Epidural Morphine by the Thoracic or Lumbar Routes in Cholecystectomy. Effect on Postoperative Pain and Respiratory Variables

Thirty-seven women undergoing elective cholecystectomy were randomised into two groups, receiving either lumbar epidural morphine (group L) or epidural morphine via the thoracic route (group T). The effect on pain relief was assessed by a visual analogue scale and included both resting pain and ‘provoked’ pain. Respiratory parameters (PEF, FEVI and FVC) were also studied. The patients were investigated preoperatively, and 4, 6, 12 and 24 hours after the start of surgery. No significant difference was observed between the groups concerning pain relief or respiratory performance. We conclude that after cholecystectomy lumbar epidural morphine is as effective as thoracic epidural morphine in relieving postoperative pain.

[1]  J. Plummer,et al.  The influence of drug polarity on the absorption of opioid drugs into CSF and subsequent cephalad migration following lumbar epidural administration: application to morphine and pethidine , 1987, Pain.

[2]  P. Hartvig,et al.  Pharmacokinetics of Epidural Morphine and Meperidine in Humans , 1987, Anesthesiology.

[3]  V. Larsen,et al.  Postoperative Pain Treatment after Upper Abdominal Surgery with Epidural Morphine at Thoracic or Lumbar Level , 1985, Acta anaesthesiologica Scandinavica.

[4]  D. R. Danielson,et al.  Comparison of lumbar and thoracic epidural morphine for relief of postthoracotomy pain. , 1985, Anesthesia and analgesia.

[5]  T. Hedner,et al.  Pharmacokinetic Aspects of Epidural Morphine Analgesia , 1983, Anesthesiology.

[6]  P. Bromage,et al.  Rostral Spread of Epidural Morphine , 1982, Anesthesiology.

[7]  M. Hirst,et al.  Regional analgesic effect of epidural morphine in volunteers , 1981, Canadian Anaesthetists' Society journal.

[8]  R. Knill,et al.  Lumbar epidural morphine as an effective analgesic following cholecystectomy , 1981, Canadian Anaesthetists' Society journal.

[9]  D. Welch,et al.  Forum , 1981 .

[10]  P. Bromage,et al.  Epidural narcotics in volunteers: Sensitivity to pain and to carbon dioxide , 1980, Pain.

[11]  E. C. Huskisson,et al.  Graphic representation of pain , 1976, Pain.

[12]  P. Bromage Spinal Epidural Analgesia , 1956 .

[13]  K. Inoue,et al.  Segmental effect of morphine injected into the epidural space in man. , 1981, Anesthesiology.