Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation The Task Force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology ( ESC )

Authors/Task Force Members: Ph. Gabriel Steg (Chairperson) (France)*, Stefan K. James (Chairperson) (Sweden)*, Dan Atar (Norway), Luigi P. Badano (Italy), Carina Blömstrom-Lundqvist (Sweden), Michael A. Borger (Germany), Carlo Di Mario (United Kingdom), Kenneth Dickstein (Norway), Gregory Ducrocq (France), Francisco Fernandez-Aviles (Spain), Anthony H. Gershlick (United Kingdom), Pantaleo Giannuzzi (Italy), Sigrun Halvorsen (Norway), Kurt Huber (Austria), Peter Juni (Switzerland), Adnan Kastrati (Germany), Juhani Knuuti (Finland), Mattie J. Lenzen (Netherlands), Kenneth W. Mahaffey (USA), Marco Valgimigli (Italy), Arnoud van ’t Hof (Netherlands), Petr Widimsky (Czech Republic), Doron Zahger (Israel)

K. Mahaffey | A. Budaj | J. Knuuti | M. Borger | M. Valgimigli | M. Lenzen | A. Gershlick | S. James | S. Halvorsen | A. Fuat | D. Hasdai | L. Badano | F. Astin | O. Gustienė | F. Piepoli | Stefan K. James Chairperson | Dan Atar Norway | Lars Wallentin Sweden | U. Sechtem | V. Dean | R. Fagard | Arno W. Hoes | Helmut Baumgartner | Paulus Kirchhof | Bogdan A. Popescu | Peter M. Clemmensen | D. Norway | Stephan Windecker | Claudio Ceconi | J. Germany | Keith A Fox | Philippe H. Kolh | Kenneth Dickstein | D. Atar | P. Steg | Francisco Fernández-Avilés | Christi Deaton | Chairperson | France | Italy | Task Force | Ph Gabriel | Steg Chairperson | Sweden | Luigi P Norway | Carina Badano | Sweden Blö Mstrom-Lundqvist | Carlo Germany | Mario Di | Gregory Norway | France Ducrocq | Anthony H Spain | Pantaleo Gershlick | Giannuzzi | Sigrun Italy | Halvorsen | Kurt Norway | Peter Huber | Adnan Juni | Kastrati | M. J. Knuuti | Kenneth W Lenzen | Mahaffey | Arnoud Italy | Petr Van 't Hof | Doron Widimsky | Israel Zahger | J. Bax | Christian Belgium | France Funck-Brentano | Israel | Germany Uk | Theresa Belgium | Cyril Mcdonagh | France Moulin | Anton Germany | Sirnes | Michal Norway | Adam Tendera | Alec Torbicki | France Vahanian | Karin A Strö M-Olsson | Jean-Philippe Denmark | France Collet | Christian W Lithuania | Petr Hamm | Czech Kala | Patrizio Replublic | Lancellotti | Aldo Pietro Belgium | Maggioni | La Bé | Franz-Josef Merkely | Neumann | Massimo F Germany | Van De Werf | Freek Belgium | Lars Verheugt | Sweden Wallentin | Stefan K. James Chairperson | D. Norway | Lars Wallentin Sweden | A. Gershlick

[1]  O. Alfieri,et al.  Guidelines on the management of valvular heart disease. , 2007, European heart journal.

[2]  C. Cannon,et al.  Response to Letter Regarding Article, “Association of Proton Pump Inhibitor Use on Cardiovascular Outcomes With Clopidogrel and Ticagrelor: Insights From PLATO” , 2012 .

[3]  G. Stone,et al.  Intracoronary abciximab and aspiration thrombectomy in patients with large anterior myocardial infarction: the INFUSE-AMI randomized trial. , 2012, JAMA.

[4]  G. Stone,et al.  Drug-eluting vs bare-metal stents in primary angioplasty: a pooled patient-level meta-analysis of randomized trials. , 2012, Archives of internal medicine.

[5]  Yuling Hong,et al.  Age-specific gender differences in in-hospital mortality by type of acute myocardial infarction. , 2012, The American journal of cardiology.

[6]  M. Jeong,et al.  Sex differences in management and mortality of patients with ST-elevation myocardial infarction (from the Korean Acute Myocardial Infarction National Registry). , 2012, The American journal of cardiology.

[7]  G. Schuler,et al.  Intracoronary versus intravenous bolus abciximab during primary percutaneous coronary intervention in patients with acute ST-elevation myocardial infarction: a randomised trial , 2012, The Lancet.

[8]  Sarabjeet Singh,et al.  Cardiovascular Outcomes Using Intra-Aortic Balloon Pump in High-Risk Acute Myocardial Infarction With or Without Cardiogenic Shock , 2012, Journal of cardiovascular pharmacology and therapeutics.

[9]  J. Tijssen,et al.  Comparison of drug-eluting and bare-metal stents for primary percutaneous coronary intervention with or without abciximab in ST-segment elevation myocardial infarction: DEBATER: the Eindhoven reperfusion study. , 2012, JACC. Cardiovascular interventions.

[10]  E. Vicaut,et al.  Efficacy and safety of enoxaparin versus unfractionated heparin during percutaneous coronary intervention: systematic review and meta-analysis , 2012, BMJ : British Medical Journal.

[11]  Omeed Saghafi.  Intra-aortic Balloon Counterpulsation and Infarct Size in Patients with Acute Anterior Myocardial Infarction without Shock: The CRISP AMI Randomized Trial , 2012 .

[12]  W. Gibler,et al.  Ground emergency medical services requests for helicopter transfer of ST-segment elevation myocardial infarction patients decrease medical contact to balloon times in rural and suburban settings. , 2012, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[13]  M. Price,et al.  Bridging antiplatelet therapy with cangrelor in patients undergoing cardiac surgery: a randomized controlled trial. , 2012, JAMA.

[14]  Paul Burton,et al.  Rivaroxaban in patients with a recent acute coronary syndrome. , 2012, The New England journal of medicine.

[15]  D. Mozaffarian,et al.  Executive summary: heart disease and stroke statistics--2012 update: a report from the American Heart Association. , 2012, Circulation.

[16]  A. Henderson,et al.  Rehabilitation after myocardial infarction trial (RAMIT): multi-centre randomised controlled trial of comprehensive cardiac rehabilitation in patients following acute myocardial infarction , 2011, Heart.

[17]  Byung Ok Kim,et al.  Six-Month versus Twelve-Month Dual Antiplatelet Therapy after Implantation of Drug-Eluting Stents: 'EXCELLENT' Randomized, Multicenter Study , 2011 .

[18]  D. Dudek,et al.  Early glycoprotein IIb‐IIIa inhibitors in primary angioplasty‐abciximab long‐term results (EGYPT‐ALT) cooperation: individual patient’s data meta‐analysis , 2011, Journal of thrombosis and haemostasis : JTH.

[19]  C. Cannon,et al.  Characterization of dyspnoea in PLATO study patients treated with ticagrelor or clopidogrel and its association with clinical outcomes. , 2011, European heart journal.

[20]  R. de Caterina,et al.  Antiplatelet agents for the treatment and prevention of atherothrombosis. , 2011, European heart journal.

[21]  J. Smith,et al.  Effect of upstream clopidogrel treatment in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. , 2011, European heart journal.

[22]  F. Van de Werf,et al.  Dabigatran vs. placebo in patients with acute coronary syndromes on dual antiplatelet therapy: a randomized, double-blind, phase II trial. , 2011, European heart journal.

[23]  A. Shimony,et al.  Meta-analysis of randomized controlled trials of intracoronary versus intravenous administration of glycoprotein IIb/IIIa inhibitors during percutaneous coronary intervention for acute coronary syndrome. , 2011, The American journal of cardiology.

[24]  M. Dzingina,et al.  Hyperglycaemia in acute coronary syndromes: summary of NICE guidance , 2011, BMJ : British Medical Journal.

[25]  D. Roberts,et al.  The ability to achieve complete revascularization is associated with improved in‐hospital survival in cardiogenic shock due to myocardial infarction: Manitoba cardiogenic shock registry investigators , 2011, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.

[26]  Deepak L. Bhatt,et al.  Antithrombotic Therapy in Patients With Atrial Fibrillation Undergoing Coronary Stenting: A North American Perspective: Executive Summary , 2011, Circulation. Cardiovascular interventions.

