The event-related optical signal (EROS) in visual cortex: replicability, consistency, localization, and resolution.

We previously reported a fast and localized noninvasive event-related optical signal (EROS) elicited by visual field quadrant stimulation in occipital brain areas (Gratton, Corballis, Cho, Fabiani, & Hood, 1995). We now present a replication and extension of that experiment. In addition, we propose a new method for estimating the cross-validity of the results based on intersubject correlations, report further data on the localization of EROS, and present an analysis of its spatial resolution. The results replicate our original findings. The intersubject correlation is generally quite high (r = .6-.8). The spatial resolution analysis indicates that activities from cortical areas located approximately 1.5 cm apart are measurable independently without cross talk. This study provides further support for the idea that noninvasive optical imaging can be used to derive images of brain activity combining good spatial and temporal resolution.

[1]  M Barinaga,et al.  New Imaging Methods Provide a Better View Into the Brain , 1997, Science.

[2]  D. Hood,et al.  Fast and Localized Event-Related Optical Signals (EROS) in the Human Occipital Cortex: Comparisons with the Visual Evoked Potential and fMRI , 1997, NeuroImage.

[3]  Enrico Gratton,et al.  Multifrequency cross‐correlation phase fluorometer using synchrotron radiation , 1984 .

[4]  G Gratton,et al.  Comparison of neuronal and hemodynamic measures of the brain response to visual stimulation: An optical imaging study , 2001, Human brain mapping.

[5]  Monica Fabiani,et al.  When in Doubt, Do it Both Ways: Brain Evidence of the Simultaneous Activation of Conflicting Motor Responses in a Spatial Stroop Task , 2001, Journal of Cognitive Neuroscience.

[6]  John S. George,et al.  In Vivo Observations of Rapid Scattered-Light Changes Associated with Electrical Events , 2002 .

[7]  D. Hood,et al.  Human optical signals and Visual Evoked Potentials (VEPS) from different cone systems , 1996 .

[8]  Monica Fabiani,et al.  Multiple visual memory phenomena in a memory search task. , 2003, Psychophysiology.

[9]  G. Gratton,et al.  Dynamic brain imaging: Event-related optical signal (EROS) measures of the time course and localization of cognitive-related activity , 1998 .

[10]  G. Gratton,et al.  Memory-driven processing in human medial occipital cortex: an event-related optical signal (EROS) study. , 1998, Psychophysiology.

[11]  David Friedman,et al.  Rapid Changes of Optical Parameters in the Human Brain During a Tapping Task , 1995, Journal of Cognitive Neuroscience.

[12]  G Gratton,et al.  Removing the heart from the brain: compensation for the pulse artifact in the photon migration signal. , 1995, Psychophysiology.

[13]  Risto Näätänen,et al.  RAPID COMMUNICATION Scalp-Recorded Optical Signals Make Sound Processing in the Auditory Cortex Visible? , 1999, NeuroImage.

[14]  Paul M. Corballis,et al.  Toward Noninvasive 3-D Imaging of the Time Course of Cortical Activity: Investigation of the Depth of the Event-Related Optical Signal , 2000, NeuroImage.

[15]  G. Curio,et al.  Somatosensory evoked fast optical intensity changes detected non-invasively in the adult human head , 2000, Neuroscience Letters.

[16]  A. Villringer,et al.  Non-invasive optical spectroscopy and imaging of human brain function , 1997, Trends in Neurosciences.

[17]  H. Spekreijse,et al.  Principal components analysis for source localization of VEPs in man , 1987, Vision Research.

[18]  D. Ts'o,et al.  Cortical functional architecture and local coupling between neuronal activity and the microcirculation revealed by in vivo high-resolution optical imaging of intrinsic signals. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[19]  D M Rector,et al.  Light scattering changes follow evoked potentials from hippocampal Schaeffer collateral stimulation. , 1997, Journal of neurophysiology.

[20]  G Gratton,et al.  Attention and probability effects in the human occipital cortex: an optical imaging study , 1997, Neuroreport.

[21]  G. Gratton,et al.  Shedding light on brain function: the event-related optical signal , 2001, Trends in Cognitive Sciences.

[22]  D. Hood,et al.  Shades of gray matter: noninvasive optical images of human brain responses during visual stimulation. , 1995, Psychophysiology.

[23]  L. Cohen.  Changes in neuron structure during action potential propagation and synaptic transmission. , 1973, Physiological reviews.

[24]  G. Gratton,et al.  Optimum filtering for EROS measurements. , 2003, Psychophysiology.

[25]  Martin Wolf,et al.  Detecting cerebral functional slow and fast signals by frequency-domain near-infrared spectroscopy using two different sensors , 2000 .