Type 2 diabetes influences intraepithelial corneal nerve parameters and corneal stromal‐epithelial nerve penetration sites

The quantification of intraepithelial corneal basal nerve parameters by in vivo confocal microscopy represents a promising modality to identify the earliest manifestations of diabetic peripheral neuropathy. However, its diagnostic accuracy is hampered by its dependence on neuron length, with minimal consideration for other parameters, including the origin of these nerves, the corneal stromal‐epithelial nerve penetration sites. This study sought to utilize high‐resolution images of murine corneal nerves to analyze comprehensively the morphological changes associated with type 2 diabetes progression.

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