[27]  K. Filion,et al.  Efficacy of exercise-based cardiac rehabilitation post-myocardial infarction: a systematic review and meta-analysis of randomized controlled trials. , 2011, American heart journal.

[28]  S. de Servi,et al.  Low‐molecular‐weight heparins vs. unfractionated heparin in the setting of percutaneous coronary intervention for ST‐elevation myocardial infarction: a meta‐analysis , 2011, Journal of thrombosis and haemostasis : JTH.

[29]  H. Schuchlenz,et al.  Clopidogrel pre-treatment is associated with reduced in-hospital mortality in primary percutaneous coronary intervention for acute ST-elevation myocardial infarction. , 2011, European heart journal.

[30]  P. Armstrong,et al.  Diagnosing acute myocardial infarction in patients with left bundle branch block. , 2011, The American journal of cardiology.

[31]  C. Terkelsen,et al.  System delay and timing of intervention in acute myocardial infarction (from the Danish Acute Myocardial Infarction-2 [DANAMI-2] trial). , 2011, The American journal of cardiology.

[32]  O. Hlinomaz,et al.  Primary angioplasty in acute myocardial infarction with right bundle branch block: should new onset right bundle branch block be added to future guidelines as an indication for reperfusion therapy? , 2011, European heart journal.

[33]  G. Lip,et al.  RUBY-1: a randomized, double-blind, placebo-controlled trial of the safety and tolerability of the novel oral factor Xa inhibitor darexaban (YM150) following acute coronary syndrome , 2011, European heart journal.

[34]  Deepak L. Bhatt,et al.  Apixaban with antiplatelet therapy after acute coronary syndrome. , 2011, The New England journal of medicine.

[35]  E. Vicaut,et al.  Intravenous enoxaparin or unfractionated heparin in primary percutaneous coronary intervention for ST-elevation myocardial infarction: the international randomised open-label ATOLL trial , 2011, The Lancet.

[36]  D. Holmes,et al.  Clinical ResearchInterventional CardiologyCulprit Vessel Only Versus Multivessel and Staged Percutaneous Coronary Intervention for Multivessel Disease in Patients Presenting With ST-Segment Elevation Myocardial Infarction: A Pairwise and Network Meta-Analysis , 2011 .

[37]  B. Gersh,et al.  Prognostic impact of staged versus "one-time" multivessel percutaneous intervention in acute myocardial infarction: analysis from the HORIZONS-AMI (harmonizing outcomes with revascularization and stents in acute myocardial infarction) trial. , 2011, Journal of the American College of Cardiology.

[38]  S. Ebrahim,et al.  Exercise-based cardiac rehabilitation for coronary heart disease. , 2011, The Cochrane database of systematic reviews.

[39]  M. Taskinen,et al.  ESC/EAS Guidelines for the management of dyslipidaemias: the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). , 2011, Atherosclerosis.

[40]  B. Gersh,et al.  Heparin plus a glycoprotein IIb/IIIa inhibitor versus bivalirudin monotherapy and paclitaxel-eluting stents versus bare-metal stents in acute myocardial infarction (HORIZONS-AMI): final 3-year results from a multicentre, randomised controlled trial , 2011, The Lancet.

[41]  C. Cannon,et al.  Ticagrelor versus clopidogrel in patients with acute coronary syndromes intended for non-invasive management: substudy from prospective randomised PLATelet inhibition and patient Outcomes (PLATO) trial , 2011, BMJ : British Medical Journal.

[42]  P. Janský,et al.  Pre-hospital treatment of STEMI patients. A scientific statement of the Working Group Acute Cardiac Care of the European Society of Cardiology , 2011, Acute cardiac care.

[43]  Yoshifumi Naka,et al.  Results of the post-U.S. Food and Drug Administration-approval study with a continuous flow left ventricular assist device as a bridge to heart transplantation: a prospective study using the INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support). , 2011, Journal of the American College of Cardiology.

[44]  C. Held,et al.  Association between adoption of evidence-based treatment and survival for patients with ST-elevation myocardial infarction. , 2011, JAMA.

[45]  G. Stone,et al.  Frequency and Predictors of Stent Thrombosis After Percutaneous Coronary Intervention in Acute Myocardial Infarction , 2011, Circulation.

[46]  X. Jouven,et al.  Mortality Associated With Atrial Fibrillation in Patients With Myocardial Infarction: A Systematic Review and Meta-Analysis , 2011, Circulation.

[47]  Masafumi Ueno,et al.  Pharmacodynamic Effects of Different Aspirin Dosing Regimens in Type 2 Diabetes Mellitus Patients With Coronary Artery Disease , 2011, Circulation. Cardiovascular interventions.

[48]  M. Mamas,et al.  Routine early coronary angioplasty versus ischaemia-guided angioplasty after thrombolysis in acute ST-elevation myocardial infarction: a meta-analysis. , 2011, European heart journal.

[49]  M. Zembala,et al.  Reperfusion by primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction within 12 to 24 hours of the onset of symptoms (from a prospective national observational study [PL-ACS]). , 2011, The American journal of cardiology.

[50]  B. Vessby,et al.  Randomized controlled trial of cognitive behavioral therapy vs standard treatment to prevent recurrent cardiovascular events in patients with coronary heart disease: Secondary Prevention in Uppsala Primary Health Care project (SUPRIM). , 2011, Archives of internal medicine.

[51]  Darren K Mcguire,et al.  Glucose-lowering targets for patients with cardiovascular disease: focus on inpatient management of patients with acute coronary syndromes. , 2010, Circulation.

[52]  J. Dillinger,et al.  24-hour time-dependent aspirin efficacy in patients with stable coronary artery disease , 2010, Thrombosis and Haemostasis.

[53]  J. Emparanza,et al.  Oxygen therapy for acute myocardial infarction. , 2010, The Cochrane database of systematic reviews.

[54]  Ole Fröbert,et al.  Thrombus Aspiration in ST-Elevation myocardial infarction in Scandinavia (TASTE trial). A multicenter, prospective, randomized, controlled clinical registry trial based on the Swedish angiography and angioplasty registry (SCAAR) platform. Study design and rationale. , 2010, American heart journal.

[55]  D. Holmes,et al.  How to treat patients with ST-elevation acute myocardial infarction and multi-vessel disease? , 2010, European heart journal.

[56]  C. Cannon,et al.  What Is the Optimal Blood Pressure in Patients After Acute Coronary Syndromes?: Relationship of Blood Pressure and Cardiovascular Events in the Pravastatin or Atorvastatin Evaluation and Infection Therapy–Thrombolysis in Myocardial Infarction (PROVE IT-TIMI) 22 Trial , 2010, Circulation.

[57]  G. Steinbeck,et al.  OMEGA, a Randomized, Placebo-Controlled Trial to Test the Effect of Highly Purified Omega-3 Fatty Acids on Top of Modern Guideline-Adjusted Therapy After Myocardial Infarction , 2010, Circulation.

[58]  C. Cannon,et al.  Ticagrelor Versus Clopidogrel in Patients With ST-Elevation Acute Coronary Syndromes Intended for Reperfusion With Primary Percutaneous Coronary Intervention: A Platelet Inhibition and Patient Outcomes (PLATO) Trial Subgroup Analysis , 2010, Circulation.

[59]  Deepak L. Bhatt,et al.  Clopidogrel with or without omeprazole in coronary artery disease. , 2010, The New England journal of medicine.

[60]  Roger D. White,et al.  Part 6: electrical therapies: automated external defibrillators, defibrillation, cardioversion, and pacing: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. , 2010, Circulation.

[61]  J. Marchesini,et al.  Randomized comparison of 6- versus 24-month clopidogrel therapy after balancing anti-intimal hyperplasia stent potency in all-comer patients undergoing percutaneous coronary intervention Design and rationale for the PROlonging Dual-antiplatelet treatment after Grading stent-induced Intimal hyperplas , 2010, American heart journal.

[62]  H. Arnesen,et al.  Frequency of left ventricular thrombus in patients with anterior wall acute myocardial infarction treated with percutaneous coronary intervention and dual antiplatelet therapy. , 2010, The American journal of cardiology.

[63]  F. Van de Werf,et al.  Underestimated and under-recognized: the late consequences of acute coronary syndrome (GRACE UK-Belgian Study). , 2010, European heart journal.

