The warrior in the machine: neuroscience goes to war

Ever since Stone Age men discovered that knapping flint produced sharp stone edges that could be used in combat as well as for cooking and hunting, technological advances of all kinds have been adapted and adopted by the military.The opportunities provided by modern neuroscience are proving no exception, but their application in a military context is accompanied by complex practical and ethical considerations.

[1]  E. Holmes,et al.  Assessing mental imagery in clinical psychology: A review of imagery measures and a guiding framework , 2013, Clinical psychology review.

[2]  J. Bailes,et al.  Neuroprotection for the warrior: dietary supplementation with omega-3 fatty acids. , 2011, Military medicine.

[3]  Kimberly R. Aspinwall,et al.  2008 Department of Defense Survey of Health Related Behaviors Among Active Duty Military Personnel A Component of the Defense Lifestyle Assessment Program (DLAP) , 2008 .

[4]  B. Ehrenreich,et al.  Blood Rites: Origins and History of the Passions of War , 1997 .

[5]  Peter Tikuisis,et al.  Acute caffeine intake before and after fatiguing exercise improves target shooting engagement time. , 2004, Aviation, space, and environmental medicine.

[6]  P. Schlattmann,et al.  Modafinil and methylphenidate for neuroenhancement in healthy individuals: A systematic review. , 2010, Pharmacological research.

[7]  K. Olkkola,et al.  Enhancement of GABAergic Activity: Neuropharmacological Effects of Benzodiazepines and Therapeutic Use in Anesthesiology , 2011, Pharmacological Reviews.

[8]  N. Rasmussen.  Medical Science and the Military: The Allies' Use of Amphetamine during World War II , 2011, Journal of Interdisciplinary History.

[9]  Jiří Horáček,et al.  Psilocybin – Summary of knowledge and new perspectives , 2014, European Neuropsychopharmacology.

[10]  M. Minzenberg,et al.  Modafinil: A Review of Neurochemical Actions and Effects on Cognition , 2008, Neuropsychopharmacology.

[11]  Matthew W. Johnson,et al.  Mystical experiences occasioned by the hallucinogen psilocybin lead to increases in the personality domain of openness , 2011, Journal of psychopharmacology.

[12]  Bruce Luber,et al.  Enhancement of human cognitive performance using transcranial magnetic stimulation (TMS) , 2014, NeuroImage.

[13]  Tim Dalgleish,et al.  Ameliorating intrusive memories of distressing experiences using computerized reappraisal training. , 2012, Emotion.

[14]  S. Zhang,et al.  Profiles of psychiatric symptoms among amphetamine type stimulant and ketamine using inpatients in Wuhan, China. , 2014, Journal of psychiatric research.

[15]  R. Gable.  Comparison of acute lethal toxicity of commonly abused psychoactive substances. , 2004, Addiction.

[16]  J. Baranski,et al.  Self‐monitoring cognitive performance during sleep deprivation: effects of modafinil, d‐amphetamine and placebo , 2003, Journal of sleep research.

[17]  J. Lakoski,et al.  Preface to the Report: The Advantages and Limitations of Calmatives for Use as a Non-Lethal Technique , 2002 .

[18]  Tsung-Min Hung,et al.  Electroencephalographic Studies of Skilled Psychomotor Performance , 2004, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[19]  R. C. Kadosh.  Using transcranial electrical stimulation to enhance cognitive functions in the typical and atypical brain , 2013 .

[20]  P. Wax,et al.  Unexpected "gas" casualties in Moscow: a medical toxicology perspective. , 2003, Annals of emergency medicine.

[21]  Kevin Warwick,et al.  Novel Neurotechnologies: Intervening in the Brain , 2013 .

[22]  D. Aldington.  Pain management in victims of conflict , 2012, Current opinion in supportive and palliative care.

[23]  U. Frith,et al.  Neuroscience: implications for education and lifelong learning , 2013 .

[24]  Michael E. Smith,et al.  Monitoring Task Loading with Multivariate EEG Measures during Complex Forms of Human-Computer Interaction , 2001, Hum. Factors.

[25]  Johan Wessberg,et al.  In touch with your emotions: Oxytocin and touch change social impressions while others’ facial expressions can alter touch , 2014, Psychoneuroendocrinology.

[26]  C. Hillman,et al.  Cortico-cortical communication and superior performance in skilled marksmen: an EEG coherence analysis. , 2003 .

