Genomics of Alzheimer’s disease

[1]  Timothy J. Hohman,et al.  Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk , 2019, Nature Genetics.

[2]  M. Gearing,et al.  Integrated proteomics and network analysis identifies protein hubs and network alterations in Alzheimer’s disease , 2018, Acta neuropathologica communications.

[3]  Nick C Fox,et al.  Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease , 2017, Nature Genetics.

[4]  K. Lunetta,et al.  Transethnic genome-wide scan identifies novel Alzheimer's disease loci , 2017, Alzheimer's & Dementia.

[5]  A. Lusis,et al.  Multi-omics approaches to disease , 2017, Genome Biology.

[6]  Alzheimer’s Association 2017 Alzheimer's disease facts and figures , 2017, Alzheimer's & Dementia.

[7]  D. Galasko,et al.  Alzheimer disease: CSF biomarkers for Alzheimer disease — approaching consensus , 2017, Nature Reviews Neurology.

[8]  Yaniv Erlich,et al.  Case–control association mapping by proxy using family history of disease , 2017, Nature Genetics.

[9]  P. Battista,et al.  Frontiers for the Early Diagnosis of AD by Means of MRI Brain Imaging and Support Vector Machines. , 2016, Current Alzheimer research.

[10]  P. Sachdev,et al.  Circulating microRNAs as Biomarkers of Alzheimer's Disease: A Systematic Review. , 2015, Journal of Alzheimer's disease : JAD.

[11]  H. Stefánsson,et al.  Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease , 2015, Circulation.

[12]  Karl Herrup,et al.  The case for rejecting the amyloid cascade hypothesis , 2015, Nature Neuroscience.

[13]  Burkhard Becher,et al.  Immune attack: the role of inflammation in Alzheimer disease , 2015, Nature Reviews Neuroscience.

[14]  Manolis Kellis,et al.  Alzheimer’s loci: epigenetic associations and interaction with genetic factors , 2015, Annals of clinical and translational neurology.

[15]  H. Stefánsson,et al.  Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease , 2015, Nature Genetics.

[16]  P. Elliott,et al.  UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age , 2015, PLoS medicine.

[17]  Claire L. Lill,et al.  Increased acetyl and total histone levels in post-mortem Alzheimer's disease brain , 2015, Neurobiology of Disease.

[18]  Manolis Kellis,et al.  Alzheimery's disease pathology is associated with early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci , 2014, Nature Neuroscience.

[19]  Li Wang,et al.  Histone Acetyltransferase p300 Mediates Histone Acetylation of PS1 and BACE1 in a Cellular Model of Alzheimer's Disease , 2014, PloS one.

[20]  Bradley T. Hyman,et al.  The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease , 2014, Neuron.

[21]  Andre Fischer,et al.  Targeting histone-modifications in Alzheimer's disease. What is the evidence that this is a promising therapeutic avenue? , 2014, Neuropharmacology.

[22]  N. Perrimon,et al.  Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms. , 2014, Human molecular genetics.

[23]  Nick C Fox,et al.  Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease , 2013, Nature Genetics.

[24]  Huaxi Xu,et al.  Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy , 2013, Nature Reviews Neurology.

[25]  A. Singleton,et al.  TREM2 variants in Alzheimer's disease. , 2013, The New England journal of medicine.

[26]  A. Hofman,et al.  Variant of TREM2 associated with the risk of Alzheimer's disease. , 2013, The New England journal of medicine.

[27]  M. Rattray,et al.  Gene expression profiling in human neurodegenerative disease , 2012, Nature Reviews Neurology.

[28]  Urs Meyer,et al.  Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice , 2012, Journal of Neuroinflammation.

[29]  W. Kukull,et al.  Accuracy of the Clinical Diagnosis of Alzheimer Disease at National Institute on Aging Alzheimer Disease Centers, 2005–2010 , 2012, Journal of neuropathology and experimental neurology.

[30]  Michael A. Thomas,et al.  Integrating the Alzheimer's disease proteome and transcriptome: a comprehensive network model of a complex disease. , 2012, Omics : a journal of integrative biology.

[31]  G. D. Paolo,et al.  Linking lipids to Alzheimer's disease: cholesterol and beyond , 2011, Nature Reviews Neuroscience.

[32]  L. Fratiglioni,et al.  Role of genes and environments for explaining Alzheimer disease. , 2006, Archives of general psychiatry.

[33]  R. Tanzi,et al.  Twenty Years of the Alzheimer’s Disease Amyloid Hypothesis: A Genetic Perspective , 2005, Cell.

[34]  E. Gershon,et al.  Genetic studies in Alzheimer's disease , 2003, Dialogues in clinical neuroscience.

[35]  L. Peltonen,et al.  Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype. , 2002, American journal of human genetics.

[36]  B. Sommer Alzheimer's disease and the amyloid cascade hypothesis: ten years on. , 2002, Current opinion in pharmacology.

[37]  D. Selkoe Alzheimer's disease: genes, proteins, and therapy. , 2001, Physiological reviews.

[38]  K. Ashe,et al.  Ibuprofen Suppresses Plaque Pathology and Inflammation in a Mouse Model for Alzheimer's Disease , 2000, The Journal of Neuroscience.

[39]  B. Seltzer,et al.  A comparison of clinical features in early- and late-onset primary degenerative dementia. One entity or two? , 1983, Archives of neurology.

[40]  E. Lander,et al.  Characterization of single-nucleotide polymorphisms in coding regions of human genes , 1999 .