[64]  John E Billi,et al.  Part 1: Executive summary: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. , 2010, Circulation.

[65]  L. Rydén,et al.  Effect of postconditioning on infarct size in patients with ST elevation myocardial infarction , 2010, Heart.

[66]  P. Best,et al.  Acute myocardial infarction due to left circumflex artery occlusion and significance of ST-segment elevation. , 2010, The American journal of cardiology.

[67]  S. Yusuf,et al.  Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial , 2010, The Lancet.

[68]  Jeroen J. Bax,et al.  Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC). , 2010, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.

[69]  J. Soar,et al.  European Resuscitation Council Guidelines for Resuscitation 2010 Section 1. Executive summary. , 2010, Resuscitation.

[70]  J. Hartikainen,et al.  Long-Term Recording of Cardiac Arrhythmias With an Implantable Cardiac Monitor in Patients With Reduced Ejection Fraction After Acute Myocardial Infarction: The Cardiac Arrhythmias and Risk Stratification After Acute Myocardial Infarction (CARISMA) Study , 2010, Circulation.

[71]  Sunil V. Rao,et al.  Low-dose vs standard-dose unfractionated heparin for percutaneous coronary intervention in acute coronary syndromes treated with fondaparinux: the FUTURA/OASIS-8 randomized trial. , 2010, JAMA.

[72]  M. Keltai,et al.  Coronary Heart Disease Ticagrelor Versus Clopidogrel in Acute Coronary Syndromes in Relation to Renal Function Results From the Platelet Inhibition and Patient Outcomes (PLATO) Trial , 2010 .

[73]  Fredrik Folke,et al.  Risk of bleeding with single, dual, or triple therapy with warfarin, aspirin, and clopidogrel in patients with atrial fibrillation. , 2010, Archives of internal medicine.

[74]  P. Armstrong,et al.  Early routine percutaneous coronary intervention after fibrinolysis vs. standard therapy in ST-segment elevation myocardial infarction: a meta-analysis. , 2010, European heart journal.

[75]  Cheuk-Kwan Sun,et al.  Early extracorporeal membrane oxygenator-assisted primary percutaneous coronary intervention improved 30-day clinical outcomes in patients with ST-segment elevation myocardial infarction complicated with profound cardiogenic shock , 2010, Critical care medicine.

[76]  S. Stevens,et al.  Ticagrelor vs. clopidogrel in patients with acute coronary syndromes and diabetes: a substudy from the PLATelet inhibition and patient Outcomes (PLATO) trial , 2010, European heart journal.

[77]  C. Terkelsen,et al.  System delay and mortality among patients with STEMI treated with primary percutaneous coronary intervention. , 2010, JAMA.

[78]  C. Bode,et al.  Randomized comparison of eptifibatide versus abciximab in primary percutaneous coronary intervention in patients with acute ST-segment elevation myocardial infarction: results of the EVA-AMI Trial. , 2010, Journal of the American College of Cardiology.

[79]  B. Svennblad,et al.  Eptifibatide is noninferior to abciximab in primary percutaneous coronary intervention: results from the SCAAR (Swedish Coronary Angiography and Angioplasty Registry). , 2010, Journal of the American College of Cardiology.

[80]  Armando Pérez de Prado,et al.  Role of the Paclitaxel-Eluting Stent and Tirofiban in Patients With ST-Elevation Myocardial Infarction Undergoing Postfibrinolysis Angioplasty: The GRACIA-3 Randomized Clinical Trial , 2010, Circulation. Cardiovascular interventions.

[81]  P. Armstrong,et al.  The Strategic Reperfusion Early After Myocardial Infarction (STREAM) study. , 2010, American heart journal.

[82]  L. Wallentin,et al.  Relation between renal function, presentation, use of therapies and in‐hospital complications in acute coronary syndrome: data from the SWEDEHEART register , 2010, Journal of internal medicine.

[83]  P. Armstrong,et al.  Non-culprit coronary artery percutaneous coronary intervention during acute ST-segment elevation myocardial infarction: insights from the APEX-AMI trial. , 2010, European heart journal.

[84]  P. Kirchhof,et al.  Antithrombotic management of atrial fibrillation patients presenting with acute coronary syndrome and/or undergoing coronary stenting: executive summary--a Consensus Document of the European Society of Cardiology Working Group on Thrombosis, endorsed by the European Heart Rhythm Association (EHRA) a , 2010, European heart journal.

[85]  P. Stella,et al.  Effect of early, pre-hospital initiation of high bolus dose tirofiban in patients with ST-segment elevation myocardial infarction on short- and long-term clinical outcome. , 2010, Journal of the American College of Cardiology.

[86]  M. Jeong,et al.  Duration of dual antiplatelet therapy after implantation of drug-eluting stents. , 2010, The New England journal of medicine.

[87]  J. Vincent,et al.  Comparison of dopamine and norepinephrine in the treatment of shock. , 2010, The New England journal of medicine.

[88]  J. Ruskin,et al.  Amiodarone or procainamide for the termination of sustained stable ventricular tachycardia: an historical multicenter comparison. , 2010, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[89]  J. Tijssen,et al.  Right ventricular dysfunction is an independent predictor for mortality in ST‐elevation myocardial infarction patients presenting with cardiogenic shock on admission , 2010, European journal of heart failure.

[90]  S. de Servi,et al.  Urgent surgery in patients with a recently implanted coronary drug-eluting stent: a phase II study of 'bridging' antiplatelet therapy with tirofiban during temporary withdrawal of clopidogrel. , 2010, British journal of anaesthesia.

[91]  C. Terkelsen,et al.  Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial , 2010, The Lancet.

[92]  G. Lip.  Anticoagulation therapy and the risk of stroke in patients with atrial fibrillation at ‘moderate risk’ [CHADS2 score=1]: Simplifying stroke risk assessment and thromboprophylaxis in real-life clinical practice , 2010, Thrombosis and Haemostasis.

[93]  J. Jensen,et al.  Cardioprotective Effects of Ischemic Postconditioning in Patients Treated With Primary Percutaneous Coronary Intervention, Evaluated by Magnetic Resonance , 2010, Circulation. Cardiovascular interventions.

[94]  E. Topol,et al.  Enoxaparin in primary and facilitated percutaneous coronary intervention A formal prospective nonrandomized substudy of the FINESSE trial (Facilitated INtervention with Enhanced Reperfusion Speed to Stop Events). , 2010, JACC. Cardiovascular interventions.

[95]  K. Jolly,et al.  Home based versus centre based cardiac rehabilitation: Cochrane systematic review and meta-analysis , 2010, BMJ : British Medical Journal.

[96]  S. Halvorsen,et al.  Efficacy and safety of immediate angioplasty versus ischemia-guided management after thrombolysis in acute myocardial infarction in areas with very long transfer distances results of the NORDISTEMI (NORwegian study on DIstrict treatment of ST-elevation myocardial infarction). , 2010, Journal of the American College of Cardiology.

[97]  K. Werdan,et al.  Intra-aortic balloon counterpulsation in patients with acute myocardial infarction complicated by cardiogenic shock: The prospective, randomized IABP SHOCK Trial for attenuation of multiorgan dysfunction syndrome* , 2010, Critical care medicine.

[98]  Samin K. Sharma,et al.  Culprit vessel percutaneous coronary intervention versus multivessel and staged percutaneous coronary intervention for ST-segment elevation myocardial infarction patients with multivessel disease. , 2010, JACC. Cardiovascular interventions.

[99]  L. Morrison,et al.  Routine early angioplasty after fibrinolysis for acute myocardial infarction. , 2009, The New England journal of medicine.

[100]  A. Castro‐Beiras,et al.  Safety and feasibility of returning patients early to their originating centers after transfer for primary percutaneous coronary intervention. , 2009, Revista espanola de cardiologia.

[101]  J. Hartikainen,et al.  Reperfusion therapy for ST elevation acute myocardial infarction in Europe: description of the current situation in 30 countries , 2009, European heart journal.

[102]  R. Califf,et al.  Antiarrhythmic drug therapy for sustained ventricular arrhythmias complicating acute myocardial infarction* , 2009, Critical care medicine.

[103]  A. Lincoff,et al.  Magnitude and consequences of missing the acute infarct-related circumflex artery. , 2009, American heart journal.

