Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization
暂无分享,去创建一个
Frederik De Smet | Elisabetta Dejana | Sonja Loges | Bernard Gallez | Michael Simons | Peter Ratcliffe | Peter Carmeliet | A. Luttun | P. Carmeliet | F. Smet | M. Lampugnani | E. Dejana | K. Debackere | P. Ratcliffe | A. Pisacane | J. Aragonés | P. Maxwell | S. Loges | S. Vinckier | M. Mazzone | M. Simons | A. Lanahan | B. Gallez | Stefan Vinckier | P. Pollard | Patrick Maxwell | Bart Jonckx | B. Jordan | Massimiliano Mazzone | Aernout Luttun | T. Schmidt | Patrick J. Pollard | Ya-Min Tian | B. Jonckx | Daniela Dettori | Rodrigo Leite de Oliveira | Thomas Schmidt | Anthony A. Lanahan | Patrick Pollard | Carmen Ruiz de Almodovar | Julián Aragonés | Koen Debackere | Sabine Wyns | Benedicte Jordan | Alberto Pisacane | Maria Grazia Lampugnani | S. Wyns | D. Dettori | C. R. D. Almodóvar | Ya-min Tian | R. L. D. Oliveira | C. R. Almodóvar | Julián Aragonés | Daniela Dettori
[1] Patrick D. Sutphin,et al. Coordinate Regulation of the Oxygen-Dependent Degradation Domains of Hypoxia-Inducible Factor 1α , 2005, Molecular and Cellular Biology.
[2] Holger Gerhardt,et al. Pericytes: gatekeepers in tumour cell metastasis? , 2008, Journal of Molecular Medicine.
[3] A. Harris,et al. Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia. , 2003, Cancer research.
[4] Na Zhang,et al. Deletion of Vascular Endothelial Growth Factor in myeloid cells accelerates tumorigenesis , 2008, Nature.
[5] F. Orsenigo,et al. Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5 , 2008, Nature Cell Biology.
[6] Gavin Thurston,et al. The Delta paradox: DLL4 blockade leads to more tumour vessels but less tumour growth , 2007, Nature Reviews Cancer.
[7] A. Luttun,et al. Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1 , 2002, Nature Medicine.
[8] S. Egginton,et al. Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice , 2004, The Journal of physiology.
[9] R. Gerszten,et al. Role of endothelial nitric oxide synthase in endothelial activation: insights from eNOS knockout endothelial cells. , 2004, American journal of physiology. Cell physiology.
[10] Victoria L. Bautch,et al. The VEGF receptor Flt-1 spatially modulates Flk-1 signaling and blood vessel branching , 2008, The Journal of cell biology.
[11] Michael I. Wilson,et al. C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation , 2001, Cell.
[12] J. Peng,et al. The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[13] K. Alitalo,et al. VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia , 2003, The Journal of cell biology.
[14] D. McDonald,et al. Cellular abnormalities of blood vessels as targets in cancer. , 2005, Current opinion in genetics & development.
[15] M. Giacca,et al. Anti-PlGF Inhibits Growth of VEGF(R)-Inhibitor-Resistant Tumors without Affecting Healthy Vessels , 2007, Cell.
[16] P. Bedossa,et al. Overexpression of the Oxygen Sensors PHD-1, PHD-2, PHD-3, and FIH Is Associated with Tumor Aggressiveness in Pancreatic Endocrine Tumors , 2008, Clinical Cancer Research.
[17] Gabriele Bergers,et al. Modes of resistance to anti-angiogenic therapy , 2008, Nature Reviews Cancer.
[18] N. Asai,et al. Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin , 2008, Nature Cell Biology.
[19] R. Sainson,et al. Active involvement of Robo1 and Robo4 in filopodia formation and endothelial cell motility mediated via WASP and other actin nucleation‐promoting factors , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[20] K. Takeda,et al. Essential Role for Prolyl Hydroxylase Domain Protein 2 in Oxygen Homeostasis of the Adult Vascular System , 2007, Circulation.
[21] Soumen Paul,et al. Activation of the VEGFR1 Chromatin Domain , 2008, Journal of Biological Chemistry.
[22] K. Takeda,et al. Prolyl Hydroxylase Domain 2 Protein Suppresses Hypoxia-Induced Endothelial Cell Proliferation , 2007, Hypertension.