[27]  Neil Davison.  'Non-Lethal' Weapons , 2009 .

[28]  C. Piérard,et al.  Prior sleep with zolpidem enhances the effect of caffeine or modafinil during 18 hours continuous work. , 2006, Aviation, space, and environmental medicine.

[29]  M. Arns,et al.  Golf performance enhancement and real-life neurofeedback training using personalized event-locked EEG profiles , 2008 .

[30]  P. Zak,et al.  Oxytocin is associated with human trustworthiness , 2005, Hormones and Behavior.

[31]  A. Maelicke,et al.  Modulation of Nicotinic Receptor Activity in the Central Nervous System: A Novel Approach to the Treatment of Alzheimer Disease , 2001, Alzheimer disease and associated disorders.

[32]  T. Robbins,et al.  Brain science, addiction and drugs , 2010 .

[33]  S. Noar,et al.  Nonmedical ADHD stimulant use in fraternities. , 2009, Journal of studies on alcohol and drugs.

[34]  Vince D. Calhoun,et al.  TDCS guided using fMRI significantly accelerates learning to identify concealed objects , 2012, NeuroImage.

[35]  Hannah Hoag.  Neuroengineering: Remote control , 2003, Nature.

[36]  E. Brown,et al.  General anesthesia and altered states of arousal: a systems neuroscience analysis. , 2011, Annual review of neuroscience.

[37]  Gavin Kilpatrick,et al.  CNS 7056: A Novel Ultra–short-acting Benzodiazepine , 2007, Anesthesiology.

[38]  B. Shukitt-Hale,et al.  Effects of caffeine, sleep loss, and stress on cognitive performance and mood during U.S. Navy SEAL training , 2002, Psychopharmacology.

[39]  Richard H. Dees.  Cosmetic neurology: the controversy over enhancing movement, mentation, and mood. , 2005, Neurology.

[40]  G. Ryle,et al.  心的概念 = The concept of mind , 1962 .

[41]  Madeleine P Strohl.  Bradley’s Benzedrine Studies on Children with Behavioral Disorders , 2011, The Yale journal of biology and medicine.

[42]  J. Gallant,et al.  Reconstructing Visual Experiences from Brain Activity Evoked by Natural Movies , 2011, Current Biology.

[43]  J. Moreno,et al.  Neuroscience, Ethics, and National Security: The State of the Art , 2012, PLoS biology.

[44]  J. Moreno.  Mind Wars: Brain Research and National Defense , 2006, Learning To Live Together: Promoting Social Harmony.

[45]  C. Marmar,et al.  Immediate treatment with propranolol decreases posttraumatic stress disorder two months after trauma , 2003, Biological Psychiatry.

[46]  S. Rose.  A Faustian bargain? , 2011, EMBO reports.

[47]  Hyuk Oh,et al.  Cerebral cortical dynamics during visuomotor transformation: adaptation to a cognitive-motor executive challenge. , 2011, Psychophysiology.

[48]  James L. McGaugh,et al.  β-Adrenergic activation and memory for emotional events , 1994, Nature.

[49]  J. Brunelin,et al.  Non-invasive brain stimulation can induce paradoxical facilitation. Are these neuroenhancements transferable and meaningful to security services? , 2013, Front. Hum. Neurosci..

[50]  R. Malenka,et al.  Social reward requires coordinated activity of accumbens oxytocin and 5HT , 2013, Nature.

[51]  K. Nader,et al.  Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval , 2000, Nature.

[52]  Michael J. Black,et al.  Neural control of cursor trajectory and click by a human with tetraplegia 1000 days after implant of an intracortical microelectrode array , 2011 .

[53]  Patrick Ragert,et al.  Why non-invasive brain stimulation should not be used in military and security services , 2013, Front. Hum. Neurosci..

[54]  Timothy E. J. Behrens,et al.  Choice, uncertainty and value in prefrontal and cingulate cortex , 2008, Nature Neuroscience.

[55]  S. Yeghiayan,et al.  Beneficial Effects of a Protein Free, High Carbohydrate Meal on Rat Coping Behavior and Neurotransmitter Levels During Heat Stress , 2004, Nutritional neuroscience.

[56]  Ruth O'Hara,et al.  Psychoactive Drugs and Pilot Performance: A Comparison of Nicotine, Donepezil, and Alcohol Effects , 2003, Neuropsychopharmacology.