[104]  G. De Luca,et al.  Risk profile and benefits from Gp IIb-IIIa inhibitors among patients with ST-segment elevation myocardial infarction treated with primary angioplasty: a meta-regression analysis of randomized trials , 2009, European heart journal.

[105]  B. Gersh,et al.  Bivalirudin in patients undergoing primary angioplasty for acute myocardial infarction (HORIZONS-AMI): 1-year results of a randomised controlled trial , 2009, The Lancet.

[106]  E. Topol,et al.  Benefit of facilitated percutaneous coronary intervention in high-risk ST-segment elevation myocardial infarction patients presenting to nonpercutaneous coronary intervention hospitals. , 2009, JACC. Cardiovascular interventions.

[107]  E. Antman,et al.  Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trials , 2009, The Lancet.

[108]  A. Kaltoft,et al.  Clinical impact of thrombectomy in acute ST-elevation myocardial infarction: an individual patient-data pooled analysis of 11 trials. , 2009, European heart journal.

[109]  P. Serruys,et al.  Percutaneous left ventricular assist devices vs. intra-aortic balloon pump counterpulsation for treatment of cardiogenic shock: a meta-analysis of controlled trials. , 2009, European heart journal.

[110]  Sunil V. Rao,et al.  Prevalence, predictors, and in-hospital outcomes of non-infarct artery intervention during primary percutaneous coronary intervention for ST-segment elevation myocardial infarction (from the National Cardiovascular Data Registry). , 2009, The American journal of cardiology.

[111]  M. Shishehbor,et al.  The association between early ventricular arrhythmias, renin-angiotensin-aldosterone system antagonism, and mortality in patients with ST-segment-elevation myocardial infarction: Insights from Global Use of Strategies to Open coronary arteries (GUSTO) V. , 2009, American heart journal.

[112]  K. Thygesen,et al.  How to set up an effective national primary angioplasty network: lessons learned from five European countries. , 2009, EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology.

[113]  P. Touboul,et al.  Comparison of primary angioplasty and pre-hospital fibrinolysis in acute myocardial infarction (CAPTIM) trial: a 5-year follow-up. , 2009, European heart journal.

[114]  K. Kern,et al.  Emergent percutaneous coronary intervention for resuscitated victims of out‐of‐hospital cardiac arrest , 2009, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.

[115]  A. Roguin,et al.  Incidence of early left ventricular thrombus after acute anterior wall myocardial infarction in the primary coronary intervention era. , 2009, American heart journal.

[116]  Y. Adler,et al.  Frequency and prognostic significance of pericarditis following acute myocardial infarction treated by primary percutaneous coronary intervention. , 2009, The American journal of cardiology.

[117]  Harlan M Krumholz,et al.  Association of door-to-balloon time and mortality in patients admitted to hospital with ST elevation myocardial infarction: national cohort study , 2009, BMJ : British Medical Journal.

[118]  P. Armstrong,et al.  Incidence of and outcomes associated with ventricular tachycardia or fibrillation in patients undergoing primary percutaneous coronary intervention. , 2009, JAMA.

[119]  S. Hohnloser,et al.  Atrial fibrillation in acute myocardial infarction: a systematic review of the incidence, clinical features and prognostic implications. , 2009, European heart journal.

[120]  S. Nekolla,et al.  Abciximab in Patients With Acute ST-Segment–Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention After Clopidogrel Loading: A Randomized Double-Blind Trial , 2009, Circulation.

[121]  B. McNally,et al.  Integration of pre-hospital electrocardiograms and ST-elevation myocardial infarction receiving center (SRC) networks: impact on Door-to-Balloon times across 10 independent regions. , 2009, JACC. Cardiovascular interventions.

[122]  Stephane Heritier,et al.  Intensive versus conventional glucose control in critically ill patients. , 2009, The New England journal of medicine.

[123]  Insung Chung,et al.  Faculty Opinions recommendation of Greater clinical benefit of more intensive oral antiplatelet therapy with prasugrel in patients with diabetes mellitus in the trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with prasugrel-Thrombolysis in Myocardial Infarction , 2009 .

[124]  J. Gore,et al.  Thirty-Year Trends (1975 to 2005) in the Magnitude of, Management of, and Hospital Death Rates Associated With Cardiogenic Shock in Patients With Acute Myocardial Infarction: A Population-Based Perspective , 2009, Circulation.

[125]  J. Fajadet,et al.  "Stent 4 Life" targeting PCI at all who will benefit the most. A joint project between EAPCI, Euro-PCR, EUCOMED and the ESC Working Group on Acute Cardiac Care. , 2009, EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology.

[126]  E. Antman,et al.  Prasugrel compared with clopidogrel in patients undergoing percutaneous coronary intervention for ST-elevation myocardial infarction (TRITON-TIMI 38): double-blind, randomised controlled trial , 2009, The Lancet.

[127]  A. Kastrati,et al.  Mechanical reperfusion and long-term mortality in patients with acute myocardial infarction presenting 12 to 48 hours from onset of symptoms. , 2009, JAMA.

[128]  D. Chamberlain,et al.  Thrombolysis during resuscitation for out-of-hospital cardiac arrest. , 2008, The New England journal of medicine.

[129]  D. Goldstein,et al.  Takotsubo Cardiomyopathy: A New Form of Acute, Reversible Heart Failure , 2008, Circulation.

[130]  Deepak L. Bhatt,et al.  Role of adjunctive thrombectomy and embolic protection devices in acute myocardial infarction: a comprehensive meta-analysis of randomized trials. , 2008, European heart journal.

[131]  Michael Weis,et al.  Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation: the Task Force on the Management of ST-Segment Elevation Acute Myocardial Infarction of the European Society of Cardiology. , 2008, European heart journal.

[132]  S. Solomon,et al.  Relation of mortality to failure to prescribe beta blockers acutely in patients with sustained ventricular tachycardia and ventricular fibrillation following acute myocardial infarction (from the VALsartan In Acute myocardial iNfarcTion trial [VALIANT] Registry). , 2008, The American journal of cardiology.

[133]  G. Lamas,et al.  Lack of benefit from percutaneous intervention of persistently occluded infarct arteries after the acute phase of myocardial infarction is time independent: insights from Occluded Artery Trial. , 2008, European heart journal.

[134]  L. Tavazzi,et al.  Global secondary prevention strategies to limit event recurrence after myocardial infarction: results of the GOSPEL study, a multicenter, randomized controlled trial from the Italian Cardiac Rehabilitation Network. , 2008, Archives of internal medicine.

[135]  Marc P. Bonaca,et al.  American College of Cardiology/American Heart Association/European Society of Cardiology/World Heart Federation universal definition of myocardial infarction classification system and the risk of cardiovascular death: observations from the TRITON-TIMI 38 trial (Trial to Assess Improvement in Therape , 2012, Circulation.

[136]  M. Vogelzang,et al.  Incidence and clinical consequences of distal embolization on the coronary angiogram after percutaneous coronary intervention for ST-elevation myocardial infarction. , 2008, European heart journal.

[137]  Pierre Croisille,et al.  Effect of cyclosporine on reperfusion injury in acute myocardial infarction. , 2008, The New England journal of medicine.

[138]  J. Ferrières,et al.  Comparison of Thrombolysis Followed by Broad Use of Percutaneous Coronary Intervention With Primary Percutaneous Coronary Intervention for ST-Segment–Elevation Acute Myocardial Infarction Data From the French Registry on Acute ST-Elevation Myocardial Infarction (FAST-MI) , 2008 .

[139]  F. Zijlstra,et al.  Cardiac death and reinfarction after 1 year in the Thrombus Aspiration during Percutaneous coronary intervention in Acute myocardial infarction Study (TAPAS): a 1-year follow-up study , 2008, The Lancet.

[140]  B. Gersh,et al.  Bivalirudin during primary PCI in acute myocardial infarction. , 2008, The New England journal of medicine.

[141]  A. Gavazzi,et al.  Aspirin desensitization in patients undergoing percutaneous coronary interventions with stent implantation. , 2008, The American journal of cardiology.

[142]  C. Terkelsen,et al.  Randomized comparison of distal protection versus conventional treatment in primary percutaneous coronary intervention: the drug elution and distal protection in ST-elevation myocardial infarction (DEDICATION) trial. , 2008, Journal of the American College of Cardiology.

