Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling.

[1]  Jose Russo,et al.  Human Breast Epithelial Cell Line, MCF-10 Isolation and Characterization of a Spontaneously Immortalized , 2006 .

[2]  E. Wolf,et al.  CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs , 1999, Cell.

[3]  M. Olivé,et al.  Long-term human breast carcinoma cell lines of metastatic origin: Preliminary characterization , 1978, In Vitro.

[4]  S. O’Brien,et al.  Establishment and characterization of three new continuous cell lines derived from human breast carcinomas. , 1978, Cancer research.

[5]  L. Griffith,et al.  Capturing complex 3D tissue physiology in vitro , 2006, Nature Reviews Molecular Cell Biology.

[6]  Pascale G. Charest,et al.  Big roles for small GTPases in the control of directed cell movement. , 2007, The Biochemical journal.

[7]  H. Kleinman,et al.  Matrigel: basement membrane matrix with biological activity. , 2005, Seminars in cancer biology.

[8]  Susan J. Ramus,et al.  Common origins of MDA-MB-435 cells from various sources with those shown to have melonoma properties , 2004, Clinical & Experimental Metastasis.

[9]  R K Jain,et al.  Direct measurement of interstitial convection and diffusion of albumin in normal and neoplastic tissues by fluorescence photobleaching. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[10]  S. Nathanson,et al.  Insights into the mechanisms of lymph node metastasis , 2003, Cancer.

[11]  Chad J. Creighton,et al.  MDA-MB-435 cells are derived from M14 Melanoma cells––a loss for breast cancer, but a boon for melanoma research , 2007, Breast Cancer Research and Treatment.

[12]  Melody A. Swartz,et al.  Dendritic-cell trafficking to lymph nodes through lymphatic vessels , 2005, Nature Reviews Immunology.

[13]  Steven A. Stacker,et al.  VEGF-D promotes the metastatic spread of tumor cells via the lymphatics , 2001, Nature Medicine.

[14]  P. Carmeliet.  Angiogenesis in health and disease , 2003, Nature Medicine.

[15]  M. Imamura,et al.  Association of CC chemokine receptor 7 with lymph node metastasis of esophageal squamous cell carcinoma. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

[16]  E. Galun,et al.  Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[17]  Z. Werb,et al.  HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1 , 2006, BMC Biochemistry.

[18]  H. Wiley,et al.  Expression of CC chemokine receptor-7 and regional lymph node metastasis of B16 murine melanoma. , 2001, Journal of the National Cancer Institute.

[19]  M. Neeman,et al.  Overexpression of vascular endothelial growth factor 165 drives peritumor interstitial convection and induces lymphatic drain: magnetic resonance imaging, confocal microscopy, and histological tracking of triple-labeled albumin. , 2002, Cancer research.

[20]  T. Mcclanahan,et al.  Involvement of chemokine receptors in breast cancer metastasis , 2001, Nature.

[21]  J. Grandis,et al.  Chemokine receptor 7 activates phosphoinositide-3 kinase-mediated invasive and prosurvival pathways in head and neck cancer cells independent of EGFR , 2005, Oncogene.

[22]  A. Harris,et al.  Absence of lymphangiogenesis and intratumoural lymph vessels in human metastatic breast cancer , 2003, The Journal of pathology.

[23]  R. Taichman,et al.  Expression of the chemokine receptor CCR7 in prostate cancer presenting with generalized lymphadenopathy: report of a case, review of the literature, and analysis of chemokine receptor expression. , 2005, Urologic oncology.

[24]  T. Yamano,et al.  CCL21 Chemokine Regulates Chemokine Receptor CCR7 Bearing Malignant Melanoma Cells , 2004, Clinical Cancer Research.

[25]  H. Klocker,et al.  The importance of the CXCL12-CXCR4 chemokine ligand-receptor interaction in prostate cancer metastasis. , 2004, Journal of experimental therapeutics & oncology.