[57]  M. Dobbs.  Clinical Neurotoxicology: Syndromes, Substances, Environments , 2009 .

[58]  R. Bolles,et al.  Role of conditioned contextual stimuli in reinstatement of extinguished fear. , 1979, Journal of experimental psychology. Animal behavior processes.

[59]  Fred J Helmstetter,et al.  Long‐term stability of fear memory depends on the synthesis of protein but not mRNA in the amygdala , 2006, The European journal of neuroscience.

[60]  R A Folen,et al.  Autogenic Feedback Training Exercise and Pilot Performance: Enhanced Functioning Under Search-and-Rescue Flying Conditions , 2001, The International journal of aviation psychology.

[61]  R. Défalque,et al.  Methamphetamine for Hitler's Germany: 1937 to 1945. , 2011, Bulletin of anesthesia history.

[62]  L. Hourani,et al.  2005 Department of Defense Survey of Health Related Behaviors among Active Duty Military Personnel , 2006 .

[63]  R. Berry,et al.  Sleep and Military Members: Emerging Issues and Nonpharmacological Intervention , 2013, Sleep disorders.

[64]  L. Wolpert.  Is science dangerous? , 1999, Nature.

[65]  S. Rose.  'Smart Drugs': do they work? Are they ethical? Will they be legal? , 2002, Nature Reviews Neuroscience.

[66]  Stephen Maren,et al.  Seeking a Spotless Mind: Extinction, Deconsolidation, and Erasure of Fear Memory , 2011, Neuron.

[67]  C. Timperley,et al.  Analysis of clothing and urine from Moscow theatre siege casualties reveals carfentanil and remifentanil use. , 2012, Journal of analytical toxicology.

[68]  Rodolphe J. Gentili.  Non-invasive Functional Brain Biomarkers for Cognitive-Motor Performance Assessment: Towards New Brain Monitoring Applications , 2011, HCI.

[69]  G. C. Giam.  Effects of sleep deprivation with reference to military operations. , 1997, Annals of the Academy of Medicine, Singapore.

[70]  John D E Gabrieli,et al.  Control over brain activation and pain learned by using real-time functional MRI. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[71]  B. Sahakian,et al.  The Effects of Nicotine on Attention, Information Processing, and Short-Term Memory in Patients with Dementia of the Alzheimer Type , 1989, British Journal of Psychiatry.

[72]  J. Yesavage,et al.  Donepezil and flight simulator performance: Effects on retention of complex skills , 2002, Neurology.

[73]  J. Fishman,et al.  Propranolol and the Prevention of Post-Traumatic Stress Disorder: Is it Wrong to Erase the “Sting” of Bad Memories? , 2007, American Journal of Bioethics.

[74]  T. Robbins,et al.  Decision-making processes following damage to the prefrontal cortex. , 2002, Brain : a journal of neurology.

[75]  R. Richardson,et al.  d-cycloserine facilitates extinction of learned fear: Effects on reacquisition and generalized extinction , 2005, Biological Psychiatry.

[76]  Jun Lu,et al.  The &agr;2-Adrenoceptor Agonist Dexmedetomidine Converges on an Endogenous Sleep-promoting Pathway to Exert Its Sedative Effects , 2003, Anesthesiology.

[77]  U. Schnyder,et al.  A randomized, controlled pilot study of MDMA (±3,4-Methylenedioxymethamphetamine)-assisted psychotherapy for treatment of resistant, chronic Post-Traumatic Stress Disorder (PTSD) , 2013, Journal of psychopharmacology.

[78]  S. Cooper,et al.  Remote Control , 2002, Nursing standard (Royal College of Nursing (Great Britain) : 1987).

[79]  B. Maher,et al.  Poll results: look who's doping , 2008, Nature.

[80]  D. Picchioni,et al.  Caffeine Gum Minimizes Sleep Inertia , 2013, Perceptual and motor skills.

[81]  B. Weiss,et al.  Enhancement of human performance by caffeine and the amphetamines. , 1962, Pharmacological reviews.

[82]  Douglas Fox,et al.  Neuroscience: Brain buzz , 2011, Nature.

[83]  M. Stein,et al.  Pharmacotherapy to prevent PTSD: Results from a randomized controlled proof-of-concept trial in physically injured patients. , 2007, Journal of traumatic stress.

