Impact of nonrigid motion correction technique on pixel‐wise pharmacokinetic analysis of free‐breathing pulmonary dynamic contrast‐enhanced MR imaging

To investigates the impact of nonrigid motion correction on pixel‐wise pharmacokinetic analysis of free‐breathing DCE‐MRI in patients with solitary pulmonary nodules (SPNs). Misalignment of focal lesions due to respiratory motion in free‐breathing dynamic contrast‐enhanced MRI (DCE‐MRI) precludes obtaining reliable time–intensity curves, which are crucial for pharmacokinetic analysis for tissue characterization.

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