[26]  D. Bates,et al.  Chemokine-mediated migration of melanoma cells towards lymphatics – a mechanism contributing to metastasis , 2007, Oncogene.

[27]  M. Skobe,et al.  Molecular characterization of lymphatic endothelial cells , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[28]  Thomas Hawighorst,et al.  Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis , 2001, Nature Medicine.

[29]  W. Klapper,et al.  Lymphatic spread of ductal pancreatic adenocarcinoma is independent of lymphangiogenesis , 2005, The Journal of pathology.

[30]  F. Tanaka,et al.  Expression of chemokine receptor CCR7 is associated with lymph node metastasis of gastric carcinoma. , 2002, Cancer research.

[31]  Rakesh K Jain,et al.  Molecular regulation of vessel maturation , 2003, Nature Medicine.

[32]  T. Mak,et al.  Polarization of Chemoattractant Receptor Signaling During Neutrophil Chemotaxis , 2022 .

[33]  M. Krangel,et al.  Chemokines have diverse abilities to form solid phase gradients. , 2001, Clinical immunology.

[34]  G. Hortobagyi,et al.  CCR7 and CXCR4 as Novel Biomarkers Predicting Axillary Lymph Node Metastasis in T1 Breast Cancer , 2005, Clinical Cancer Research.

[35]  D. Ruiter,et al.  Lack of lymphangiogenesis despite coexpression of VEGF-C and its receptor Flt-4 in uveal melanoma. , 2001, Investigative ophthalmology & visual science.

[36]  K. Alitalo,et al.  Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels. , 2005, Cancer research.

[37]  P. Iglesias,et al.  Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[38]  I. Macdonald,et al.  Metastasis: Dissemination and growth of cancer cells in metastatic sites , 2002, Nature Reviews Cancer.

[39]  L. Orci,et al.  Vascular endothelial growth factor‐C‐mediated lymphangiogenesis promotes tumour metastasis , 2001, The EMBO journal.

[40]  Melody A Swartz,et al.  Autologous morphogen gradients by subtle interstitial flow and matrix interactions. , 2006, Biophysical journal.

[41]  R. Hynes,et al.  Tumor-secreted vascular endothelial growth factor-C is necessary for prostate cancer lymphangiogenesis, but lymphangiogenesis is unnecessary for lymph node metastasis. , 2005, Cancer research.

[42]  Melody A. Swartz,et al.  Interstitial fluid flow induces myofibroblast differentiation and collagen alignment in vitro , 2005, Journal of Cell Science.

[43]  R. Jain.  Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy , 2005, Science.

[44]  T. Blankenstein,et al.  CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions. , 2004, Immunity.

[45]  K. Kaibuchi,et al.  Roles of Rho-family GTPases in cell polarisation and directional migration. , 2003, Current opinion in cell biology.

[46]  W. Hohenberger,et al.  Prediction of lymph node metastasis in colorectal carcinoma by expressionof chemokine receptor CCR7 , 2005, International journal of cancer.

[47]  I. Takanami.  Overexpression of CCR7 mRNA in nonsmall cell lung cancer: Correlation with lymph node metastasis , 2003, International journal of cancer.

[48]  James Briscoe,et al.  The interpretation of morphogen gradients , 2006, Development.

[49]  Zigmond Sh.  Ability of polymorphonuclear leukocytes to orient in gradients of chemotactic factors. , 1977 .

[50]  J. Cyster,et al.  A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[51]  S. Small,et al.  Morphogens: Precise Outputs from a Variable Gradient , 2006, Current Biology.

[52]  E. Butcher,et al.  Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues , 2005, Nature Immunology.

[53]  Federica Boschetti,et al.  Synergy between interstitial flow and VEGF directs capillary morphogenesis in vitro through a gradient amplification mechanism. , 2005, Proceedings of the National Academy of Sciences of the United States of America.