[143]  G. Finet,et al.  Long-Term Benefit of Postconditioning , 2008, Circulation.

[144]  M. Flather,et al.  Immediate angioplasty versus standard therapy with rescue angioplasty after thrombolysis in the Combined Abciximab REteplase Stent Study in Acute Myocardial Infarction (CARESS-in-AMI): an open, prospective, randomised, multicentre trial , 2008, The Lancet.

[145]  D. Jacobs,et al.  Relation of length of hospital stay in acute myocardial infarction to postdischarge mortality. , 2008, The American journal of cardiology.

[146]  S. Yusuf,et al.  Effects of fondaparinux in patients with ST-segment elevation acute myocardial infarction not receiving reperfusion treatment. , 2008, European heart journal.

[147]  Salim Yusuf,et al.  The role of fondaparinux as an adjunct to thrombolytic therapy in acute myocardial infarction: a subgroup analysis of the OASIS-6 trial. , 2008, European heart journal.

[148]  Dominique Mottier,et al.  Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study. , 2008, Journal of the American College of Cardiology.

[149]  J. Trickett,et al.  A citywide protocol for primary PCI in ST-segment elevation myocardial infarction. , 2008, The New England journal of medicine.

[150]  G. Lip,et al.  Antithrombotic therapy in patients treated with oral anticoagulation undergoing coronary artery stenting. An expert consensus document with focus on atrial fibrillation , 2008, Annals of medicine.

[151]  J. Ioannidis,et al.  Percutaneous coronary intervention for late reperfusion after myocardial infarction in stable patients. , 2007, American heart journal.

[152]  M. Pfisterer,et al.  Hemodynamic parameters are prognostically important in cardiogenic shock but similar following early revascularization or initial medical stabilization: a report from the SHOCK Trial. , 2007, Chest.

[153]  S. Yusuf,et al.  Glucose-insulin-potassium therapy in patients with ST-segment elevation myocardial infarction. , 2007, JAMA.

[154]  E. Antman,et al.  Prasugrel versus clopidogrel in patients with acute coronary syndromes. , 2007, The New England journal of medicine.

[155]  André Lamy,et al.  F-18-fluorodeoxyglucose positron emission tomography imaging-assisted management of patients with severe left ventricular dysfunction and suspected coronary disease: a randomized, controlled trial (PARR-2). , 2007, Journal of the American College of Cardiology.

[156]  P. Aegerter,et al.  Efficacy of therapeutic hypothermia after out-of-hospital cardiac arrest due to ventricular fibrillation. , 2007, Resuscitation.

[157]  J. Daubert,et al.  Guidelines for cardiac pacing and cardiac resynchronization therapy: The Task Force for Cardiac Pacing and Cardiac Resynchronization Therapy of the European Society of Cardiology. Developed in collaboration with the European Heart Rhythm Association. , 2007, European heart journal.

[158]  Timothy D. Henry,et al.  A Regional System to Provide Timely Access to Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction , 2007, Circulation.

[159]  Harel Gilutz,et al.  Benefit of direct ambulance to coronary care unit admission of acute myocardial infarction patients undergoing primary percutaneous intervention. , 2007, International journal of cardiology.

[160]  P. Janský,et al.  The incidence, treatment strategies and outcomes of acute coronary syndromes in the "reperfusion network" of different hospital types in the Czech Republic: results of the Czech evaluation of acute coronary syndromes in hospitalized patients (CZECH) registry. , 2007, International journal of cardiology.

[161]  H. Krumholz,et al.  Development of Systems of Care for ST-Elevation Myocardial Infarction Patients: Gaps, Barriers, and Implications , 2007, Circulation.

[162]  A. Budaj,et al.  Relationship of ST elevation in lead aVR with angiographic findings and outcome in non-ST elevation acute coronary syndromes. , 2007, American heart journal.

[163]  A. Parkhomenko,et al.  Enoxaparin is superior to unfractionated heparin in patients with ST elevation myocardial infarction undergoing fibrinolysis regardless of the choice of lytic: an ExTRACT-TIMI 25 analysis. , 2007, European heart journal.

[164]  K. Eagle,et al.  Decline in rates of death and heart failure in acute coronary syndromes, 1999-2006. , 2007, JAMA.

[165]  E. Antman,et al.  Enoxaparin vs. unfractionated heparin with fibrinolysis for ST-elevation myocardial infarction in elderly and younger patients: results from ExTRACT-TIMI 25. , 2007, European heart journal.

[166]  Timothy J Gardner,et al.  Prevention of premature discontinuation of dual antiplatelet therapy in patients with coronary artery stents: a science advisory from the American Heart Association, American College of Cardiology, Society for Cardiovascular Angiography and Interventions, American College of Surgeons, and American D , 2007, Circulation.

[167]  F. Van de Werf,et al.  Effect of tilarginine acetate in patients with acute myocardial infarction and cardiogenic shock: the TRIUMPH randomized controlled trial. , 2007, JAMA.

[168]  F. Fernández‐Avilés,et al.  Primary angioplasty vs. early routine post-fibrinolysis angioplasty for acute myocardial infarction with ST-segment elevation: the GRACIA-2 non-inferiority, randomized, controlled trial. , 2007, European heart journal.

[169]  P. Lesault,et al.  Six-Month Outcome of Emergency Percutaneous Coronary Intervention in Resuscitated Patients After Cardiac Arrest Complicating ST-Elevation Myocardial Infarction , 2007, Circulation.

[170]  I. Durand-zaleski,et al.  Gender Differences in Hospital Mortality and Use of Percutaneous Coronary Intervention in Acute Myocardial Infarction: Microsimulation Analysis of the 1999 Nationwide French Hospitals Database , 2007, Circulation.

[171]  M. Guglin,et al.  Ultrafiltration versus intravenous diuretics for patients hospitalized for acute decompensated heart failure. , 2007, Journal of the American College of Cardiology.

[172]  Nathaniel A. Page,et al.  Rapid Desensitization Protocols for Patients with Cardiovascular Disease and Aspirin Hypersensitivity in an Era of Dual Antiplatelet Therapy , 2007, The Annals of pharmacotherapy.

[173]  G. Lamas,et al.  Coronary intervention for persistent occlusion after myocardial infarction. , 2006, The New England journal of medicine.

[174]  C. Tracy,et al.  [Guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Executive summary]. , 2006, Revista espanola de cardiologia.

[175]  Harlan M Krumholz,et al.  Strategies for reducing the door-to-balloon time in acute myocardial infarction. , 2006, The New England journal of medicine.

[176]  David P Miller,et al.  Hospital Delays in Reperfusion for ST-Elevation Myocardial Infarction: Implications When Selecting a Reperfusion Strategy , 2006, Circulation.

[177]  K. Eagle,et al.  Prediction of risk of death and myocardial infarction in the six months after presentation with acute coronary syndrome: prospective multinational observational study (GRACE) , 2006, BMJ : British Medical Journal.

[178]  G. Filippatos,et al.  The second Euro Heart Survey on acute coronary syndromes: Characteristics, treatment, and outcome of patients with ACS in Europe and the Mediterranean Basin in 2004. , 2006, European heart journal.

[179]  C. Tseng,et al.  Interhospital transfer for early revascularization in patients with ST-elevation myocardial infarction complicated by cardiogenic shock--a report from the SHould we revascularize Occluded Coronaries for cardiogenic shocK? (SHOCK) trial and registry. , 2006, American heart journal.

[180]  P. Steg,et al.  Bypassing the emergency room reduces delays and mortality in ST elevation myocardial infarction: the USIC 2000 registry , 2006, Heart.

[181]  Peter Lindgren,et al.  Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary , 2007 .

[182]  G. Maurer,et al.  Implementation of Guidelines Improves the Standard of Care: The Viennese Registry on Reperfusion Strategies in ST-Elevation Myocardial Infarction (Vienna STEMI Registry) , 2006, Circulation.

[183]  S. Yusuf,et al.  Effects of fondaparinux on mortality and reinfarction in patients with acute ST-segment elevation myocardial infarction: the OASIS-6 randomized trial. , 2006, JAMA.

[184]  E. Boersma,et al.  Does time matter? A pooled analysis of randomized clinical trials comparing primary percutaneous coronary intervention and in-hospital fibrinolysis in acute myocardial infarction patients. , 2006, European heart journal.

