Rasa Bhasma is a multi-ingredient herbo-mineral or herbo-metallic formulation used in the treatment of rheumatoid arthritis. The quality of prepared Rasa Bhasma depends on the quality of raw material and standard manufacturing practice. Standardization techniques help in ensuring the safety and efficacy of the product. Hence the prepared Rasa Bhasma was subjected to both the traditional and modern standardization techniques. Result of the present study suggest that the prepared Rasa bhasma satisfied the required criteria of traditional standardization techniques and the modern standardization techniques confirmed the presence of metals such as Iron, Copper, Manganese, Zinc, Nickel, Cobalt, Arsenic, Cadmium, Lead and Mercury in the prescribed pharmacopeial limit. Infrared spectra analysis confirmed the absence of organic compounds. Hence the quality of the prepared Rasa Bhasma was established using traditional and modern standardization techniques.