Fully Automating Graf's Method for DDH Diagnosis Using Deep Convolutional Neural Networks

Developmental dysplasia of the hip (DDH) is a condition affecting up to 1 in 30 infants. DDH is easy to treat if diagnosed early, but undiagnosed DDH can result in life-long hip pain, dysfunction and an increased risk of early onset osteoarthritis, and accounts for around 30 % of all hip replacements in patients under 60. The gold standard for diagnosis in infants is an ultrasound scan, followed by an analysis procedure known as Graf’s method. The application of Graf’s method is notoriously operator-dependent, requiring years of training to reach reasonable and reproducible performance. We describe a novel deep-learning based pipeline that applies Graf’s method to ultrasound scans of the hip. We use a convolutional network with an adversarial component to segment the image into relevant landmarks, and define a set of post-processing rules to translate the segmentations into Graf’s metrics. Comparing our pipeline to estimates made by experts in DDH diagnosis shows promising results.

[1]  J J Dias,et al.  The reliability of ultrasonographic assessment of neonatal hips. , 1993, The Journal of bone and joint surgery. British volume.

[2]  Christopher Joseph Pal,et al.  Brain tumor segmentation with Deep Neural Networks , 2015, Medical Image Anal..

[3]  G. Zielhuis,et al.  Ultrasonographic screening for developmental dysplasia of the hip in infants. Reproducibility of assessments made by radiographers. , 2003, The Journal of bone and joint surgery. British volume.

[4]  R. Graf,et al.  The diagnosis of congenital hip-joint dislocation by the ultrasonic combound treatment , 2004, Archives of orthopaedic and traumatic surgery.

[5]  M. Zieger,et al.  Ultrasound of the infant hip. Part 2. Validity of the method , 1987, Pediatric Radiology.

[6]  Soumith Chintala,et al.  Unsupervised Representation Learning with Deep Convolutional Generative Adversarial Networks , 2015, ICLR.

[7]  Geoffrey E. Hinton,et al.  ImageNet classification with deep convolutional neural networks , 2012, Commun. ACM.

[8]  Hasan Erdinc Kocer,et al.  Segmentation of the Ilium and Femur Regions from Ultrasound Images for Diagnosis of Developmental Dysplasia of the Hip , 2016 .

[9]  Jimmy Ba,et al.  Adam: A Method for Stochastic Optimization , 2014, ICLR.

[10]  Jitendra Malik,et al.  Hypercolumns for object segmentation and fine-grained localization , 2014, 2015 IEEE Conference on Computer Vision and Pattern Recognition (CVPR).

[11]  Shuiwang Ji,et al.  Deep convolutional neural networks for multi-modality isointense infant brain image segmentation , 2015, NeuroImage.

[12]  Martín Abadi,et al.  TensorFlow: Large-Scale Machine Learning on Heterogeneous Distributed Systems , 2016, ArXiv.

[13]  Sergey Ioffe,et al.  Batch Normalization: Accelerating Deep Network Training by Reducing Internal Covariate Shift , 2015, ICML.

[14]  Geoffrey E. Hinton,et al.  Deep Learning , 2015, Nature.

[15]  Jia Deng,et al.  Stacked Hourglass Networks for Human Pose Estimation , 2016, ECCV.

[16]  Emmanuelle Gouillart,et al.  scikit-image: image processing in Python , 2014, PeerJ.

[17]  B. Espehaug,et al.  Hip disease and the prognosis of total hip replacements. A review of 53,698 primary total hip replacements reported to the Norwegian Arthroplasty Register 1987-99. , 2001, The Journal of bone and joint surgery. British volume.

[18]  Jian Sun,et al.  Delving Deep into Rectifiers: Surpassing Human-Level Performance on ImageNet Classification , 2015, 2015 IEEE International Conference on Computer Vision (ICCV).