[185]  L. Newby,et al.  Frequency and consequences of recording an electrocardiogram >10 minutes after arrival in an emergency room in non-ST-segment elevation acute coronary syndromes (from the CRUSADE Initiative). , 2006, The American journal of cardiology.

[186]  P. Armstrong,et al.  Primary versus tenecteplase-facilitated percutaneous coronary intervention in patients with ST-segment elevation acute myocardial infarction (ASSENT-4 PCI): randomised trial , 2006, The Lancet.

[187]  F. Van de Werf,et al.  Intervention in acute coronary syndromes: do patients undergo intervention on the basis of their risk characteristics? The Global Registry of Acute Coronary Events (GRACE) , 2005, Heart.

[188]  S. Stevens,et al.  Rescue angioplasty after failed thrombolytic therapy for acute myocardial infarction. , 2005, The New England journal of medicine.

[189]  K. Alexander,et al.  Excess dosing of antiplatelet and antithrombin agents in the treatment of non-ST-segment elevation acute coronary syndromes. , 2005, JAMA.

[190]  R. Collins,et al.  Early intravenous then oral metoprolol in 45 852 patients with acute myocardial infarction: randomised placebo-controlled trial , 2005, The Lancet.

[191]  R. Collins,et al.  Addition of clopidogrel to aspirin in 45 852 patients with acute myocardial infarction: randomised placebo-controlled trial , 2005, The Lancet.

[192]  R. Collins,et al.  Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90 056 participants in 14 randomised trials of statins , 2005, The Lancet.

[193]  Vic Hasselblad,et al.  Impact of the pulmonary artery catheter in critically ill patients: meta-analysis of randomized clinical trials. , 2005, JAMA.

[194]  G. Finet,et al.  Postconditioning the Human Heart , 2005, Circulation.

[195]  R. de Caterina,et al.  Pre-hospital reperfusion therapy: a strategy to improve therapeutic outcome in patients with ST-elevation myocardial infarction. , 2005, European heart journal.

[196]  S. Nekolla,et al.  Mechanical reperfusion in patients with acute myocardial infarction presenting more than 12 hours from symptom onset: a randomized controlled trial. , 2005, JAMA.

[197]  G. Wells,et al.  Combined angioplasty and pharmacological intervention versus thrombolysis alone in acute myocardial infarction (CAPITAL AMI study). , 2005, Journal of the American College of Cardiology.

[198]  A. Parkhomenko,et al.  Recommendations for the structure, organization, and operation of intensive cardiac care units. , 2005, European heart journal.

[199]  A. Battler,et al.  Left ventricular mural thrombus after anterior ST-segment-elevation acute myocardial infarction in the era of aggressive reperfusion therapy – still a frequent complication , 2005, Coronary artery disease.

[200]  M. Sabatine,et al.  Addition of Clopidogrel to Aspirin and Fibrinolytic Therapy for Myocardial Infarction With ST-Segment Elevation , 2005 .

[201]  J. Jollis,et al.  Safety and effectiveness of transdermal nicotine patch in smokers admitted with acute coronary syndromes. , 2005, The American journal of cardiology.

[202]  E. Antman,et al.  Abciximab as adjunctive therapy to reperfusion in acute ST-segment elevation myocardial infarction: a meta-analysis of randomized trials. , 2005, JAMA.

[203]  B. Gersh,et al.  Combined prognostic utility of ST-segment recovery and myocardial blush after primary percutaneous coronary intervention in acute myocardial infarction. , 2005, European heart journal.

[204]  A. Skene,et al.  Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevation. , 2005, The New England journal of medicine.

[205]  P. Armstrong,et al.  Time to treatment and the impact of a physician on prehospital management of acute ST elevation myocardial infarction: insights from the ASSENT-3 PLUS trial , 2005, Heart.

[206]  P. Steg,et al.  Rapid desensitization procedure for patients with aspirin hypersensitivity undergoing coronary stenting. , 2005, The American journal of cardiology.

[207]  L. Shaw,et al.  Thrombolysis and Counterpulsation to Improve Survival in Myocardial Infarction Complicated by Hypotension and Suspected Cardiogenic Shock or Heart Failure: Results of the TACTICS Trial , 2005, Journal of Thrombosis and Thrombolysis.

[208]  Douglas L Packer,et al.  Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. , 2005, The New England journal of medicine.

[209]  Ralph D'Agostino,et al.  Combination of isosorbide dinitrate and hydralazine in blacks with heart failure. , 2004, The New England journal of medicine.

[210]  L. Rydén,et al.  Newly detected abnormal glucose tolerance: an important predictor of long-term outcome after myocardial infarction. , 2004, European heart journal.

[211]  Roberto Ferrari,et al.  The prevalence of abnormal glucose regulation in patients with coronary artery disease across Europe. The Euro Heart Survey on diabetes and the heart. , 2004, European heart journal.

[212]  F. Fernández‐Avilés,et al.  Routine invasive strategy within 24 hours of thrombolysis versus ischaemia-guided conservative approach for acute myocardial infarction with ST-segment elevation (GRACIA-1): a randomised controlled trial , 2004, The Lancet.

[213]  P. Poole‐Wilson,et al.  Effect of long-acting nifedipine on mortality and cardiovascular morbidity in patients with stable angina requiring treatment (ACTION trial): randomised controlled trial , 2004, The Lancet.

[214]  J. McMurray,et al.  Multidisciplinary strategies for the management of heart failure patients at high risk for admission: a systematic review of randomized trials. , 2004, Journal of the American College of Cardiology.

[215]  David Brieger,et al.  Acute coronary syndromes without chest pain, an underdiagnosed and undertreated high-risk group: insights from the Global Registry of Acute Coronary Events. , 2004, Chest.

[216]  H. Burri,et al.  Perioperative outcome and long-term survival of surgery for acute post-infarction mitral regurgitation. , 2004, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[217]  Felix Zijlstra,et al.  Prognostic Assessment of Patients With Acute Myocardial Infarction Treated With Primary Angioplasty: Implications for Early Discharge , 2004, Circulation.

[218]  S. Ebrahim,et al.  Exercise-based rehabilitation for patients with coronary heart disease: systematic review and meta-analysis of randomized controlled trials. , 2004, The American journal of medicine.

[219]  J. Gore,et al.  Declining length of hospital stay for acute myocardial infarction and postdischarge outcomes: a community-wide perspective. , 2004, Archives of internal medicine.

[220]  S. Reis,et al.  Women's Ischemic Syndrome Evaluation: current status and future research directions: report of the National Heart, Lung and Blood Institute workshop: October 2-4, 2002: Section 2: stable ischemia: pathophysiology and gender differences. , 2004, Circulation.

[221]  L. Shaw,et al.  Women's Ischemic Syndrome Evaluation: current status and future research directions: report of the National Heart, Lung and Blood Institute workshop: October 2-4, 2002: executive summary. , 2004, Circulation.

[222]  T. Harr,et al.  Clinical outcomes of primary stenting versus balloon angioplasty in patients with myocardial infarction: a meta-analysis of randomized controlled trials. , 2004, The American journal of medicine.

[223]  P. Touboul,et al.  Impact of Time to Treatment on Mortality After Prehospital Fibrinolysis or Primary Angioplasty: Data From the CAPTIM Randomized Clinical Trial , 2003, Circulation.

[224]  Karl Swedberg,et al.  Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both. , 2003, The New England journal of medicine.

[225]  H. White,et al.  The safety and efficacy of subcutaneous enoxaparin versus intravenous unfractionated heparin and tirofiban versus placebo in the treatment of acute ST-segment elevation myocardial infarction patients ineligible for reperfusion (TETAMI): a randomized trial. , 2003, Journal of the American College of Cardiology.

[226]  K. Fox,et al.  Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study) , 2003, The Lancet.

[227]  Klaus Rasmussen,et al.  A comparison of coronary angioplasty with fibrinolytic therapy in acute myocardial infarction. , 2003, The New England journal of medicine.

[228]  C. Hofer,et al.  Beneficial effects of immediate stenting after thrombolysis in acute myocardial infarction. , 2003, Journal of the American College of Cardiology.

[229]  P. Poole‐Wilson,et al.  Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial , 2003, The Lancet.

[230]  B. Pitt,et al.  Eplerenone , a Selective Aldosterone Blocker , in Patients with Left Ventricular Dysfunction after Myocardial Infarction , 2003 .

