A Genome-Wide Association Study of Hypertension and Blood Pressure in African Americans , 2009, PLoS genetics.

[28]  P. O’Reilly,et al.  Genome-wide association study identifies eight loci associated with blood pressure , 2009, Nature Genetics.

[29]  Andrew D. Johnson,et al.  Genome-wide association study of blood pressure and hypertension , 2009, Nature Genetics.

[30]  C. Ting,et al.  Genome-Wide Association Study of Young-Onset Hypertension in the Han Chinese Population of Taiwan , 2009, PloS one.

[31]  M. Daly,et al.  Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae. , 2009, Heart rhythm.

[32]  Taesung Park,et al.  A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits , 2009, Nature Genetics.

[33]  Thomas Lumley,et al.  Common variants at ten loci influence QT interval duration in the QTGEN Study , 2009, Nature Genetics.

[34]  Christian Gieger,et al.  Common variants at ten loci modulate the QT interval duration in the QTSCD Study , 2009, Nature Genetics.

[35]  Christian Gieger,et al.  Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations , 2009, Human molecular genetics.

[36]  Benjamin M. Neale,et al.  Genome-Wide Association Studies in an Isolated Founder Population from the Pacific Island of Kosrae , 2009, PLoS genetics.

[37]  Sanjiv J. Shah,et al.  Whole-genome association study identifies STK39 as a hypertension susceptibility gene , 2009, Proceedings of the National Academy of Sciences.

[38]  P. Binkley,et al.  Promoter Polymorphisms in ACE (Angiotensin I–Converting Enzyme) Associated With Clinical Outcomes in Hypertension , 2009, Clinical pharmacology and therapeutics.

[39]  C. Hoggart,et al.  Genome-wide association analysis of metabolic traits in a birth cohort from a founder population , 2008, Nature Genetics.

[40]  K. O’Shaughnessy,et al.  Both TASK-3 and TREK-1 two-pore loop K channels are expressed in H295R cells and modulate their membrane potential and aldosterone secretion. , 2008, American journal of physiology. Endocrinology and metabolism.

[41]  Toichiro Takizawa,et al.  Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone. , 2008, Kidney international.

[42]  C. Lewis,et al.  QTLs of factors of the metabolic syndrome and echocardiographic phenotypes: the hypertension genetic epidemiology network study , 2008, BMC Medical Genetics.

[43]  J. Blangero,et al.  Genetic variants in the renin-angiotensin system genes are associated with cardiovascular-renal-related risk factors in Mexican Americans , 2008, Human Genetics.

[44]  Brooke L. Fridley,et al.  Genomic Association Analysis Suggests Chromosome 12 Locus Influencing Antihypertensive Response to Thiazide Diuretic , 2008, Hypertension.

[45]  Y. Yatomi,et al.  Paradoxical mineralocorticoid receptor activation and left ventricular diastolic dysfunction under high oxidative stress conditions , 2008, Journal of hypertension.

[46]  Hongyu Zhao,et al.  Rare independent mutations in renal salt handling genes contribute to blood pressure variation , 2008, Nature Genetics.

[47]  T. Ogihara,et al.  Identification of Hypertension-Susceptibility Genes and Pathways by a Systemic Multiple Candidate Gene Approach: The Millennium Genome Project for Hypertension , 2008, Hypertension Research.

[48]  I. Borecki,et al.  Do inflammation and procoagulation biomarkers contribute to the metabolic syndrome cluster? , 2007, Nutrition & metabolism.

[49]  P. Lauf,et al.  K-Cl cotransport function and its potential contribution to cardiovascular disease. , 2007, Pathophysiology : the official journal of the International Society for Pathophysiology.

[50]  J. Baik,et al.  Functional Interaction of Neuronal Cav1.3 L-type Calcium Channel with Ryanodine Receptor Type 2 in the Rat Hippocampus* , 2007, Journal of Biological Chemistry.

[51]  Xiaoguang Sun,et al.  Regulation of RGS2 and Second Messenger Signaling in Vascular Smooth Muscle Cells by cGMP-dependent Protein Kinase* , 2007, Journal of Biological Chemistry.

