Software for constructing and verifying pedigrees within large genealogies and an application to the Old Order Amish of Lancaster County.

This paper describes PedHunter, a software package that facilitates creation and verification of pedigrees within large genealogies. A frequent problem in medical genetics is to connect distant relatives with a pedigree. PedHunter uses methods from graph theory to solve two versions of the pedigree connection problem for genealogies as well as other pedigree analysis problems. The pedigrees are produced by PedHunter as files in LINKAGE format ready for linkage analysis. PedHunter uses a relational database of genealogy data, with tables in specified format, for all calculations. The functionality and utility of PedHunter are illustrated by examples using the Amish Genealogy Database (AGDB), which was created for the Old Order Amish community of Lancaster County, Pennsylvania.

[1]  A A Schäffer,et al.  Genetic and physical mapping of the McKusick-Kaufman syndrome. , 1998, Human molecular genetics.

[2]  B. Weir.  Genetic Data Analysis II. , 1997 .

[3]  Rolf Apweiler,et al.  The SWISS-PROT protein sequence data bank and its supplement TrEMBL , 1997, Nucleic Acids Res..

[4]  Stanley Letovsky,et al.  The GDB Human Genome Database Anno 1997 , 1997, Nucleic Acids Res..

[5]  K K Kidd,et al.  PhenoDB: an integrated client/server database for linkage and population genetics. , 1996, Computers and biomedical research, an international journal.

[6]  M. Polymeropoulos,et al.  The gene for the Ellis-van Creveld syndrome is located on chromosome 4p16. , 1996, Genomics.

[7]  M. Daly,et al.  Rapid multipoint linkage analysis of recessive traits in nuclear families, including homozygosity mapping. , 1995, American journal of human genetics.

[8]  Jurg Ott,et al.  Handbook of Human Genetic Linkage , 1994 .

[9]  Dana S. Richards,et al.  Steiner tree problems , 1992, Networks.

[10]  D Curtis.  A program to draw pedigrees using LINKAGE or LINKSYS data files , 1990, Annals of human genetics.

[11]  C J Chapman.  A visual interface to computer programs for linkage analysis. , 1990, American journal of medical genetics.

[12]  A. Jelic,et al.  [The Ellis-van Creveld syndrome]. , 1989, Lijecnicki vjesnik.

[13]  Round Ap.  SCHESIS: computation in a multipoint linkage analysis program. , 1989 .

[14]  K. Lange,et al.  Programs for pedigree analysis: Mendel, Fisher, and dGene , 1988, Genetic epidemiology.

[15]  V A McKusick,et al.  Inbreeding and prereproductive mortality in the Old Order Amish. III. Direct and indirect effects of inbreeding. , 1987, American journal of epidemiology.

[16]  Kenneth Steiglitz,et al.  Combinatorial Optimization: Algorithms and Complexity , 1981 .

[17]  Shimon Even,et al.  Graph Algorithms , 1979 .

[18]  Mckusick Va.  The William Allan Memorial Award Lecture: Genetic nosology: three approaches. , 1978, American journal of human genetics.

[19]  Robert C. Elston,et al.  Extensions to Pedigree Analysis , 1975 .

[20]  C. J. Date.  An Introduction to Database Systems , 1975 .

[21]  V. McKusick,et al.  DWARFISM IN THE AMISH I. THE ELLIS-VAN CREVELD SYNDROME. , 1964, Bulletin of the Johns Hopkins Hospital.

[22]  V. McKusick,et al.  DWARFISM IN THE AMISH. , 1964, Transactions of the Association of American Physicians.

[23]  Edsger W. Dijkstra,et al.  A note on two problems in connexion with graphs , 1959, Numerische Mathematik.