[231]  Douglas S Lee,et al.  Effectiveness of implantable defibrillators for preventing arrhythmic events and death: a meta-analysis. , 2003, Journal of the American College of Cardiology.

[232]  C. Thomson,et al.  Hospital- and clinic-based smoking cessation interventions for smokers with cardiovascular disease. , 2003, Progress in cardiovascular diseases.

[233]  J. Boura,et al.  Primary angioplasty vs. intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of 23 randomized trials , 2003 .

[234]  H. White,et al.  Echocardiographic Predictors of Survival and Response to Early Revascularization in Cardiogenic Shock , 2003, Circulation.

[235]  Eric J Topol,et al.  Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial. , 2002, JAMA.

[236]  N. Freemantle,et al.  The effectiveness and relative effectiveness of intravenous inotropic drugs acting through the adrenergic pathway in patients with heart failure—a meta‐regression analysis , 2002, European journal of heart failure.

[237]  Karen Smith,et al.  Treatment of Comatose Survivors of Out-of-hospital Cardiac Arrest With Induced Hypothermia , 2003 .

[238]  H. Heidbuchel,et al.  Enoxaparin as Adjunctive Antithrombin Therapy for ST-Elevation Myocardial Infarction: Results of the ENTIRE-Thrombolysis in Myocardial Infarction (TIMI) 23 Trial , 2002, Circulation.

[239]  L. Shaw,et al.  Myocardial viability testing and impact of revascularization on prognosis in patients with coronary artery disease and left ventricular dysfunction: a meta-analysis. , 2002, Journal of the American College of Cardiology.

[240]  Victor F. Froelicher,et al.  Exercise capacity and mortality among men referred for exercise testing. , 2002, The New England journal of medicine.

[241]  Alan D. Lopez,et al.  Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest , 2002 .

[242]  A. Kastrati,et al.  Sex-based analysis of outcome in patients with acute myocardial infarction treated predominantly with percutaneous coronary intervention. , 2002, JAMA.

[243]  H. White,et al.  Thrombin-specific anticoagulation with bivalirudin versus heparin in patients receiving fibrinolytic therapy for acute myocardial infarction: the HERO-2 randomised trial , 2001, The Lancet.

[244]  P. Armstrong,et al.  Incidence and predictors of bleeding events after fibrinolytic therapy with fibrin-specific agents: a comparison of TNK-tPA and rt-PA. , 2001, European heart journal.

[245]  Salim Yusuf,et al.  Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study , 2001, The Lancet.

[246]  A. Wierzbicki,et al.  Atorvastatin for acute coronary syndromes. , 2001, JAMA.

[247]  D. DeMets,et al.  Effect of carvedilol on survival in severe chronic heart failure. , 2001, The New England journal of medicine.

[248]  H. Dargie,et al.  Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial , 2001, The Lancet.

[249]  L. Sleeper,et al.  Trends in cardiogenic shock: report from the SHOCK Study. The SHould we emergently revascularize Occluded Coronaries for cardiogenic shocK? , 2001, European heart journal.

[250]  J. Brugada,et al.  Coronary artery revascularization in patients with sustained ventricular arrhythmias in the chronic phase of a myocardial infarction: effects on the electrophysiologic substrate and outcome. , 2001, Journal of the American College of Cardiology.

[251]  H. White,et al.  One-year survival following early revascularization for cardiogenic shock. , 2001, JAMA.

[252]  E. Antman,et al.  TIMI Risk Score for ST-Elevation Myocardial Infarction: A Convenient, Bedside, Clinical Score for Risk Assessment at Presentation: An Intravenous nPA for Treatment of Infarcting Myocardium Early II Trial Substudy , 2000, Circulation.

[253]  J. Ottervanger,et al.  Long-term benefit of primary angioplasty compared to thrombolytic therapy for acute myocardial infarction. , 2000, European heart journal.

[254]  O. Alfieri,et al.  Sensitivity, specificity, and predictive accuracies of non-invasive tests, singly and in combination, for diagnosis of hibernating myocardium. , 2000, European heart journal.

[255]  H A Feldman,et al.  Effect of a community intervention on patient delay and emergency medical service use in acute coronary heart disease: The Rapid Early Action for Coronary Treatment (REACT) Trial. , 2000, JAMA.

[256]  B. Pitt,et al.  The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure , 2000 .

[257]  F. Werf.  Single-bolus tenecteplase compared with front-loaded alteplase in acute myocardial infarction: the ASSENT-2 double-blind randomised trial , 1999, The Lancet.

[258]  H. White,et al.  Early revascularization in acute myocardial infarction complicated by cardiogenic shock. SHOCK Investigators. Should We Emergently Revascularize Occluded Coronaries for Cardiogenic Shock. , 1999, The New England journal of medicine.

[259]  Roberto Marchioli,et al.  Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico. , 1999 .

[260]  S. Pocock,et al.  A clinical trial comparing three antithrombotic-drug regimens after coronary-artery stenting. Stent Anticoagulation Restenosis Study Investigators. , 1999, The New England journal of medicine.

[261]  J. J. Griffin,et al.  Clinical and angiographic follow-Up after primary stenting in acute myocardial infarction: the Primary Angioplasty in Myocardial Infarction (PAMI) stent pilot trial. , 1999, Circulation.

[262]  A. Go,et al.  Should the electrocardiogram be used to guide therapy for patients with left bundle-branch block and suspected myocardial infarction? , 1999, JAMA.

[263]  CIBIS-II Investigators and Committees.  The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial , 1999, The Lancet.

[264]  J. Bache.  European Resuscitation Council Guidelines for Resuscitation , 1998 .

[265]  E. Topol.  A comparison of reteplase with alteplase for acute myocardial infarction. , 1998, The New England journal of medicine.

[266]  G. Stone,et al.  Safety and cost-effectiveness of early discharge after primary angioplasty in low risk patients with acute myocardial infarction. PAMI-II Investigators. Primary Angioplasty in Myocardial Infarction. , 1998, Journal of the American College of Cardiology.

[267]  D. Zahger.  Immediate coronary angiography in survivors of out-of-hospital cardiac arrest. , 1997, The New England journal of medicine.

[268]  H. Arendrup,et al.  Danish multicenter randomized study of invasive versus conservative treatment in patients with inducible ischemia after thrombolysis in acute myocardial infarction (DANAMI). DANish trial in Acute Myocardial Infarction. , 1997, Circulation.

[269]  M. Dennis.  A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee , 1996 .

[270]  Eric Boersma,et al.  Early thrombolytic treatment in acute myocardial infarction: reappraisal of the golden hour , 1996, The Lancet.

[271]  M. Hadamitzky,et al.  A randomized comparison of antiplatelet and anticoagulant therapy after the placement of coronary-artery stents. , 1996, The New England journal of medicine.

[272]  G S Wagner,et al.  Electrocardiographic diagnosis of evolving acute myocardial infarction in the presence of left bundle-branch block. GUSTO-1 (Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries) Investigators. , 1996, The New England journal of medicine.

[273]  E. Keeley,et al.  Left Ventricular Mural Thrombus after Acute Myocardial Infarction , 1996, Clinical cardiology.

[274]  E. Aliot,et al.  A clinical trial of the angiotensin-converting-enzyme inhibitor trandolapril in patients with left ventricular dysfunction after myocardial infarction. Trandolapril Cardiac Evaluation (TRACE) Study Group. , 1995, The New England journal of medicine.

[275]  M. Chang,et al.  Acute treatment of recent-onset atrial fibrillation and flutter with a tailored dosing regimen of intravenous amiodarone. A randomized, digoxin-controlled study. , 1995, European heart journal.

[276]  J Col,et al.  Predictors of 30-day mortality in the era of reperfusion for acute myocardial infarction. Results from an international trial of 41,021 patients. GUSTO-I Investigators. , 1995, Circulation.

[277]  M Akhtar,et al.  Ventricular Fibrillation and Polymorphic Ventricular Tachycardia with Critical Coronary Artery Stenosis: , 1994, Journal of cardiovascular electrophysiology.

[278]  E. Topol,et al.  Randomized comparison of rescue angioplasty with conservative management of patients with early failure of thrombolysis for acute anterior myocardial infarction. , 1994, Circulation.

[279]  P. Ringo.  An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction , 1994 .

[280]  Fibrinolytic Therapy Trialists' Collaborative Group.  Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients , 1994, The Lancet.

