The biology of cell reproduction

PART I: BIOLOGY 1. The Cell Cycle Phases of the cell cycle Variability of the cell cycle 2. Nondividing Cells G0 cells Terminally differentiated cells 3. Populations of Cells Stem cells Transformed cells 4. Tissue Growth Growth in size Growth in number Doubling time Growth of tumors 5. Synchronization of Cells in the Cell Cycle Methods for synchronizing cells in culture Morphology of cells during the cell cycle PART II: CELL BIOLOGY 6. Temperature-Sensitive Mutants of the Cell Cycle Defining cell cycle mutants Conditional cell cycle mutants The execution point 7. Informational Content of Cells in Different Phases of the Cell Cycle Cell fusion Informational content of S phase cells Informational content of G0-G<small1 cells Premature chromosome condensation 8. Perturbation of the Cell Cycle by Drugs Actinomycin D Cycloheximide Other drugs Monoclonal antibodies 9. Growth in Size and Cell Proliferation Growth in size and cell DNA replication Growth in size and cell division The role of RNA polymerase II PART III: MOLECULAR BIOLOGY 10. The Environmental Signals Growth factors Inhibitory factors 11. Biochemical Events in the Cell Cycle Does the cell cycle exist? Controlling events and prerequisite events G1 and G0 S phase G2 and mitosis 12. Virally-Coded Proteins and Cell Proliferation SV4O and polyoma Adenovirus Other viruses Mechanisms of viral-induced cell DNA replication 13. Genetic Basis of Cell Proliferation Cdc genes in yeasts Retroviral oncogenes Cellular oncogenes Cdc genes in animal cells Some speculations References Index