[52]  D. Levy,et al.  Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study , 2007, BMC Medical Genetics.

[53]  Daniel Levy,et al.  Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness , 2007, BMC Medical Genetics.

[54]  Simon C. Potter,et al.  Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls , 2007, Nature.

[55]  Marcia M. Nizzari,et al.  Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels , 2007, Science.

[56]  D. Reich,et al.  Principal components analysis corrects for stratification in genome-wide association studies , 2006, Nature Genetics.

[57]  R. Rozen,et al.  Elevated Homocysteine Reduces Apolipoprotein A-I Expression in Hyperhomocysteinemic Mice and in Males With Coronary Artery Disease , 2006, Circulation research.

[58]  C. Dillon,et al.  Antihypertensive Medication Use Among US Adults With Hypertension , 2006, Circulation.

[59]  C. Kahn,et al.  Increased P85α Is a Potent Negative Regulator of Skeletal Muscle Insulin Signaling and Induces in Vivo Insulin Resistance Associated with Growth Hormone Excess* , 2005, Journal of Biological Chemistry.

[60]  J. Pankow,et al.  Quantitative trait loci for metabolic syndrome in the Hypertension Genetic Epidemiology Network study. , 2005, Obesity research.

[61]  A. Kraja,et al.  Two Major QTLs and Several Others Relate to Factors of Metabolic Syndrome in the Family Blood Pressure Program , 2005, Hypertension.

[62]  J. Albar,et al.  Direct interaction between the reductase domain of endothelial nitric oxide synthase and the ryanodine receptor , 2005, FEBS letters.

[63]  J. Pankow,et al.  An evaluation of the metabolic syndrome in the HyperGEN study , 2005, Nutrition & metabolism.

[64]  J. Pankow,et al.  Common variant of human NEDD4L activates a cryptic splice site to form a frameshifted transcript , 2002, Journal of Human Genetics.

[65]  Robert J. Unwin,et al.  Human Hypertension Caused by Mutations in WNK Kinases , 2001, Science.

[66]  P. Okin,et al.  Prognostic implications of left ventricular hypertrophy. , 2001, American heart journal.

[67]  Ali G. Gharavi,et al.  Molecular Mechanisms of Human Hypertension , 2001, Cell.

[68]  M A Province,et al.  NHLBI family blood pressure program: methodology and recruitment in the HyperGEN network. Hypertension genetic epidemiology network. , 2000, Annals of epidemiology.

[69]  N. Cook,et al.  Angiotensinogen genotype, sodium reduction, weight loss, and prevention of hypertension: trials of hypertension prevention, phase II. , 1998, Hypertension.

[70]  H. Margolius,et al.  Bradykinin B2 receptor antagonist increases chloride and water absorption in rat medullary collecting duct. , 1996, The American journal of physiology.

[71]  L. Schild,et al.  Identification of a PY motif in the epithelial Na channel subunits as a target sequence for mutations causing channel activation found in Liddle syndrome. , 1996, The EMBO journal.

[72]  Steven C. Hunt,et al.  Molecular basis of human hypertension: Role of angiotensinogen , 1992, Cell.

[73]  R. Collins,et al.  Blood pressure, stroke, and coronary heart disease Part 2, short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context , 1990, The Lancet.

[74]  R. Collins,et al.  Blood pressure, stroke, and coronary heart disease Part 1, prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias , 1990, The Lancet.

[75]  J. Stockman.  Genetic Variants Associated With Cardiac Structure and Function: A Meta-analysis and Replication of Genome-wide Association Data , 2011 .

[76]  W. Elliott.  US Trends in Prevalence, Awareness, Treatment, and Control of Hypertension, 1988-2008 , 2011 .

[77]  K. Mossman.  The Wellcome Trust Case Control Consortium, U.K. , 2008 .

[78]  S. Easthope,et al.  Candesartan cilexetil: an update of its use in essential hypertension. , 2002, Drugs.