[281]  Gusto Angiographic Investigators.  The effects of tissue plasminogen activator, streptokinase, or both on coronary-artery patency, ventricular function, and survival after acute myocardial infarction. , 1993, The New England journal of medicine.

[282]  G. Murray,et al.  Effect of ramipril on mortality and morbidity of survivors of acute myocardial infarction with clinical evidence of heart failure. The Acute Infarction Ramipril Efficacy (AIRE) Study Investigators , 1993 .

[283]  O. Topaz,et al.  Interventricular septal rupture complicating acute myocardial infarction: from pathophysiologic features to the role of invasive and noninvasive diagnostic modalities in current management. , 1992, The American journal of medicine.

[284]  E. J. Brown,et al.  Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. The SAVE Investigators. , 1992, The New England journal of medicine.

[285]  B. Gersh,et al.  Prognosis in rupture of the ventricular septum after acute myocardial infarction and role of early surgical intervention. , 1992, The American journal of cardiology.

[286]  M. Pfisterer,et al.  Effect of early intravenous heparin on coronary patency, infarct size, and bleeding complications after alteplase thrombolysis: results of a randomised double blind European Cooperative Study Group trial. , 1992, British heart journal.

[287]  N. Dudley.  Thrombolytic therapy in the elderly. , 1991, Postgraduate medical journal.

[288]  C. Furberg,et al.  Update of effects of calcium antagonists in myocardial infarction or angina in light of the second Danish Verapamil Infarction Trial (DAVIT-II) and other recent studies. , 1991, The American journal of cardiology.

[289]  C. Taylor,et al.  Smoking cessation after acute myocardial infarction: effects of a nurse-managed intervention. , 1990, Annals of internal medicine.

[290]  H. Huikuri,et al.  Efficacy of intravenous propranolol for suppression of inducibility of ventricular tachyarrhythmias with different electrophysiologic characteristics in coronary artery disease. , 1989, The American journal of cardiology.

[291]  N. Laird,et al.  Meta-analytic evidence against prophylactic use of lidocaine in acute myocardial infarction. , 1989, Archives of internal medicine.

[292]  D. Doyle,et al.  Comparison of high-dose with low-dose subcutaneous heparin to prevent left ventricular mural thrombosis in patients with acute transmural anterior myocardial infarction. , 1989, The New England journal of medicine.

[293]  S. Chierchia,et al.  Intermittent coronary occlusion in acute myocardial infarction. Value of combined thrombolytic and vasodilator therapy. , 1987, The New England journal of medicine.

[294]  J. López-Sendón,et al.  Electrocardiographic findings in acute right ventricular infarction: sensitivity and specificity of electrocardiographic alterations in right precordial leads V4R, V3R, V1, V2, and V3. , 1985, Journal of the American College of Cardiology.

[295]  D. Chamberlain,et al.  Five hundred patients with myocardial infarction monitored within one hour of symptoms. , 1983, British medical journal.

[296]  J. Seward,et al.  Mural thrombus in left ventricular aneurysm: incidence, role of angiography, and relation between anticoagulation and embolization. , 1981, Mayo Clinic proceedings.

[297]  Benefit of Transferring ST-Segment–Elevation Myocardial Infarction Patients for Percutaneous Coronary Intervention Compared With Administration of Onsite Fibrinolytic Declines as Delays Increase , 2012 .

[298]  B. Gersh.  Radial versus femoral access for coronary angiography and intervention in patients with acute coronary syndromes (RIVAL): a randomised, parallel group, multicentre trial , 2012 .

[299]  M. Masotti,et al.  Ischaemic postconditioning revisited: lack of effects on infarct size following primary percutaneous coronary intervention. , 2012, European heart journal.

[300]  B. Gersh.  Clinical Events as a Function of Proton Pump Inhibitor Use, Clopidogrel Use, and Cytochrome P450 2C19 Genotype in a Large Nationwide Cohort of Acute Myocardial Infarction: Results From the French Registry of Acute ST-Elevation and Non–ST-Elevation Myocardial Infarction (FAST-MI) Registry , 2012 .

[301]  K. Devault,et al.  ACCF/ACG/AHA 2010 Expert Consensus Document on the Concomitant Use of Proton Pump Inhibitors and Thienopyridines: A Focused Update of the ACCF/ACG/AHA 2008 Expert Consensus Document on Reducing the Gastrointestinal Risks of Antiplatelet Therapy and NSAID Use , 2011 .

[302]  D. McManus,et al.  Recent trends in the incidence, treatment, and outcomes of patients with STEMI and NSTEMI. , 2011, The American journal of medicine.

[303]  Baris Gencer,et al.  ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation , 2011 .

[304]  M. Taskinen,et al.  ESC/EAS Guidelines for the management of dyslipidaemias The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). , 2011, Atherosclerosis.

[305]  E. Topol,et al.  Tirofiban as adjunctive therapy for acute coronary syndromes and percutaneous coronary intervention: a meta-analysis of randomized trials. , 2010, European heart journal.

[306]  S. Werns.  A systematic review and meta-analysis of intra-aortic balloon pump therapy in ST-elevation myocardial infarction: should we change the guidelines? , 2010 .

[307]  Rizwan Afzal,et al.  Safety and feasibility of early hospital discharge in ST-segment elevation myocardial infarction--a prospective and randomized trial in low-risk primary percutaneous coronary intervention patients (the Safe-Depart Trial). , 2010, American heart journal.

[308]  Biomed Programme.  Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials , 2009 .

[309]  Claes Held,et al.  Ticagrelor versus clopidogrel in patients with acute coronary syndromes. , 2009, The New England journal of medicine.

[310]  B. Gersh.  Facilitated PCI in Patients with ST-Elevation Myocardial Infarction , 2009 .

[311]  B. Uretsky,et al.  Thrombus aspiration during primary percutaneous coronary intervention. , 2008, The New England journal of medicine.

[312]  Thomas Weber,et al.  Intensive versus moderate lipid lowering with statins after acute coronary syndromes. , 2004, The New England journal of medicine.

[313]  V. Hasselblad,et al.  Time-based risk assessment after myocardial infarction. Implications for timing of discharge and applications to medical decision-making. , 2003, European heart journal.

[314]  L. Sleeper,et al.  Early revascularization is associated with improved survival in elderly patients with acute myocardial infarction complicated by cardiogenic shock: a report from the SHOCK Trial Registry. , 2003, European heart journal.

[315]  M. Aschermann,et al.  Long distance transport for primary angioplasty vs immediate thrombolysis in acute myocardial infarction. Final results of the randomized national multicentre trial--PRAGUE-2. , 2003, European heart journal.

[316]  E. Bonnefoy,et al.  Primary angioplasty vs. prehospital fibrinolysis in acute myocardial infarction: a randomised study☆ , 2003 .

[317]  K. Coyne,et al.  Randomized Comparison of Enoxaparin, a Low-Molecular-Weight Heparin, With Unfractionated Heparin Adjunctive to Recombinant Tissue Plasminogen Activator Thrombolysis and Aspirin Second Trial of Heparin and Aspirin Reperfusion Therapy (HART II) , 2002 .

[318]  P. R. R. Ecurrent,et al.  EFFECTS OF CLOPIDOGREL IN ADDITION TO ASPIRIN IN PATIENTS WITH ACUTE CORONARY SYNDROMES WITHOUT ST-SEGMENT ELEVATION , 2001 .

[319]  Marlene R. Miller,et al.  The evidence regarding the drugs used for ventricular rate control. , 2000, The Journal of family practice.

[320]  H. White,et al.  The clinical profile of patients with suspected cardiogenic shock due to predominant left ventricular failure: a report from the SHOCK Trial Registry. SHould we emergently revascularize Occluded Coronaries in cardiogenic shocK? , 2000, Journal of the American College of Cardiology.

[321]  K. Lee,et al.  Incidence and predictors of bleeding after contemporary thrombolytic therapy for myocardial infarction. The Global Utilization of Streptokinase and Tissue Plasminogen activator for Occluded coronary arteries (GUSTO) I Investigators. , 1997, Circulation.

[322]  J. F. Hansen,et al.  Effect of verapamil on mortality and major events after acute myocardial infarction (the Danish Verapamil Infarction Trial II--DAVIT II) , 1990, The American journal of cardiology.