Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3

[1]  Jing Xu,et al.  Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines , 2018, Journal of Extracellular Vesicles.

[2]  A. O’Loghlen Role for extracellular vesicles in the tumour microenvironment , 2017, Philosophical Transactions of the Royal Society B: Biological Sciences.

[3]  K. Kaestner,et al.  Cytoplasmic chromatin triggers inflammation in senescence and cancer , 2017, Nature.

[4]  M. Henry,et al.  Protein and chemotherapy profiling of extracellular vesicles harvested from therapeutic induced senescent triple negative breast cancer cells , 2017, Oncogenesis.

[5]  L. Zender,et al.  Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence , 2017, Nature Cell Biology.

[6]  E. Hara,et al.  Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2 , 2017, Nature Communications.

[7]  Shenghui He,et al.  Senescence in Health and Disease , 2017, Cell.

[8]  Zhijian J. Chen,et al.  cGAS is essential for cellular senescence , 2017, Proceedings of the National Academy of Sciences.

[9]  K. Nagao,et al.  Exosomes maintain cellular homeostasis by excreting harmful DNA from cells , 2017, Nature Communications.

[10]  Raghu Kalluri,et al.  Exosomes Facilitate Therapeutic Targeting of Oncogenic Kras in Pancreatic Cancer , 2017, Nature.

[11]  M. Borghesan,et al.  Integrin Beta 3 Regulates Cellular Senescence by Activating the TGF-β Pathway , 2017, Cell reports.

[12]  A. Oberg,et al.  Cellular senescence mediates fibrotic pulmonary disease , 2017, Nature Communications.

[13]  B. Kennedy,et al.  Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse. , 2017, Cancer discovery.

[14]  C. R. Esteban,et al.  In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming , 2016, Cell.

[15]  M. Blasco,et al.  Tissue damage and senescence provide critical signals for cellular reprogramming in vivo , 2016, Science.

[16]  Masashi Narita,et al.  NOTCH1 mediates a switch between two distinct secretomes during senescence , 2016, Nature Cell Biology.

[17]  Clotilde Théry,et al.  Communication by Extracellular Vesicles: Where We Are and Where We Need to Go , 2016, Cell.

[18]  A. Klochendler,et al.  p16Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion , 2016, Nature Medicine.

[19]  J. Rheenen,et al.  Studying extracellular vesicle transfer by a Cre-loxP method , 2015, Nature Protocols.

[20]  Gary K. Schwartz,et al.  Tumour exosome integrins determine organotropic metastasis , 2015, Nature.

[21]  L. Zender,et al.  mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype , 2015, Nature Cell Biology.

[22]  Christian Pilarsky,et al.  Glypican-1 identifies cancer exosomes and detects early pancreatic cancer , 2015, Nature.

[23]  P. Nelson,et al.  MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation , 2015, Nature Cell Biology.

[24]  Jacco van Rheenen,et al.  In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior , 2015, Cell.

[25]  C. Lengner,et al.  DNA-damage-induced type I interferon promotes senescence and inhibits stem cell function. , 2015, Cell reports.

[26]  Simona Parrinello,et al.  The nuclear receptor NR2E1/TLX controls senescence , 2014, Oncogene.

[27]  Anton J. Enright,et al.  Extracellular vesicles from neural stem cells transfer IFN-γ via Ifngr1 to activate Stat1 signaling in target cells. , 2014, Molecular cell.

[28]  Manuel Serrano,et al.  Cellular senescence: from physiology to pathology , 2014, Nature Reviews Molecular Cell Biology.

[29]  M. Narita,et al.  Cellular senescence and its effector programs , 2014, Genes & development.

[30]  Jiangxia Liu,et al.  Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity , 2013, Nature Immunology.

[31]  Kelly J. Morris,et al.  A complex secretory program orchestrated by the inflammasome controls paracrine senescence , 2013, Nature Cell Biology.

[32]  Darjus F. Tschaharganeh,et al.  Non-Cell-Autonomous Tumor Suppression by p53 , 2013, Cell.

[33]  C. Lawless,et al.  A senescent cell bystander effect: senescence-induced senescence , 2012, Aging cell.

[34]  R. Hruban,et al.  Cellular features of senescence during the evolution of human and murine ductal pancreatic cancer , 2012, Oncogene.

[35]  A. Brass,et al.  Distinct Patterns of IFITM-Mediated Restriction of Filoviruses, SARS Coronavirus, and Influenza A Virus , 2011, PLoS pathogens.

[36]  Paul Timpson,et al.  Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer , 2010, Proceedings of the National Academy of Sciences.

[37]  Miguel C. Seabra,et al.  Rab27a and Rab27b control different steps of the exosome secretion pathway , 2010, Nature Cell Biology.

[38]  D. Peeper,et al.  Senescence-messaging secretome: SMS-ing cellular stress , 2009, Nature Reviews Cancer.

[39]  S. Lowe,et al.  Senescence of Activated Stellate Cells Limits Liver Fibrosis , 2008, Cell.

[40]  D. Terrian,et al.  Senescence-associated exosome release from human prostate cancer cells. , 2008, Cancer research.

[41]  Jonathan Melamed,et al.  Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence , 2008, Cell.

[42]  D. Peeper,et al.  Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network , 2008, Cell.

[43]  Petra Schwille,et al.  Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes , 2008, Science.

[44]  Yusuf A. Hannun,et al.  Principles of bioactive lipid signalling: lessons from sphingolipids , 2008, Nature Reviews Molecular Cell Biology.

[45]  Aled Clayton,et al.  Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids , 2006, Current protocols in cell biology.

[46]  E. Petricoin,et al.  Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. , 2003, Cancer cell.