[84]  T. Elbert,et al.  The downside of strong emotional memories: How human memory-related genes influence the risk for posttraumatic stress disorder – A selective review , 2014, Neurobiology of Learning and Memory.

[85]  John A. Caidwell,et al.  The Effects of Modafinil on Aviator Performance During 40 Hours of Continuous Wakefulness: A UH-60 Helicopter Simulator Study , 1999 .

[86]  J. Brunelin,et al.  Is it ethical and safe to use non-invasive brain stimulation as a cognitive and motor enhancer device for military services? A reply to Sehm and Ragert (2013) , 2013, Front. Hum. Neurosci..

[87]  G. Cocks.  Psychotherapy in the Third Reich , 2012 .

[88]  M. Wheelis,et al.  Neurobiology: A case study of the imminent militarization of biology , 2005, International Review of the Red Cross.

[89]  R. Cohen Kadosh,et al.  The regulation of cognitive enhancement devices: refining Maslen et al.'s model , 2015, Journal of law and the biosciences.

[90]  B. Hatfield,et al.  Cerebral cortical adaptations associated with visuomotor practice. , 2004, Medicine and science in sports and exercise.

[91]  J. Davidson.  Pharmacologic treatment of acute and chronic stress following trauma: 2006. , 2006, The Journal of clinical psychiatry.

[92]  S.L. Rogers,et al.  Perspectives in the Management of Alzheimer’s Disease: Clinical Profile of Donepezil , 1998, Dementia and Geriatric Cognitive Disorders.

[93]  U. Fischbacher,et al.  Oxytocin increases trust in humans , 2005, Nature.

[94]  Scott B. MacKenzie,et al.  Sources of Method Bias in Social Science Research and Recommendations on How to Control It , 2012 .

[95]  J Lynn Caldwell,et al.  Fatigue in military aviation: an overview of US military-approved pharmacological countermeasures. , 2005, Aviation, space, and environmental medicine.

[96]  Scott T. Grafton,et al.  Dynamic reconfiguration of human brain networks during learning , 2010, Proceedings of the National Academy of Sciences.

[97]  James David,et al.  Remote Control , 2008 .

[98]  Walter Paulus,et al.  Facilitation of probabilistic classification learning by transcranial direct current stimulation of the prefrontal cortex in the human , 2004, Neuropsychologia.

[99]  John Caldwell,et al.  Stimulant Use in Extended Flight Operations , 1998 .

[100]  Luke Clark,et al.  The contributions of lesion laterality and lesion volume to decision-making impairment following frontal lobe damage , 2003, Neuropsychologia.

[101]  A. Chatterjee.  Cosmetic neurology , 2004, Neurology.

[102]  Nicholas G Hatsopoulos,et al.  The science of neural interface systems. , 2009, Annual review of neuroscience.

[103]  S J Petruzzello,et al.  The influence of electrocortical biofeedback on performance in pre-elite archers. , 1991, Medicine and science in sports and exercise.

[104]  O. Hardt,et al.  A single standard for memory: the case for reconsolidation , 2009, Nature Reviews Neuroscience.

[105]  Michael K Parides,et al.  Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial. , 2014, JAMA psychiatry.

[106]  C. Berridge.  Noradrenergic modulation of arousal , 2008, Brain Research Reviews.

[107]  B. Fredholm,et al.  Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. , 1999, Pharmacological reviews.

[108]  Richard Gonzalez,et al.  Common Consequence Conditions in Decision Making under Risk , 1998 .

[109]  James V. Haxby,et al.  Multivariate pattern analysis of fMRI: The early beginnings , 2012, NeuroImage.

[110]  Phillip B Sparling.  The Lance Armstrong saga: a wake-up call for drug reform in sports. , 2013, Current sports medicine reports.

[111]  George I. Christopoulos,et al.  Risk-dependent reward value signal in human prefrontal cortex , 2009, Proceedings of the National Academy of Sciences.

[112]  J. Miró,et al.  Neuromodulatory treatments for chronic pain: efficacy and mechanisms , 2014, Nature Reviews Neurology.

[113]  M. Dando.  Advances in Neuroscience and the Biological and Toxin Weapons Convention , 2010, Biotechnology research international.

[114]  B. Sahakian,et al.  Professor's little helper , 2007, Nature.

[115]  L. Cahill,et al.  Pilot study of secondary prevention of posttraumatic stress disorder with propranolol , 2002, Biological Psychiatry.