[23] W. Kaelin,et al. Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure. , 2008, Blood.
[24] Charles H. Graham,et al. Hypoxia-driven selection of the metastatic phenotype , 2007, Cancer and Metastasis Reviews.
[25] L. Naldini,et al. Targeting the tumor and its microenvironment by a dual-function decoy Met receptor. , 2004, Cancer cell.
[26] Jianhua Huang,et al. A Role for VEGF as a Negative Regulator of Pericyte Function and Vessel Maturation , 2008, Nature.
[27] W. Kaelin,et al. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. , 2008, Molecular cell.
[28] K. Takeda,et al. Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins. , 2008, Blood.
[29] P. Bénit,et al. Targeted Deletion of AIF Decreases Mitochondrial Oxidative Phosphorylation and Protects from Obesity and Diabetes , 2007, Cell.
[30] M. Corada,et al. Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, β-catenin, and the phosphatase DEP-1/CD148 , 2003, The Journal of cell biology.
[31] Lei Xu,et al. Perivascular nitric oxide gradients normalize tumor vasculature , 2008, Nature Medicine.
[32] Lei Xu,et al. Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases. , 2004, Cancer cell.
[33] M. Kiupel,et al. The Biphasic Role of the Hypoxia-Inducible Factor Prolyl-4-Hydroxylase, PHD2, in Modulating Tumor-Forming Potential , 2008, Molecular Cancer Research.
[34] Fabian Kiessling,et al. Vascular normalization in Rgs5-deficient tumours promotes immune destruction , 2008, Nature.
[35] V. Vasioukhin. Faculty Opinions recommendation of Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148. , 2003 .
[36] Joseph B. Kearney,et al. The VEGF receptor flt-1 (VEGFR-1) is a positive modulator of vascular sprout formation and branching morphogenesis. , 2004, Blood.
[37] P. Carmeliet,et al. Targeted Deficiency or Cytosolic Truncation of the VE-cadherin Gene in Mice Impairs VEGF-Mediated Endothelial Survival and Angiogenesis , 1999, Cell.
[38] M. Celeste Simon,et al. Multiple Factors Affecting Cellular Redox Status and Energy Metabolism Modulate Hypoxia-Inducible Factor Prolyl Hydroxylase Activity In Vivo and In Vitro , 2006, Molecular and Cellular Biology.
[39] Y. Fujii‐Kuriyama,et al. Hypoxia-inducible Transcription Factor-2α in Endothelial Cells Regulates Tumor Neovascularization through Activation of Ephrin A1* , 2008, Journal of Biological Chemistry.
[40] L. Claesson‐Welsh,et al. Platelet-derived growth factor receptor-beta promotes early endothelial cell differentiation. , 2006, Blood.
[41] C. Wykoff,et al. Genetic Analysis of the Role of the Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-inducible Factor (HIF) in Regulating HIF Transcriptional Target Genes* , 2004, Journal of Biological Chemistry.
[42] F. Soncin,et al. HIF-2α specifically activates the VE-cadherin promoter independently of hypoxia and in synergy with Ets-1 through two essential ETS-binding sites , 2007, Oncogene.
[43] D. Nolan,et al. Endothelial Progenitor Cells Control the Angiogenic Switch in Mouse Lung Metastasis , 2008, Science.
[44] R. Jain. Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy , 2005, Science.
[45] Robert A. Harris,et al. Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism , 2008, Nature Genetics.
[46] Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability. , 2008, Nature medicine.
[47] G. Semenza. Targeting HIF-1 for cancer therapy , 2003, Nature Reviews Cancer.
[48] Holger Gerhardt,et al. Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis , 2007, Nature.
[49] K. Miyazono,et al. Enhancement of angiogenesis through stabilization of hypoxia-inducible factor-1 by silencing prolyl hydroxylase domain-2 gene. , 2008, Molecular therapy : the journal of the American Society of Gene Therapy.
[50] Y. Fujii‐Kuriyama,et al. A Novel Class of Prolyl Hydroxylase Inhibitors Induces Angiogenesis and Exerts Organ Protection Against Ischemia , 2007, Arteriosclerosis, thrombosis, and vascular biology.
[51] P. Jaakkola,et al. Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases. , 2004, The Biochemical journal.