OXA-181-producing Escherichia coli in China : the first 1 report and characterization using whole genome sequencing 2

19 We report the first OXA-181-producing strain in China. blaOXA-181 was found in 20 ST410 Escherichia coli strain WCHEC14828 from a Chinese patient without recent 21 travel history. Genome sequencing and conjugation experiment were performed. 22 blaOXA-181 was carried on a 51-kb self-transmissible IncX3 plasmid and was linked 23 with qnrS1 quinuolone-resistant gene. blaOXA-181 was introduced onto the IncX3 24 plasmid from a ColE2-type plasmid and IncX3 plasmids have the potential to mediate 25 the dissemination of blaOXA-181. 26 27

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